DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Gria4

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	926	Identity:	305/926 - (32%)
Similarity:	468/926 - (50%)	Gaps:	91/926 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILTSLLLAFPGCRGERTNV--------GLVYENTDPDLEKIFHLAI------SKANEENEDLQLH 68
            |...::|.|.|..|.....        ||...|||.:. ..|.|||      ..|:|...:|..|
Mouse     4 ICRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEY-TAFRLAIFLHNTSPNASEAPFNLVPH 67

  Fly    69 GVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKEL----PFLDTRWDFGA 129
              ..:||..|||..:...|....:.:.|:||.....:.....|.|.|..:    |...|.   |.
Mouse    68 --VDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTE---GE 127

  Fly   130 QLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELD 194
            ....:.|.|   :|..||..::....|..|..:|::......::.:::..|..|..|:....|..
Mouse   128 SQFVLQLRP---SLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENF 189

  Fly   195 LNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQH 259
            .:.:||.:|..:....:..||:...:..|....:|...||.....|.|||.||.:..:.||.:.|
Mouse   190 NDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIH 254

  Fly   260 AGTNITGLRLVSPDSEQVQEVA---KALYESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNF 321
            .|.|:||.:||..::..|.::.   |.|.:.|.|  ....|...:.||.||||.::|||::.:..
Mouse   255 GGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYP--GSETPPKYTSALTYDGVLVMAETFRSLRR 317

  Fly   322 RPVALS---------CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVS 377
            :.:.:|         .|..:.|.:|..:...:|.:.:.||||.::||:.|.|.::.::|.||..:
Mouse   318 QKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKST 382

  Fly   378 GMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEG 442
            |.:|:|.|:..|.....:.||  :|..|..::.|::.||.|.:..||.|.|:..|..||||::||
Mouse   383 GPRKVGYWNDMDKLVLIQDAP--TLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEG 445

  Fly   443 FGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESG 507
            :.::|..|::|.:|..|...:..|.|||..|..|..||||:.|::..:|::.|..||:|..||..
Mouse   446 YCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEV 510

  Fly   508 VDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEW-- 570
            :||:.|||||||.|:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:.:|::.|.||.||
Mouse   511 IDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT 575

  Fly   571 DNPYPCIEEPTEL-ENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTA 634
            :.|....|.|::. .|:|...|.||||:||.:|||.:::|::.|.|.|...|||||||::|||||
Mouse   576 EEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 640

  Fly   635 NLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYM 698
            |||||||||.:|:||..|:||:| :..:.||....|:|..||:.|....|::|:.:||. .|...
Mouse   641 NLAAFLTVERMVSPIESAEDLAK-QTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVF 704

  Fly   699 TNTNQEGVDRVENS--NYAFLMESTTIEYITERR-CTLTQVGALLDEKGYGIAMRKNWPYRDTLS 760
            |.|..|||.||..|  .:|||:|||..|||.:|: |...:||..||.||||:|..|....|..::
Mouse   705 TRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVN 769

  Fly   761 QAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGA----VALEISNLGGVFLVMGVGSFFGI 821
            .|||::.|.|:|.|:|.|||.:|   |.|  ..:|||:    .||.:||:.|||.::..|....:
Mouse   770 LAVLKLSEAGVLDKLKNKWWYDK---GEC--GPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAM 829

  Fly   822 FVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMSV 886
            .|:|:|                         |..:.....|.:|..|::...|.:|.....:::.
Mouse   830 LVALIE-------------------------FCYKSRAEAKRMKVAKSAQTFNPTSSQNTHNLAT 869

  Fly   887 DSLPEDTSEADASGKH 902
                  ..|||....|
Mouse   870 ------YREADFFRSH 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	100/375 (27%)
		ANF_receptor	53..374	CDD:279440	87/342 (25%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	168/376 (45%)
		Lig_chan	543..816	CDD:278489	126/283 (45%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	100/382 (26%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	171/384 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846392
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850