Protein Alignment Grik and Ir25a

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_319463.5
• Gene: Ir25a / 1279695
• VectorBaseID: AGAMI1_004282
• Length: 946
• Species: Anopheles gambiae
• Alignment Length: 1036
• Identity: 251/1036 - (24%)
• Similarity: 425/1036 - (41%)
• Gaps: 250/1036 - (24%)

  Fly     2 WFVKMISTEASFPLGFILTSLLLAFPGCRGERT-NVGLVYEN-TDPDLEKIFHLAISKA-NEENE 63
            |.|.:....||:.:..|:           |:.| |:.:::.| .|.:|..:   |:..| |...:
Mosquito     9 WLVLIPIQLASYAIIAIM-----------GQTTQNINILFVNEVDNNLANV---AVEVALNYVKK 59

  Fly    64 DLQLHGVSVSI--EPGN---SFETSKKLCKMLRQNLVAVFGP-------TSNLAARHAMSICDAK 116
            :.|| |:||.:  ..||   |.:..:.||....|:|.....|       .:.:::....|...|.
Mosquito    60 NPQL-GLSVDMMYVEGNRTDSKDLLQALCSKYGQSLSENRPPHLLLDTTLTGVSSETVKSFSLAL 123

  Fly   117 ELPFLDTRWDFGAQ---------LPT-----INLHPHPATLGVALRDMVVALGWESFTIIYESGE 167
            .:|.:..  .||.:         .||     :.:.|....:...:|.:::.:...:..|:|::..
Mosquito   124 GIPTVSA--SFGQEGDLRQWRDLTPTKRGYLLQVMPPADMIPQVIRSIIIYMNITNAAILYDNTF 186

  Fly   168 YLP-TVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQ 231
            .:. ..:.|||...|.....|:..     :.:..:.:.::||.|..:|.::||:|::.:..:.|:
Mosquito   187 VMDHKYKALLQNIPTRHVITTIAD-----DRDRASQIEKLRNLDINNFFILGSLASIKQVLESAK 246

  Fly   232 QVGLVTSDYRYIIGNLDWHTMDLEPYQHA----GTNITGLRLVSPDS--EQVQEVAKALYESEEP 290
            .        .|...|..||.:..|.....    ...|..||.:|..|  :::..:.......:||
Mosquito   247 N--------EYFERNFAWHVITQEQKDLTCNVENATIMFLRPMSDSSSKDRLGSIRTTYNLKQEP 303

  Fly   291 FQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCN--DDSAWDKGYTLVNYMKSLTLNGLT 353
                               |:....|..:..|.:....|  ...:|...      ||.:|..
Mosquito   304 -------------------QITGFFYFDLTLRALIAIKNILQSGSWPSN------MKYITCE--- 340

  Fly   354 GPIRFDYEGLRT-----DFKLEVIEL--------------------------------AVS---- 377
                 ||:|..|     |.|...||:                                |||
Mosquito   341 -----DYDGTNTPNHTIDLKTAFIEVTEPTTFGPFEIPKGGKMQFNGNTYMKFDMDINAVSIRSG 400

  Fly   378 ---GMQKIGQWSGEDGFQENRPAPAH-SLEPDMRSL-VNKSFVVITAISEPYGMLKETSEKLEGN 437
               ..:.:|.|      :.:..||.: :.|.::::| .:..:.|.|.:..|:.|...|:.|
Mosquito   401 ASVNTRSLGTW------EASLNAPINVANEAEIKNLTADVVYRVYTVVQAPFIMRDPTAPK---- 455

  Fly   438 DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTS 502
             .|:|:.|:|::::::.:.|.|..|..||.|:|.:: :.|||||::|::||.:||:|:..:::.:
Mosquito   456 -GFKGYCIDLLNKIAEIVEFDYEIREVEDGKFGNMN-ENGEWNGIVRKLIDKQADIGLGSMSVMA 518

  Fly   503 ERESGVDFTIPFMSL-GIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLS 566
            |||:.:|||:|:..| ||.|:.:.| ..|..||.|::.....|||.:..||...|..|::..|.|
Mosquito   519 ERETVIDFTVPYYDLVGISIMMQLP-STPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRYS 582

  Fly   567 PAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSS 631
            |..:.|.....:...| :.:|:...||||.:.:|..||...|||..|.|.|||:||.|..|:::|
Mosquito   583 PYSYQNNREKYKNDDE-KREFNIKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIAS 646

  Fly   632 YTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKES----------------- 679
            |||||||||||..|.||:...||||| :..:.|....|.:...:|:..
Mosquito   647 YTANLAAFLTVSRLDTPVESLDDLSK-QYKILYAPLNGSSAMTYFQRMADIEAKFYEIWKEMSLN 710

  Fly   680 --------------NYPT---YQRMYEFMRDNPQYMTNTNQEGVDRVEN----SNYAFLMESTTI 723
                          :||.   |.:|::.|.:  ..:.|:.:|.|.|:.|    |.:|||.::|.|
Mosquito   711 DSLTAVERSKLAVWDYPVSDKYTKMWQAMLE--AGLPNSLEEAVQRIRNSTSASGFAFLGDATDI 773

  Fly   724 EYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGA 788
            .|.....|.|..||.....|.|.||:::..|.:|..:.|:|.:..:..|.|:|.:||:.......
Mosquito   774 RYQVLTNCDLQMVGEEFSRKPYAIAVQQGSPLKDQFNNAILMLLNRRELEKLKEQWWKNDDVQNK 838

  Fly   789 CSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEM----------VLGVKERSDENQVSF 843
            |...|:.|..::  |.|:||||:|:.||........|.|.          |:.|.|.:|:..
Mosquito   839 CEKPDDQSDGIS--IQNIGGVFIVIFVGIGMACITLLFEFWYYKYRNNSKVIDVAESTDQQH--- 898

  Fly   844 KTELLDEIRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMSVDSLPEDTSEADASGKHNH 904
                           |.| .||          :.:..|..|..|||.:.|.      .||:
Mosquito   899 ---------------GGT-IVK----------NVRPAGKLMKQDSLKDSTK------GHNY 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	77/440 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	132/408 (32%)
Ir25a	XP_319463.5	None