DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Grid2

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	892	Identity:	243/892 - (27%)
Similarity:	430/892 - (48%)	Gaps:	126/892 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVS---IEPGNSFETSKKLCKMLRQNLVA 96
            ::|.:::.:....:::|..|:...|:..|.||...::.|   ::..|.|:..::.|:::.|.::|
Mouse    28 HIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILA 92

  Fly    97 VFGPTSNLAARHAMSICDAKELPFL-------------------DTRWDFGAQLPTINLHPHPAT 142
            :.......:|....|:.||..:|.|                   :...|:     |:::.| |..
Mouse    93 LVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDY-----TLSVRP-PVY 151

  Fly   143 LGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLN----------- 196
            |...:..:|....|:.|.|.|:|...:..::|.|......|..|.:::.|.::|
Mouse   152 LNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMR 216

  Fly   197 ----GNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDL-EP 256
                ..||:.|||.        ::|.:.||...|..:..:..||..|..:||.|.:.:.:|: |.
Mouse   217 IEELNRYRDTLRRA--------ILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQEL 273

  Fly   257 YQHAGTNITGLRLVSPDSEQVQE--------VAKALYESEEPF-QNVSCPLTNSMALVYDGVQLL 312
            .:.:...:|.:|...|..:.:.:        ::.:|.:.::|| ||:..    |...:||.|.||
Mouse   274 VRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFAQNMEI----SNLYIYDTVLLL 334

  Fly   313 AETY-KHVNFRP----VALSC--NDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLE 370
            |..: |.:..|.    .:|||  .:...|..|.:::..:|...:|||||.:.|...|...:...|
Mouse   335 ANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFE 399

  Fly   371 VI------ELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKE 429
            ::      ||. .|::|:|.|:...|.  |.......||.:||.:|.:   |:|.:.||:.|:
Mouse   400 ILGTNYGEELG-RGVRKLGCWNPVTGL--NGSLTDKKLENNMRGVVLR---VVTVLEEPFVMV-- 456

  Fly   430 TSEKLEGN-DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADM 493
             ||.:.|. .:::||.|:::|.||..|||:|...:..|:|||. ..:.|.|||::.|::..|||:
Mouse   457 -SENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGS-PQEDGTWNGLVGELVFKRADI 519

  Fly   494 GITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSIS 558
            ||:.||:|.:||:.||||..:|...:|:|.|:..| ...:|:.::||...:|..:....:.|.:.
Mouse   520 GISALTITPDRENVVDFTTRYMDYSVGVLLRRAEK-TVDMFACLAPFDLSLWACIAGTVLLVGLL 583

  Fly   559 MFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWF 623
            :::|      .|.|| |.::..:....  :..|.:||..|:.:|||.|:.....:||.:..:||.
Mouse   584 VYLL------NWLNP-PRLQMGSMTST--TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWL 639

  Fly   624 FTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQR-- 686
            |.||::||||||||||||:..:.:.|....|||| :..:.||..:..|.:...:......::|
Mouse   640 FALIVISSYTANLAAFLTITRIESSIQSLQDLSK-QTDIPYGTVLDSAVYQHVRMKGLNPFERDS 703

  Fly   687 MYEFM-----RDN-PQYMTNTNQEGVDRVENSNYAFLMESTTIEY--ITERRCTLTQVGALLDEK 743
            ||..|     |.| .:.....:|.|:.:|:..||||:.::..:||  |.:..|:...||..:.::
Mouse   704 MYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADR 768

  Fly   744 GYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACS-----DADEDSGAVALEI 803
            |||||::...||||..||.:||:|:.|.:..:|.|||.:   .|.|.     ||.:..|  ||:|
Mouse   769 GYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPK---NGQCDLYSSVDAKQKGG--ALDI 828

  Fly   804 SNLGGVFLVMGVGSFFGIFVSLLEMVLG------VKERSDENQVSFK 844
            .:|.|||.::..|......:::||....      |..:.|:.::..:
Mouse   829 KSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKEDDKEIDLE 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	90/413 (22%)
		ANF_receptor	53..374	CDD:279440	82/380 (22%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	128/380 (34%)
		Lig_chan	543..816	CDD:278489	92/287 (32%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		69/334 (21%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	92/421 (22%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	129/383 (34%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840