DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Grin2b

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001350679.1	Gene:	Grin2b / 14812	MGIID:	95821	Length:	1482	Species:	Mus musculus

Alignment Length:	1044	Identity:	218/1044 - (20%)
Similarity:	402/1044 - (38%)	Gaps:	245/1044 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 STEASFPLGFILTSLLLAFPG--CRGERT----NVGLVYENTDPDLEKIFHLAISKANEENEDLQ 66
            |.|...| .|.|...:||..|  .|.:::    .:.::...|..:      :||..|:|:::
Mouse     4 SAECCSP-KFWLVLAVLAVSGSKARSQKSAPSIGIAVILVGTSDE------VAIKDAHEKDD--- 58

  Fly    67 LHGVSV--SIEPGNSFETSKK-----LCKMLRQNLV--AVFGPTSNLAARHAMSICDAKELPFLD 122
            .|.:||  .:|.....||..|     :|.::....:  .||...::..|       .|:.|.|:.
Mouse    59 FHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEA-------IAQILDFIS 116

  Fly   123 TRWDFGAQLPTINLH--------------------PHPATLGVALRDMVVALGWESFTII--YES 165
            .:    ...|.:.:|                    |........:.:::....|..|:|:  |..
Mouse   117 AQ----TLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFP 177

  Fly   166 G--EYLPTVRELLQMYGTAGPTVTVRRYELDL---NGNYRNVLRRIRNADDFSFVVVGSMATLPE 225
            |  :::..:|..::..........|...::.|   :...:|.|:::::.      ::....|..|
Mouse   178 GYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSP------IILLYCTKEE 236

  Fly   226 ---FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYES 287
               .|:.|..|||....|.:|:.:|.....|..|.:..    |||..||.|.
Mouse   237 ATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFP----TGLISVSYDE------------- 284

  Fly   288 EEPFQNVSCPLTNSMALVYDGVQLL----AETYKHVNFRPVALSCNDDSAWDKGY---TLVNYMK 345
                .:...|     |.|.||:.::    ::.....:|.|...|...::...:.|   .|..|:.
Mouse   285 ----WDYGLP-----ARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLI 340

  Fly   346 SLTLNGLTGPIRFDYEGLRTDFKLEVIEL-AVSGMQKIGQWSGEDGFQEN-----RPAP-AHSLE 403
            ::|..|..  :.|..:|.:...||.:|.| .....:::|:|. :...|..     |..| ....|
Mouse   341 NVTFEGRN--LSFSEDGYQMHPKLVIILLNKERKWERVGKWK-DKSLQMKYYVWPRMCPETEEQE 402

  Fly   404 PDMRSLV---NKSFVVITAI-------------------------SEPYGMLKETSEKLEGNDQF 440
            .|..|:|   ...||::.::                         .|| |.:|:..
Mouse   403 DDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEP-GYIKKCC--------- 457

  Fly   441 EGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERE 505
            :||.|:::.::||.:.|:|...|..:.|:|  ....|.||||:.|::..||.|.:..||:..||.
Mouse   458 KGFCIDILKKISKSVKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTINEERS 520

  Fly   506 SGVDFTIPFMSLGIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVS-ISMFVLGRLSPA 568
            ..|||::||:..||.::. |......|.  :|:.|||.:||:.:.:..:.|| :::||....||.
Mouse   521 EVVDFSVPFIETGISVMVSRSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPV 583

  Fly   569 EWDNPYPCIEEPTELEN-QFSFANCLWFSIGALLQQGSELA-PKAYSTRAVAASWWFFTLILVSS 631
            .::.   |:.:..|... .|:....:|...|.:......:. ||..:::.:.:.|.||.:|.::|
Mouse   584 GYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLAS 645

  Fly   632 YTANLAAFLTVESLVTPINDADDLSKNKGG-----VNYGAKIGGATFNFFKESNYPTYQRMYEFM 691
            ||||||||:..|..|..::...|....:..     ..:|....|:|....:.:    |..|:
Mouse   646 YTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMH--- 703

  Fly   692 RDNPQYMTNTNQEGVD---------RVENSNYAFLMESTTIEYITER--RCTLTQVGA--LLDEK 743
                .||...||.|||         :::    ||:.::..:.|:..|  .|.|..:|:  :....
Mouse   704 ----AYMGKFNQRGVDDALLSLKTGKLD----AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFAST 760

  Fly   744 GYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGG 808
            |||||::|:..::..:..|:|::...|.:.:::..|..     |.|.:...:..:..|:|.|:.|
Mouse   761 GYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT-----GICHNEKNEVMSSQLDIDNMAG 820

  Fly   809 VFLVMGV-------------------------------GSFFGIFVSLLEMVLGVKERSDENQVS 842
            ||.::|.                               |..|.|...:...:.||.....::.::
Mouse   821 VFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMN 885

  Fly   843 FKTELLDE-----IRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMSVDSLPEDTSEADASGKH 902
            ..|..::.     :|.:       :..|...|.|..|.|.:|....:..:|...|.||...|..|
Mouse   886 SPTATMNNTHSNILRLL-------RTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTH 943

  Fly   903 NHGK 906
            :..|
Mouse   944 SDCK 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	71/400 (18%)
		ANF_receptor	53..374	CDD:279440	67/366 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	102/416 (25%)
		Lig_chan	543..816	CDD:278489	69/324 (21%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	72/409 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	107/436 (25%)
		NMDAR2_C	840..1482	CDD:402274	20/115 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846371
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840