DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Grin2a

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_032196.2	Gene:	Grin2a / 14811	MGIID:	95820	Length:	1464	Species:	Mus musculus

Alignment Length:	840	Identity:	188/840 - (22%)
Similarity:	335/840 - (39%)	Gaps:	199/840 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 YRNVLRRIRNADDFSFV--VVGSMATLPEFFK------------------------------QAQ 231
            ||:.:..|:...|.|||  .:.::.||...|:                              :|:
Mouse   180 YRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEAR 244

  Fly   232 QVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSC 296
            .:||...|:.:|:.:|.....:|.|.:..    :||..||.|...        |..|
Mouse   245 SLGLTGYDFFWIVPSLVSGNTELIPKEFP----SGLISVSYDDWD--------YSLE-------- 289

  Fly   297 PLTNSMALVYDGVQLLA-------ETYKHVNFRPVA-LSCNDDSAWDKG--YTLVNYMKSLTLNG 351
                  |.|.||:.:|.       |.:.::   |.| .||...:...:.  :||..:|.::|.:|
Mouse   290 ------ARVRDGLGILTTAASSMLEKFSYI---PEAKASCYGQTEKPETPLHTLHQFMVNVTWDG 345

  Fly   352 LTGPIRFDYEGLRTDFKLEVIELAVS-GMQKIGQWSGEDGFQENRPAPAH----SLEPDMRSLVN 411
              ..:.|..||.:...:|.||.|... ..:|:|:|..:.....:...|.:    ..|||     :
Mouse   346 --KDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPD-----D 403

  Fly   412 KSFVVITAISEPYGMLKE------------------------TSEKLEGNDQFEGFGIELIDELS 452
            ....::|....|:.::::                        |:|.:......:||.|:::.:||
Mouse   404 NHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLS 468

  Fly   453 KKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSL 517
            :.:.|:|...|..:.|:|  ......||||:.|::..||.|.:..||:..||...|||::||:..
Mouse   469 RTVKFTYDLYLVTNGKHG--KKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVET 531

  Fly   518 GIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVS-ISMFVLGRLSPAEWDNPYPCIEEP 580
            ||.::. |......|.  :|:.|||..||:.:.:..:.|| |::||....||..::......:.|
Mouse   532 GISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAP 594

  Fly   581 TELENQFSFANCLWFSIGALLQQGSELA-PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVES 644
            .  ...|:....:|...|.:......:. ||..:::.:.:.|.||.:|.::|||||||||:..|.
Mouse   595 H--GPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE 657

  Fly   645 LVTPINDADDLSKNK-----GGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQE 704
            .|..:....|....:     ....:|....|:|....: :|||       :|.   ||||..||.
Mouse   658 FVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR-NNYP-------YMH---QYMTKFNQR 711

  Fly   705 GVD---------RVENSNYAFLMESTTIEYITER--RCTLTQVGA--LLDEKGYGIAMRKNWPYR 756
            ||:         :::    ||:.::..:.|...|  .|.|..:|:  :....|||||::|..|::
Mouse   712 GVEDALVSLKTGKLD----AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWK 772

  Fly   757 DTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVM-------- 813
            ..:..|:|:....|.:.:::|.|..     |.|.:...:..:..|:|.|:.|||.::
Mouse   773 RQIDLALLQFVGDGEMEELETLWLT-----GICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSL 832

  Fly   814 ------------------GV-----GSFFGIFVSLLEMVLGV-----KERSDENQVSFKTELLDE 850
                              ||     |..|.|...:...:.||     |:..|.|....::.:|..
Mouse   833 ITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKL 897

  Fly   851 IRFILQCSGNTKAVKYPKNSSRSNASSKS----KGSSMSVDSLPEDTSEADASGKHNHGK 906
            :|.....|..:.     .||||.::..::    :..|:.||.:.:..:...:..:...||
Mouse   898 LRSAKNISNMSN-----MNSSRMDSPKRAADFIQRGSLIVDMVSDKGNLIYSDNRSFQGK 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	50/234 (21%)
		ANF_receptor	53..374	CDD:279440	46/216 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	104/414 (25%)
		Lig_chan	543..816	CDD:278489	75/323 (23%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	50/242 (21%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	106/424 (25%)
		HisJ	<458..>541	CDD:223904	30/84 (36%)
		Lig_chan	556..828	CDD:278489	73/293 (25%)
		NMDAR2_C	839..1464	CDD:287527	22/119 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840