Protein Alignment Grik and Grin2a

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 840
• Identity: 188/840 - (22%)
• Similarity: 335/840 - (39%)
• Gaps: 199/840 - (23%)

  Fly   199 YRNVLRRIRNADDFSFV--VVGSMATLPEFFK------------------------------QAQ 231
            ||:.:..|:...|.|||  .:.::.||...|:                              :|:
Mouse   180 YRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEAR 244

  Fly   232 QVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSC 296
            .:||...|:.:|:.:|.....:|.|.:..    :||..||.|...        |..|
Mouse   245 SLGLTGYDFFWIVPSLVSGNTELIPKEFP----SGLISVSYDDWD--------YSLE-------- 289

  Fly   297 PLTNSMALVYDGVQLLA-------ETYKHVNFRPVA-LSCNDDSAWDKG--YTLVNYMKSLTLNG 351
                  |.|.||:.:|.       |.:.::   |.| .||...:...:.  :||..:|.::|.:|
Mouse   290 ------ARVRDGLGILTTAASSMLEKFSYI---PEAKASCYGQTEKPETPLHTLHQFMVNVTWDG 345

  Fly   352 LTGPIRFDYEGLRTDFKLEVIELAVS-GMQKIGQWSGEDGFQENRPAPAH----SLEPDMRSLVN 411
              ..:.|..||.:...:|.||.|... ..:|:|:|..:.....:...|.:    ..|||     :
Mouse   346 --KDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPD-----D 403

  Fly   412 KSFVVITAISEPYGMLKE------------------------TSEKLEGNDQFEGFGIELIDELS 452
            ....::|....|:.::::                        |:|.:......:||.|:::.:||
Mouse   404 NHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLS 468

  Fly   453 KKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSL 517
            :.:.|:|...|..:.|:|  ......||||:.|::..||.|.:..||:..||...|||::||:..
Mouse   469 RTVKFTYDLYLVTNGKHG--KKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVET 531

  Fly   518 GIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVS-ISMFVLGRLSPAEWDNPYPCIEEP 580
            ||.::. |......|.  :|:.|||..||:.:.:..:.|| |::||....||..::......:.|
Mouse   532 GISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAP 594

  Fly   581 TELENQFSFANCLWFSIGALLQQGSELA-PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVES 644
            .  ...|:....:|...|.:......:. ||..:::.:.:.|.||.:|.::|||||||||:..|.
Mouse   595 H--GPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE 657

  Fly   645 LVTPINDADDLSKNK-----GGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQE 704
            .|..:....|....:     ....:|....|:|....: :|||       :|.   ||||..||.
Mouse   658 FVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR-NNYP-------YMH---QYMTKFNQR 711

  Fly   705 GVD---------RVENSNYAFLMESTTIEYITER--RCTLTQVGA--LLDEKGYGIAMRKNWPYR 756
            ||:         :::    ||:.::..:.|...|  .|.|..:|:  :....|||||::|..|::
Mouse   712 GVEDALVSLKTGKLD----AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWK 772

  Fly   757 DTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVM-------- 813
            ..:..|:|:....|.:.:::|.|..     |.|.:...:..:..|:|.|:.|||.::
Mouse   773 RQIDLALLQFVGDGEMEELETLWLT-----GICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSL 832

  Fly   814 ------------------GV-----GSFFGIFVSLLEMVLGV-----KERSDENQVSFKTELLDE 850
                              ||     |..|.|...:...:.||     |:..|.|....::.:|..
Mouse   833 ITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKL 897

  Fly   851 IRFILQCSGNTKAVKYPKNSSRSNASSKS----KGSSMSVDSLPEDTSEADASGKHNHGK 906
            :|.....|..:.     .||||.::..::    :..|:.||.:.:..:...:..:...||
Mouse   898 LRSAKNISNMSN-----MNSSRMDSPKRAADFIQRGSLIVDMVSDKGNLIYSDNRSFQGK 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	50/238 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	104/414 (25%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	50/237 (21%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	106/424 (25%)
		NMDAR2_C	839..1464	CDD:463148	22/119 (18%)