DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and Grin2d

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_036008580.1	Gene:	Grin2d / 14814	MGIID:	95823	Length:	1345	Species:	Mus musculus

Alignment Length:	766	Identity:	175/766 - (22%)
Similarity:	296/766 - (38%)	Gaps:	159/766 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 LGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVG 218
            :|||.              |..|.:...||..|        |....|:|..:||       ::..
Mouse   215 VGWEH--------------RGALTLDPGAGEAV--------LGAQLRSVSAQIR-------LLFC 250

  Fly   219 SMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQ----E 279
            :.......|:.|::.||....|       .|..:..:.....|:.:.|..|:.|....:.    .
Mouse   251 AREEAEPVFRAAEEAGLTGPGY-------VWFMVGPQLAGGGGSGVPGEPLLLPGGAPLPAGLFA 308

  Fly   280 VAKALYESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRP-VALSCNDDSAWDKGYTLVNY 343
            |..|.:..:     ::..:...:|:|..|.|.|...|   .|.| :...|...:...:|.:|..|
Mouse   309 VRSAGWRDD-----LARRVAAGVAVVARGAQALLRDY---GFLPELGHDCRAQNRTHRGESLHRY 365

  Fly   344 MKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVS-GMQKIGQWSGE------------------- 388
            ..::|.:  .....|:.:|...:..|.||.|... ..:.:|.|..:
Mouse   366 FMNITWD--NRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPV 428

  Fly   389 DGFQ-------ENRP----APAHSL-------EPDMRSLVNKSFVVITAISEPYGMLKETSEKLE 435
            |..|       |.||    .||..:       ....||.:|::..::...|.|....:......
Mouse   429 DDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSLVAPRSPPPDAPRPEKRCC- 492

  Fly   436 GNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYG-GIDPKTGEWNGMLREIIDSRADMGITDLT 499
                 :||.|:::..|:..:||||...|..:.|:| .||   |.||||:.|:...||||.|..||
Mouse   493 -----KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID---GVWNGMIGEVFYQRADMAIGSLT 549

  Fly   500 MTSERESGVDFTIPFMSLGIGILFRKP--MKEPPKLFSF------MS--PFSGEVWLWLGLAYMG 554
            :..||...|||::||:..||.::..:.  ...|....:|      ||  |:|..||:.:.:..:.
Mouse   550 INEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWLMPPMSPEPYSPAVWVMMFVMCLT 614

  Fly   555 -VSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELA--PKAYSTRA 616
             |::::|:...|||..::......:.|.  .:.|:....:|. :.||:...|...  |:..:::.
Mouse   615 VVAVTVFIFEYLSPVGYNRSLATGKRPG--GSTFTIGKSIWL-LWALVFNNSVPVENPRGTTSKI 676

  Fly   617 VAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNY-----GAKIGGATFNFF 676
            :...|.||.:|.::|||||||||:..|..|..::...|....:....|     |....|:|....
Mouse   677 MVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNI 741

  Fly   677 KESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSNY--------AFLMESTTIEYIT--ERRC 731
            : ||||          |...||...||   .|||.:..        ||:.::..:.|:.  :..|
Mouse   742 R-SNYP----------DMHSYMVRYNQ---PRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGC 792

  Fly   732 TLTQVGA--LLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADE 794
            .|..:|:  :....|||||:.|...::..:..|:|:......:..::..|.     .|.|.:...
Mouse   793 KLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL-----SGICHNDKI 852

  Fly   795 DSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMV--------LGVKERSD 837
            :..:..|:|.|:.|||.::.|.....:.|...|.:        ||...|.|
Mouse   853 EVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMD 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	47/261 (18%)
		ANF_receptor	53..374	CDD:279440	43/224 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	105/400 (26%)
		Lig_chan	543..816	CDD:278489	69/292 (24%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:415822	46/245 (19%)
Grin2d	XP_036008580.1	PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	115/447 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840