DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Grin2c

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_017169765.1	Gene:	Grin2c / 14813	MGIID:	95822	Length:	1307	Species:	Mus musculus

Alignment Length:	1010	Identity:	226/1010 - (22%)
Similarity:	389/1010 - (38%)	Gaps:	229/1010 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILTSLLLAFPGC---RGER-TNVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGN 78
            :|||||.|:.|.   :||: ..|.:|:.::.| |:......::..|..:..|::..:::.:...|
Mouse    72 LLTSLLGAWAGLGAGQGEQAVTVAVVFGSSGP-LQAQARTRLTPQNFLDLPLEIQPLTIGVNNTN 135

  Fly    79 SFETSKKLCKMLRQNLVAVFGPTSNLAAR-HAMSICD-------AKELPFLDTRWDFGAQLPTIN 135
            ......::|.:|.             ||| |.:...|       |:.|.|:.::    ..:|.::
Mouse   136 PSSILTQICGLLG-------------AARVHGIVFEDNVDTEAVAQLLDFVSSQ----THVPILS 183

  Fly   136 LHPHPAT-------------LGVALRDMVVAL-------GWESFTII--YESGE--YLPTVRELL 176
            :....|.             |||:|...:..|       .|.:|.:|  ...|.  :|..||.:.
Mouse   184 ISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVA 248

  Fly   177 QMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYR 241
            .....:...:.|...||...|......|.:|..|....|...|.......|.:|.|.|||...:.
Mouse   249 DASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHV 313

  Fly   242 YIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLTNSMALVY 306
            :::.||...:.|..|....    .||..|..:|.::....|                      |.
Mouse   314 WLVPNLALGSTDAPPAAFP----VGLISVVTESWRLSLRQK----------------------VR 352

  Fly   307 DGVQLLA--------------------------------ETYKHVNFRPVALSCNDDSAWDKGYT 339
            |||.:||                                ..|:|:  ..|.....|.|....||.
Mouse   353 DGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRHL--LNVTWEGRDFSFSPGGYL 415

  Fly   340 LVNYMKSLTLN-----GLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPA 399
            :...|..:.||     .:.|  |:|:..|               ..|...|          |..:
Mouse   416 VQPTMVVIALNRHRLWEMVG--RWDHGVL---------------YMKYPVW----------PRYS 453

  Fly   400 HSLEP--DMR-----SLVNKSFVVITAISEP--YGMLKETSE-KLEGNDQF-------------E 441
            .||:|  |.|     :|..:.||::.: .:|  .|.:..|.. :.:.|..|             :
Mouse   454 TSLQPVVDSRHLTVATLEERPFVIVES-PDPGTGGCVPNTVPCRRQSNHTFSSGDITPYTKLCCK 517

  Fly   442 GFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERES 506
            ||.|:::.:|:|.:.|||...|..:.|:|  ....|.||||:.|:...||||.|..||:..||..
Mouse   518 GFCIDILKKLAKVVKFSYDLYLVTNGKHG--KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSE 580

  Fly   507 GVDFTIPFMSLGIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMG-VSISMFVLGRLSPAE 569
            .:||::||:..||.::. |......|.  :|:.|:|..||:.:.:..:. |:|::|:....||..
Mouse   581 IIDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVS 643

  Fly   570 WDNPYPCIEEPTELEN----QFSFANCLWFSIGALLQQGSELA--PKAYSTRAVAASWWFFTLIL 628
            ::      :..|:.:.    .|:....:|. :.||:...|...  |:..:::.:...|.||.:|.
Mouse   644 YN------QNLTKGKKSGGPSFTIGKSVWL-LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIF 701

  Fly   629 VSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRD 693
            ::|||||||||:..|..:..::...|....:....|      ..|.|....|..|.:.:....||
Mouse   702 LASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQY------PPFRFGTVPNGSTERNIRSNYRD 760

  Fly   694 NPQYMTNTNQEGVD-----------RVENSNYAFLMESTTIEYIT--ERRCTLTQVGA--LLDEK 743
            ...:|...||..|:           .|.....||:.::..:.|:.  :..|.|..:|:  :....
Mouse   761 MHTHMVKFNQRSVEDALTSLKMGARHVSRKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATT 825

  Fly   744 GYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGG 808
            ||||||:|:..::..:..|:|:....|...|::|.|.     .|.|.:...:..:..|:|.|:.|
Mouse   826 GYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL-----SGICHNEKNEVMSSKLDIDNMAG 885

  Fly   809 VFLVMGVGSFFGIFVSLLEMVLGVKER---SDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNS 870
            ||.::.|.....:.|...|.::..|.|   ...:|:.|   ||...|.|..|....:::..|
Mouse   886 VFYMLLVAMGLALLVFAWEHLVYWKLRHSVPSSSQLDF---LLAFSRGIYSCFNGVQSLPSP--- 944

  Fly   871 SRSNASSKSKGSSMS-----VDSLPEDTSEADASG 900
            :|..:...:.||:.:     :.:..:..|.||.||
Mouse   945 ARPPSPDLTAGSAQANVLKMLQAARDMVSTADVSG 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	76/422 (18%)
		ANF_receptor	53..374	CDD:279440	71/389 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	104/408 (25%)
		Lig_chan	543..816	CDD:278489	68/294 (23%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	75/418 (18%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	108/428 (25%)
		NMDAR2_C	905..>980	CDD:371139	18/81 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840