DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Gria2

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	868	Identity:	284/868 - (32%)
Similarity:	444/868 - (51%)	Gaps:	82/868 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLH 137
            ::|..|||..:...|....:.:.|:||.....:.....|.|....:.|:.      ...||...|
Mouse    64 NLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFIT------PSFPTDGTH 122

  Fly   138 P-----HPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYEL---- 193
            |     .|...| ||..::....|:.|..:|:|...|.|::.:|.       :...:::::
Mouse   123 PFVIQMRPDLKG-ALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLD-------SAAEKKWQVTAIN 179

  Fly   194 --DLNGN-----YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHT 251
              ::|.:     ||::.:.:....:...::......:.:...|...:|.....|.|||.||.:..
Mouse   180 VGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTD 244

  Fly   252 MDLEPYQHAGTNITGLRLVSPDSEQVQEVAK---ALYESEEPFQNVSCPLTNSMALVYDGVQLLA 313
            .||...|..|.|::|.::|..|...|.:..:   .|.|.|.|..: :..:..:.||.||.||::.
Mouse   245 GDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAH-TATIKYTSALTYDAVQVMT 308

  Fly   314 ETYKHVNFRPVALS---------CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKL 369
            |.::::..:.:.:|         .|....|.:|..:...:|.:.:.||:|.|:||..|.|.::.:
Mouse   309 EAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTI 373

  Fly   370 EVIELAVSGMQKIGQWSGEDGFQEN-RPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEK 433
            .::||..:|.:|||.||..|..... ...|:.:   |...|.||:.||.|.:..||.|:|:..|.
Mouse   374 NIMELKTNGPRKIGYWSEVDKMVVTLTELPSGN---DTSGLENKTVVVTTILESPYVMMKKNHEM 435

  Fly   434 LEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDL 498
            ||||:::||:.::|..|::|..||.|...:..|.|||..|..|..||||:.|::..:||:.|..|
Mouse   436 LEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPL 500

  Fly   499 TMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLG 563
            |:|..||..:||:.|||||||.|:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:.:|::.
Mouse   501 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 565

  Fly   564 RLSPAEWDNPYPCIEE--------PTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAAS 620
            |.||.||..     ||        .:|..|:|...|.||||:||.:|||.:::|::.|.|.|...
Mouse   566 RFSPYEWHT-----EEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 625

  Fly   621 WWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQ 685
            |||||||::||||||||||||||.:|:||..|:|||| :..:.||....|:|..||:.|....:.
Mouse   626 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSK-QTEIAYGTLDSGSTKEFFRRSKIAVFD 689

  Fly   686 RMYEFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITERR-CTLTQVGALLDEKGYG 746
            :|:.:||. .|.....|..|||.||..|  .||:|:|||..|||.:|: |...:||..||.||||
Mouse   690 KMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG 754

  Fly   747 IAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGA----VALEISNLG 807
            ||..|....|..::.|||::.|||:|.|:|.|||.:|...||     :|||:    .||.:||:.
Mouse   755 IATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGA-----KDSGSKEKTSALSLSNVA 814

  Fly   808 GVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNT------KAVKY 866
            |||.::..|....:.|:|:|..  .|.|::..::..........:..|..:|:|      ...::
Mouse   815 GVFYILVGGLGLAMLVALIEFC--YKSRAEAKRMKMTLSAATRNKARLSITGSTGENGRVMTPEF 877

  Fly   867 PKNSSRSNASSKSKGSSMSVDSL 889
            ||........|...|.::||..|
Mouse   878 PKAVHAVPYVSPGMGMNVSVTDL 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	79/345 (23%)
		ANF_receptor	53..374	CDD:279440	70/328 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	172/381 (45%)
		Lig_chan	543..816	CDD:278489	127/288 (44%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	79/348 (23%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	174/386 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850