Protein Alignment Grik and Nmdar2

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_061504088.1
• Gene: Nmdar2 / 1275196
• VectorBaseID: AGAMI1_003064
• Length: 910
• Species: Anopheles gambiae
• Alignment Length: 870
• Identity: 202/870 - (23%)
• Similarity: 346/870 - (39%)
• Gaps: 220/870 - (25%)

  Fly   132 PTINLHPHPATLGVALRDMVVALGWESFTIIYES----GEYLPTVRELLQMYGTAGPTVTVRRYE 192
            |:|. |...|.|.:..|     ..|..|:::...    .:::..|||
Mosquito    53 PSIE-HQSAAMLSILER-----YKWHQFSVVTSQIAGHDDFVQAVRE------------------ 93

  Fly   193 LDLNGNYRNVLRRIRNADDFSFVVVGS-MATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEP 256
                        ::...|.|.|.::.| :.|.|     :..:.||.|:.|.::  |.....:...
Mosquito    94 ------------QVGAMDHFKFTILNSIIVTRP-----SDLLELVNSEARVML--LYCTKSEAIE 139

  Fly   257 YQHAG--TNITGLRLVSPDSEQVQEVAKALYESEEP------------FQNVSCPLTNSMAL--- 304
            ..||.  ..|||       ...|..|.:::.|:.:.            |...|..|.|.:|.
Mosquito   140 ILHAAEELQITG-------ENYVWVVTQSVIENTQTHPQFPIGMLGVHFDTSSGALVNEIATAIR 197

  Fly   305 VYD-GVQLLAETYKHVNFR--PVALSCNDD--SAWDKGYTLVNYMKSLTLNGLTGP--IRFDYEG 362
            ||. ||:......|:...|  ...|||.|.  ..||.|.....|:::::|...:..  |.|..:|
Mosquito   198 VYAYGVEYYLNDVKNTGRRLDTHQLSCEDQGRGRWDSGEVFFKYLRNVSLESESNKPNIEFTADG 262

  Fly   363 LRTDFKLEVIELAVS----GM--QKIGQWSGEDGFQENR--------PAPAHSLEPDMRSLVNKS 413
            .....:|:::.|..|    |:  ::||.|.   .:|:.:        |..:|:   ..:.:..|.
Mosquito   263 DLKSAELKIMNLRPSVNSKGLVWEEIGIWK---SWQQQKLDIRDIAWPGNSHT---PPQGVPEKF 321

  Fly   414 FVVITAISE-PY-----------------GMLKETSEKLE----------GNDQF----EGFGIE 446
            .:.||.:.| ||                 |:|...:...|          .|..|    .||.|:
Mosquito   322 HLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMTDIDMGQAHKNGSFYQCCSGFCID 386

  Fly   447 LIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFT 511
            |:::.:::|||:|.....||.|:|.::  .|:|||::.|:::.:.||.:|.|.:.:|||:.|||:
Mosquito   387 LLEKFAEELGFTYELVRVEDGKWGTLE--NGKWNGLIHELVNRKTDMVLTSLMINAEREAVVDFS 449

  Fly   512 IPFMSLGIGILF--RKPMKEPPKLFSFMSPFSGEVWLWLGL-AYMGVSISMFVLGRLSPAEWDNP 573
            .|||..||.|:.  |..:..|.   :|:.||....|:.:|: |....:..:|:...|||:.:|
Mosquito   450 EPFMETGIAIVVAKRTGIISPT---AFLEPFDTASWMLVGIFAIQAATFMIFLFEWLSPSGYD-- 509

  Fly   574 YPCIEEPTELEN------QFSFANCLWFSIGALLQQGSEL-APKAYSTRAVAASWWFFTLILVSS 631
                 ..|.|:|      :||.....|.....|.|....: :|:.:::|.:...|..|.::.::.
Mosquito   510 -----MKTVLQNGQTTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWAMFAVVFLAI 569

  Fly   632 YTANLAAFLTVESLVTPINDADD--LS---KNKGGVNYG----AKIGGATFNFFKESNYPTYQRM 687
            ||||||||:............||  ||   .:|..:.:|    :........:|||.:|
Mosquito   570 YTANLAAFMITREEFHEFTGLDDSRLSHPFSHKPTIKFGTIPWSHTDSTISKYFKEMHY------ 628

  Fly   688 YEFMRDNPQYMTNTNQEGVDRVENSNY-AFLMESTTIEYITER--RCTLTQVGALLDEKGYGIAM 749
              :|:   ||..::..:||..|.:... ||:.:.|.::|:.::  .|.|..||......|||:|.
Mosquito   629 --YMK---QYNRSSVADGVTAVLSGQLDAFIYDGTVLDYLVQQDEDCRLLTVGQWYAMTGYGLAF 688

  Fly   750 RKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADED---SGAVALEISNLGGVFL 811
            .:|..|....::.:||.:..|.|.:::..|..     |.|....::   |..:|||  .....||
Mosquito   689 SRNSKYVGMFNKRLLEFRANGDLERLRRFWMT-----GTCRPGKQEHKSSDPLALE--QFLSAFL 746

  Fly   812 VMGVGSFFGIFVSLLEMV--------LGVKER---------SDENQVSFK------TELL----- 848
            ::..|......:.|||.:        |..|:|         |....::|:      ||:|
Mosquito   747 LLMAGILLAALLLLLEHLYFKYFRKRLAKKDRGGCCALISLSMGKSLTFRGAVYEATEILRRHRC 811

  Fly   849 -DEIRFILQCSGNTKAVKYPKNSSR 872
             |.|     |..:...||:..:.||
Mosquito   812 NDPI-----CDTHLWKVKHELDMSR 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	61/297 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	112/423 (26%)
Nmdar2	XP_061504088.1	None