DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Grid1

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	866	Identity:	235/866 - (27%)
Similarity:	408/866 - (47%)	Gaps:	109/866 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVS---IEPGNSFETSKKLCKMLRQNLVA 96
            ::|.::|......:::|.||:|..:..::.||...::.|   ||..|.|:..::.|.::.|.::|
Mouse    25 HIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILA 89

  Fly    97 VFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLG----------VALRD-- 149
            :...|...:|....|:.||..:|.|..:.:.|.. |....|.:|:..|          |.|.|
Mouse    90 LVTSTGCASANALQSLTDAMHIPHLFVQRNPGGS-PRTACHLNPSPDGEAYTLASRPPVRLNDVM 153

  Fly   150 --MVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLN---------------G 197
              :|..|.|:.|.:.|:|...:..::..|......|..|::::.:.:::               .
Mouse   154 LRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELN 218

  Fly   198 NYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGT 262
            .||:.|||.        :::.|......|..:|.:..|.:.|..::..|.:....::....|:..
Mouse   219 RYRDTLRRA--------ILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSAL 275

  Fly   263 -NITGLRLVSPDSEQVQE-------VAKALYESEEPFQNVSCPLTNSMALVYDGVQLLAETY-KH 318
             .:|.:|.:.|.::..|:       ::..|.:.:|.:..:   |..|...:||.|.:||..: :.
Mouse   276 GRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQM---LQISNLYLYDSVLMLANAFHRK 337

  Fly   319 VNFRP----VALSC--NDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVS 377
            :..|.    .:|:|  .....|:.|.::::.:|...:.||||.:.|..:......:.|::....|
Mouse   338 LEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYS 402

  Fly   378 -----GMQKIGQWSGEDGFQ---ENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKL 434
                 .|:|:..|..|.|..   :.||..:.     ::.|..|   |:|.:.||:.|:   :|.:
Mouse   403 ETFGKDMRKLATWDSEKGLNGSLQERPMGSR-----LQGLTLK---VVTVLEEPFVMV---AENI 456

  Fly   435 EGN-DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDL 498
            .|. .:::||.|:::|.|:|.|||.|......|.:||.....| .||||:.|:|..|||:.|:.:
Mouse   457 LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNT-SWNGMIGELISKRADLAISAI 520

  Fly   499 TMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLG 563
            |:|.||||.|||:..:|...:|||.:|| :|...:||..:||...||..:..|...|.:.:|||.
Mouse   521 TITPERESVVDFSKRYMDYSVGILIKKP-EEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLN 584

  Fly   564 RLSPAEWDN---PYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFT 625
            |:......:   |.|....        :..:.:|...||.:|||.|.:..:.:.|.|..|||.||
Mouse   585 RIQAVRSQSATQPRPSASA--------TLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGSWWLFT 641

  Fly   626 LILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFK-ESNYP-----TY 684
            ||:.|||||||||||||..:..||....||||.. .::||.....|.:.:|: :...|     |:
Mouse   642 LIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQL-EMSYGTVRDSAVYEYFRAKGTNPLEQDSTF 705

  Fly   685 QRMYEFMRDN--PQYMTNTNQEGVDRVENSNYAFLMESTTIEY--ITERRCTLTQVGALLDEKGY 745
            ..::..:..|  .....:...||:.:.:..|||||.:...:||  :|:..|::|.:|..:..|||
Mouse   706 AELWRTISKNGGADNCVSNPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGY 770

  Fly   746 GIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGAC---SDADEDSGAVALEISNLG 807
            |||::...||||..||.:||:|:.|.|..:|.|||...   |.|   |.:...:...:|::.:..
Mouse   771 GIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHT---GRCDLTSHSSTQTEGKSLKLHSFA 832

  Fly   808 GVFLVMGVGSFFGIFVSLLEM 828
            |||.::.:|......|:.||:
Mouse   833 GVFCILAIGLLLACLVAALEL 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	82/405 (20%)
		ANF_receptor	53..374	CDD:279440	74/367 (20%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	137/383 (36%)
		Lig_chan	543..816	CDD:278489	93/288 (32%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		85/427 (20%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	83/409 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	138/386 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840