DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grik and GRIN3A

DIOPT Version :9

Sequence 1:NP_001262788.1 Gene:Grik / 42476 FlyBaseID:FBgn0038840 Length:907 Species:Drosophila melanogaster
Sequence 2:NP_597702.2 Gene:GRIN3A / 116443 HGNCID:16767 Length:1115 Species:Homo sapiens


Alignment Length:962 Identity:197/962 - (20%)
Similarity:360/962 - (37%) Gaps:255/962 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ASFPLGFILT----------SLLLAFPGCRGERTNVGLV-----------------YENTDPDLE 48
            :|.|..|:.:          |.|||||..:||...:.||                 .|:.:|   
Human   174 SSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNP--- 235

  Fly    49 KIFHLAISKANEENEDLQLHGVSVSI-EPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSI 112
              .||.:|..|..:.|..   |:||| ...|.:..|..||:. ..|:......|.|.:..|..||
Human   236 --LHLQLSLENSLSSDAD---VTVSILTMNNWYNFSLLLCQE-DWNITDFLLLTQNNSKFHLGSI 294

  Fly   113 CDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELL- 176
                                 ||:..:                             ||:.::|| 
Human   295 ---------------------INITAN-----------------------------LPSTQDLLS 309

  Fly   177 ----QMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVT 237
                |:......|.||..:..|:..     :|||                    |:...|.|::.
Human   310 FLQIQLESIKNSTPTVVMFGCDMES-----IRRI--------------------FEITTQFGVMP 349

  Fly   238 SDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK-----ALYESEEPFQNV-SC 296
            .:.|:::|                           ||:.|:|:..     .|....:..|:| ..
Human   350 PELRWVLG---------------------------DSQNVEELRTEGLPLGLIAHGKTTQSVFEH 387

  Fly   297 PLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWD--KGYTLVNYMKSLTLNGLTGPIRFD 359
            .:.::|.||...|.........:...|..::|.:....:  .|..|..::.:.|..||:|.||..
Human   388 YVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVK 452

  Fly   360 YEGLRTD------FKLEVIELAVSGMQKIGQWSG----------EDGFQENRPAPAHSLEPDMR- 407
            ...:.:.      :.|:...:......::|.|.|          .:..|.::....|..:..:| 
Human   453 GSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRV 517

  Fly   408 -SLVNKSFVVITAISE----PYGML--------KETSEKL-----EGND----QFE----GFGIE 446
             :|:...||....:.:    |.|.|        ..|.:.|     ..||    :|:    |:.|:
Human   518 VTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCID 582

  Fly   447 LIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFT 511
            |::::::.:.|.:...:..|.|||..  |.|.|.|::.:::...|.|.:|..::.:.|...:|||
Human   583 LLEKIAEDMNFDFDLYIVGDGKYGAW--KNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFT 645

  Fly   512 IPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLG-RLSPAEWDNPYP 575
            .||.|..:|||.|......| :.:||.|....:||       |:.:::.:.. .|:..||.:|:.
Human   646 SPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWL-------GIFVALHITAVFLTLYEWKSPFG 702

  Fly   576 CIEEPTELENQFSFANCLWFSIGALLQQGSELA---PKAYSTRAVAASWWFFTLILVSSYTANLA 637
            ...:.......|||::.|  :|...|..|..:|   ||.::.|.:...|..|.:..:|:||||||
Human   703 LTPKGRNRSKVFSFSSAL--NICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLA 765

  Fly   638 AFLTVESLVTPINDADD--LSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTN 700
            |.:..|.:...::...|  |.....|..:|.....:..::.::|    :..|:|:||   :|...
Human   766 AVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQS----FPEMHEYMR---RYNVP 823

  Fly   701 TNQEGVDRVENSNY---AFLMESTTIEY--ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLS 760
            ...:||:.::|...   ||:|:...::|  ..:..|.|..||.....:||||.:..|.|....:|
Human   824 ATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANIS 888

  Fly   761 QAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSL 825
            :.:.:.:..|.:..:..||::....|.......|   .:.:.|.:..|:|:::.:|....|..::
Human   889 ELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTE---TLQMGIKHFSGLFVLLCIGFGLSILTTI 950

  Fly   826 LEMVL------GVKERS---------------------DENQVSFKTELLDE 850
            .|.::      .:|.:|                     :|.|..|||:.:::
Human   951 GEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEK 1002

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GrikNP_001262788.1 PBP1_iGluR_Kainate 37..391 CDD:107377 67/400 (17%)
ANF_receptor 53..374 CDD:279440 59/340 (17%)
Periplasmic_Binding_Protein_Type_2 411..781 CDD:304360 100/405 (25%)
Lig_chan 543..816 CDD:278489 65/283 (23%)
GRIN3ANP_597702.2 PBP1_iGluR_NMDA_NR3 30..497 CDD:107372 78/433 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..118
ANF_receptor 127..469 CDD:279440 74/405 (18%)
PBP2_iGluR_NMDA_Nr3 512..908 CDD:270438 101/414 (24%)
Lig_chan 676..942 CDD:278489 65/284 (23%)
PPP2CB binding site. /evidence=ECO:0000250 951..987 3/35 (9%)
GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7 1062..1095
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155950
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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