Protein Alignment Grik and GRIN3B

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_619635.1
• Gene: GRIN3B / 116444
• HGNCID: 16768
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 164/690 - (23%)
• Similarity: 266/690 - (38%)
• Gaps: 139/690 - (20%)

  Fly   283 ALYESEEPFQNVSCPLTNSMALVYDGVQLL-------AETYKHVNFRPVALSCND---DSAWDKG 337
            ||.|...|      ||.   |.::|.|||:       |:........|..::|.|   ......|
Human   280 ALGEVARP------PLE---AAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPG 335

  Fly   338 YTLVNYMKSLTLNGLTGPI------------RFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDG 390
            ..|..::.:.:..|.|||:            .|....||.|.: .....|..|..:.||...|.|
Human   336 RFLARFLANTSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPR-GAPAWATVGSWRDGQLDLEPG 399

  Fly   391 FQENRPAPAHSLE--PDMRSLVNKSFVVITAISEPYGMLKETSEKLEG-------------NDQF 440
            ....||.|....:  |.:|        |:|.:..|:...::..|  :|             ||..
Human   400 GASARPPPPQGAQVWPKLR--------VVTLLEHPFVFARDPDE--DGQCPAGQLCLDPGTNDSA 454

  Fly   441 E----------------------GFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGML 483
            .                      |:.|:|::.|::...|.:...|..|.|||.:  :.|.|.|::
Human   455 TLDALFAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGAL--RDGRWTGLV 517

  Fly   484 REIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWL 548
            .:::..||.|.:|..::.|.|...||||.||.|..:||:.|......| :.:||.|.....||
Human   518 GDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTWL-- 579

  Fly   549 GLAYMGVSISMFVLGR-LSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQG-SELAPKA 611
                 ||..::.:... |:..||.:||............||:::.|......|.::. |...||.
Human   580 -----GVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKC 639

  Fly   612 YSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADD--LSKNKGGVNYGAKIGGATFN 674
            .:.|.:...|..|.|:::|||||||||.:..:.....::...|  |.....|..:|.....:...
Human   640 PTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEA 704

  Fly   675 FFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSN---YAFLMESTTIEY--ITERRCTLT 734
            :.|:|    :..|:..||   ::...|...||..:.:..   .||:|:.:.::|  ..:..|.|.
Human   705 YIKKS----FPDMHAHMR---RHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLL 762

  Fly   735 QVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAV 799
            .||.....:||||.:.:|.|....||:.:...:..|.:..:..||::....|.......|.
Human   763 TVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTET---- 823

  Fly   800 ALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAV 864
                       |.|.:..|.|:|| ||.:.||....|...:.:|....|..||       ....:
Human   824 -----------LQMSIYHFAGLFV-LLCLGLGSALLSSLGEHAFFRLALPRIR-------KGSRL 869

  Fly   865 KYPKNSS----RSNASSKSKGSSMSVDSLPEDTSEADASG 900
            :|..::|    |:..:...:||.       |:|:||:.||
Human   870 QYWLHTSQKIHRALNTEPPEGSK-------EETAEAEPSG 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	31/133 (23%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	100/413 (24%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	29..401	CDD:380600	31/130 (24%)
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	101/419 (24%)
		Lig_chan	574..841	CDD:459656	70/296 (24%)