Protein Alignment Grik and Ir93a

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_061512014.1
• Gene: Ir93a / 1272000
• VectorBaseID: AGAMI1_007780
• Length: 876
• Species: Anopheles gambiae
• Alignment Length: 966
• Identity: 205/966 - (21%)
• Similarity: 356/966 - (36%)
• Gaps: 251/966 - (25%)

  Fly     3 FVKMISTEASFPLGFILTSLLLAFPGCRGERTNVGLVYENTDPDLEKIFHLAISKANEENEDLQL 67
            |..::||.||  :..||            :|..:|..||.|..:.:.:....|      .|.|:.
Mosquito    30 FPSLLSTNAS--MAIIL------------DREYLGADYERTLDETKNVVEKLI------REHLKN 74

  Fly    68 HGV--------SVSIEPGNSFETSKKLCK--------MLRQNLVAVFGPTSNLAARHAMSICDAK 116
            .|:        |::::...|...|...||        .:|:.||             .:||.| .
Mosquito    75 GGLIVKYYSWTSINLKRDFSAVLSVSSCKNTWDIYQEAVRERLV-------------MLSITD-P 125

  Fly   117 ELPFLDTRWDFGAQLPTINLHPHPATLGVA----------LRDMVV--ALGWESFTIIYE---SG 166
            :.|          :|||.|....|.:.|..          :.||..  |:.|.:.|::|:   ..
Mosquito   126 DCP----------RLPTNNAIMIPRSDGSGSNAFDEVSQIILDMKSSRAINWHTATLLYDQVYDA 180

  Fly   167 EYLPTVRELLQ-MYGTAGPTVTVRRYELDLNG-----NYRNVLRRI----------RNADDFSFV 215
            |....:..||: ..|....|:|    |..:|.     ..|..:||.          ||     |:
Mosquito   181 EISRCILSLLEDREGIKPLTLT----EFKINAPTHSWEKRKEIRRTLLGIPTAYTGRN-----FI 236

  Fly   216 VVGSMATLPEFFKQAQQVGLVT--SDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQ 278
            .:.::|||....:.::.:.||.  :.:.|:|.|.          :.|.:|.|....:..:.:.|.
Mosquito   237 AIVNIATLTLLMEISKDLKLVNPFAQWLYLIPNT----------EKANSNFTTQSTLINEGDNVA 291

  Fly   279 EVAKALYESEEPFQN----VSC--------------PLTNSMALVYDGVQLLAETYKHVNFRP-- 323
            .|    |.|....||    |.|              .|.....:|:.  |:..|.::.:  ||
Mosquito   292 FV----YNSGSKAQNCTVSVLCYIESYLLHFIRSLSKLIREEQVVFG--QISDEEWEII--RPSK 348

  Fly   324 ------------VALS----CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVI 372
                        .|::    ||..|.|.        ::|....|..         .||||..:..
Mosquito   349 QERKTKFLQMIKAAITSKDECNKCSQWK--------IQSAETWGYV---------YRTDFLTDGA 396

  Fly   373 ELAVS---GMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKL 434
            :|...   .|..||.||.:|||........|: :...|.:   ..:..:..:.|:       :.:
Mosquito   397 DLQERRKYTMLDIGYWSPQDGFMLTDALFPHT-QYGFRGV---QLIFYSYHNPPW-------QFV 450

  Fly   435 EGNDQ-----FEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLRE--------- 485
            ..||.     ..|...::::|||:||.|:||..:.:          ..|.||.|.|
Mosquito   451 AYNDSGSPVISSGVVYDILNELSRKLNFTYTMVISQ----------PAEINGSLVEGNTSSVYDL 505

  Fly   486 --------------IIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSF 536
                          :::::..:.....|:..:::..|.||.|........:..:| :|..::..|
Mosquito   506 KTISSDIPQEIFSTLVNNKILLAAVGATVNEKQKKFVSFTDPISIQTYSFVISRP-RELSRVLLF 569

  Fly   537 MSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALL 601
            :|||..:.||.|..|...:...:..:.:|||.     |....:||: .......||.|:..||||
Mosquito   570 LSPFGSDTWLCLAAAVALMGPILCAINKLSPY-----YEVHNKPTD-TGLGKVNNCFWYIYGALL 628

  Fly   602 QQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGA 666
            |||....|.|.|.|.:..:||...|::|::|..||.||||...:..|:|....|.:|..|:.:..
Mosquito   629 QQGGLYLPYADSGRIIIGTWWLVVLVIVTTYCGNLVAFLTFPKIDIPVNRVMQLLRNDRGMTWSI 693

  Fly   667 KIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSNYAFLMESTTIEYITER-- 729
            :.|........:|..|.|.::|:    ..|.:.....|.|:|:|...:..:.....:.|:.:|
Mosquito   694 RRGTFLEEMLMDSTEPKYMQLYK----GSQIIGELTDELVERIEAGQHVHIDWRNNLRYLMKRQF 754

  Fly   730 ----RCTLT-QVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEK---RGG 786
                ||... .....|||: ..:.|.|:.||.:.:::.:..|.:.|.:.:...::...|   .|.
Mosquito   755 LRTDRCDFALSTDEFLDEQ-IALVMPKDSPYLELVNEEIKRMHQFGFIQRWVAQYLPAKDKCSGT 818

  Fly   787 GACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVS 842
            |...|....:    :..|::.|.:.::.:|...|:||.:.|..:....:|...|.:
Mosquito   819 GRVMDVQNHT----VNSSDMAGSYWILLLGFVSGLFVFVCEFAVAWYRKSRAAQAA 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	91/447 (20%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	91/404 (23%)
Ir93a	XP_061512014.1	None