DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and gria2a

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	827	Identity:	279/827 - (33%)
Similarity:	436/827 - (52%)	Gaps:	65/827 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQ-LPTINL 136
            ::|..|||..:...|....:.:.|:||.....:.....|.|:...:.|:..  .|.|. |....|
Zfish    59 NLEVANSFAITNCFCSQFSRGVYAIFGFYDKKSVNTITSFCETLHVSFITP--SFPADGLNQFVL 121

  Fly   137 HPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELD-LN-GN- 198
            ...|...| .|..:|....||.|..:|:|...|.|::.:|.       |...|::::. :| ||
Zfish   122 QMRPDIKG-PLISLVEYYKWEKFAYLYDSDRGLSTLQAVLD-------TAAERKWQVTAINVGNL 178

  Fly   199 --------YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLE 255
                    ||::.:.:.|.::...::......:.:..:|...:|.....|.|||.|..:...||.
Zfish   179 KDEWKDEAYRSLFQDLENKNERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIANFGFVDGDLS 243

  Fly   256 PYQHAGTNITGLRLVSPDSEQVQEVA---KALYESEEPFQNVSCPLTNSMALVYDGVQLLAETYK 317
            ..|:.|.|::|.::|..|...|.:..   :||.|.|.|  .....:..:.||.||.||::.|.::
Zfish   244 KIQYGGANVSGFQIVDFDDPLVAKFDQRWEALEEKEYP--GADSRIRYTSALTYDAVQVMTEAFR 306

  Fly   318 HVNFRPVALS---------CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIE 373
            .::.:.:.:|         .|....|.:|..:...:|.:.::||||.|:||..|.|.::.:.|:|
Zfish   307 FLHKQRIDISRRGNNGDCLANPAVPWAQGVEIERALKQVRVDGLTGNIQFDQYGRRVNYTVNVME 371

  Fly   374 LAVSGMQKIGQWSGEDGFQENRPAPAHSLEP-DMRSLVNKSFVVITAISEPYGMLKETSEKLEGN 437
            |..||..|||.|:..|.....:    ..|.| |...:.||:.:|.|.:..||.|||:.:|....|
Zfish   372 LKNSGPVKIGYWNEMDKMAVTK----SDLFPNDTMGMENKTVIVTTILEAPYVMLKKNAELFTDN 432

  Fly   438 DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTS 502
            :::||:.::|..|::|..||.|..|:..|.|||..|.:|..||||:.|::..:||:.:..||:|.
Zfish   433 ERYEGYCVDLAAEIAKHCGFKYQLRIVADGKYGARDAETKIWNGMVGELVYGKADIAVAPLTITL 497

  Fly   503 ERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSP 567
            .||..:||:.|||||||.|:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:.:|::.|.||
Zfish   498 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSP 562

  Fly   568 AEWDNPYPCIEE-------PTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFT 625
            .||..     ||       |:|..|:|...|.||||:||.:|||.:::|::.|.|.|...|||||
Zfish   563 YEWHT-----EEFEDGQLGPSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT 622

  Fly   626 LILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEF 690
            ||::||||||||||||||.:|:||..|:||:| :..:.||....|:|..||:.|....:.:|:::
Zfish   623 LIIISSYTANLAAFLTVERMVSPIESAEDLAK-QTEIAYGTLDAGSTKEFFRRSKIALFDKMWQY 686

  Fly   691 MRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITERR-CTLTQVGALLDEKGYGIAMRK 751
            |:. .|........|||.||..|  .||:|:|||..|||.:|: |...:||..||.||||||..|
Zfish   687 MKSAEPSVFVKNTVEGVLRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPK 751

  Fly   752 NWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDS--GAVALEISNLGGVFLVMG 814
            ....|:.::.|||::.|||||.|:|.|||.:|   |.|.....:|  ...||.:||:.|||.::.
Zfish   752 GSALRNAVNLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGESKEKTSALSLSNVAGVFYILV 813

  Fly   815 VGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNT 861
            .|....:.|:|:|.....:..:...:::|...:..:.|  |..:|:|
Zfish   814 GGLGLAMLVALVEFCYKSRAEAKRMKMTFTDAMRSKAR--LSITGST 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	87/341 (26%)
		ANF_receptor	53..374	CDD:279440	78/324 (24%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	168/380 (44%)
		Lig_chan	543..816	CDD:278489	124/285 (44%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	87/343 (25%)
		ANF_receptor	51..373	CDD:279440	79/325 (24%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	169/382 (44%)
		Lig_chan	538..816	CDD:278489	124/286 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850