DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grik and Gria1

DIOPT Version :9

Sequence 1:NP_001262788.1 Gene:Grik / 42476 FlyBaseID:FBgn0038840 Length:907 Species:Drosophila melanogaster
Sequence 2:NP_001106796.1 Gene:Gria1 / 14799 MGIID:95808 Length:907 Species:Mus musculus


Alignment Length:937 Identity:301/937 - (32%)
Similarity:477/937 - (50%) Gaps:107/937 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ASFPLGFILTSLLLAFPGCRGERTNVGLVYENTDPDLEKIFHLAISKANEENEDL-QLHGVSVSI 74
            |.|..||:...:...||    ....:|.::.|........|..|:|:..|..:.| |:..|::| 
Mouse     6 AFFCTGFLGAVVGANFP----NNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNIS- 65

  Fly    75 EPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFL------DTRWDFGAQLPT 133
               :|||.:.:.|....:.:.|:||...........|.|.|..:.|:      ||...|     .
Mouse    66 ---DSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQF-----V 122

  Fly   134 INLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGN 198
            :.|.|.   |..||..::....|::|..||::...|..::.:|.........||...........
Mouse   123 LQLRPE---LQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEG 184

  Fly   199 YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTN 263
            ||.:.:.:....:...||......|.....|..::......|.||:.||.:..:||..::.:|.|
Mouse   185 YRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGAN 249

  Fly   264 ITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLTN---------------SMALVYDGVQLLA 313
            :||.:||:             |....|.:.:....|:               :.||.||||:::|
Mouse   250 VTGFQLVN-------------YTDTIPARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVKVMA 301

  Fly   314 ETYKHVNFRPVALS---------CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKL 369
            |.::.:..:.:.:|         .|....|.:|..:...::.:...||||.::|:.:|.||::.|
Mouse   302 EAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTL 366

  Fly   370 EVIELAVSGMQKIGQWSGEDGFQENRPAPAHS-LEPDMRSLVNKSFVVITAISEPYGMLKETSEK 433
            .|||:...|::|||.|:.:|.|.   ||...: ...|..|:.|::::|.|.:.:||.|||:.:.:
Mouse   367 HVIEMKHDGIRKIGYWNEDDKFV---PAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQ 428

  Fly   434 LEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDL 498
            .||||::||:.:||..|::|.:|:||...:..|.|||..||.|..||||:.|::..|||:.:..|
Mouse   429 FEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPL 493

  Fly   499 TMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLG 563
            |:|..||..:||:.|||||||.|:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:.:|::.
Mouse   494 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 558

  Fly   564 RLSPAEWDNPYPCIEE-----PTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWF 623
            |.||.||.:..  .||     .::..|:|...|.||||:||.:|||.:::|::.|.|.|...|||
Mouse   559 RFSPYEWHSEE--FEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWF 621

  Fly   624 FTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMY 688
            ||||::||||||||||||||.:|:||..|:||:| :..:.||....|:|..||:.|....:::|:
Mouse   622 FTLIIISSYTANLAAFLTVERMVSPIESAEDLAK-QTEIAYGTLEAGSTKEFFRRSKIAVFEKMW 685

  Fly   689 EFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITERR-CTLTQVGALLDEKGYGIAM 749
            .:|:. .|.....|.:||:.||..|  .||:|:|||..|||.:|: |...:||..||.||||||.
Mouse   686 TYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIAT 750

  Fly   750 RKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGA----VALEISNLGGVF 810
            .|....|..::.|||::.|||:|.|:|:|||.:|   |.|  ..:|||:    .||.:||:.|||
Mouse   751 PKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDK---GEC--GSKDSGSKDKTSALSLSNVAGVF 810

  Fly   811 LVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVK---YPKNSSR 872
            .::..|....:.|:|:|..  .|.||:..:       :.....|.|.|.| :|::   .|:||..
Mouse   811 YILIGGLGLAMLVALIEFC--YKSRSESKR-------MKGFCLIPQQSIN-EAIRTSTLPRNSGA 865

  Fly   873 SNASSKSKGSS---------MSVDSLP 890
            ..:.....|.:         .|:.|:|
Mouse   866 GASGGSGSGENGRVVSQDFPKSMQSIP 892

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GrikNP_001262788.1 PBP1_iGluR_Kainate 37..391 CDD:107377 89/384 (23%)
ANF_receptor 53..374 CDD:279440 79/351 (23%)
Periplasmic_Binding_Protein_Type_2 411..781 CDD:304360 168/378 (44%)
Lig_chan 543..816 CDD:278489 123/285 (43%)
Gria1NP_001106796.1 PBP1_iGluR_AMPA_GluR1 26..389 CDD:107385 89/387 (23%)
ANF_receptor 37..372 CDD:279440 81/359 (23%)
PBP2_iGluR_AMPA_GluR1 406..787 CDD:270447 171/386 (44%)
Glutamate binding. /evidence=ECO:0000250 492..494 0/1 (0%)
Lig_chan 538..817 CDD:278489 123/286 (43%)