Protein Alignment Grik and GRIN3A

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_597702.2
• Gene: GRIN3A / 116443
• HGNCID: 16767
• Length: 1115
• Species: Homo sapiens
• Alignment Length: 962
• Identity: 197/962 - (20%)
• Similarity: 360/962 - (37%)
• Gaps: 255/962 - (26%)

  Fly    11 ASFPLGFILT----------SLLLAFPGCRGERTNVGLV-----------------YENTDPDLE 48
            :|.|..|:.:          |.|||||..:||...:.||                 .|:.:|
Human   174 SSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNP--- 235

  Fly    49 KIFHLAISKANEENEDLQLHGVSVSI-EPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSI 112
              .||.:|..|..:.|..   |:||| ...|.:..|..||:. ..|:......|.|.:..|..||
Human   236 --LHLQLSLENSLSSDAD---VTVSILTMNNWYNFSLLLCQE-DWNITDFLLLTQNNSKFHLGSI 294

  Fly   113 CDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELL- 176
                                 ||:..:                             ||:.::||
Human   295 ---------------------INITAN-----------------------------LPSTQDLLS 309

  Fly   177 ----QMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVT 237
                |:......|.||..:..|:..     :|||                    |:...|.|::.
Human   310 FLQIQLESIKNSTPTVVMFGCDMES-----IRRI--------------------FEITTQFGVMP 349

  Fly   238 SDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK-----ALYESEEPFQNV-SC 296
            .:.|:::|                           ||:.|:|:..     .|....:..|:| ..
Human   350 PELRWVLG---------------------------DSQNVEELRTEGLPLGLIAHGKTTQSVFEH 387

  Fly   297 PLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWD--KGYTLVNYMKSLTLNGLTGPIRFD 359
            .:.::|.||...|.........:...|..::|.:....:  .|..|..::.:.|..||:|.||..
Human   388 YVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVK 452

  Fly   360 YEGLRTD------FKLEVIELAVSGMQKIGQWSG----------EDGFQENRPAPAHSLEPDMR- 407
            ...:.:.      :.|:...:......::|.|.|          .:..|.::....|..:..:|
Human   453 GSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRV 517

  Fly   408 -SLVNKSFVVITAISE----PYGML--------KETSEKL-----EGND----QFE----GFGIE 446
             :|:...||....:.:    |.|.|        ..|.:.|     ..||    :|:    |:.|:
Human   518 VTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCID 582

  Fly   447 LIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFT 511
            |::::::.:.|.:...:..|.|||..  |.|.|.|::.:::...|.|.:|..::.:.|...:|||
Human   583 LLEKIAEDMNFDFDLYIVGDGKYGAW--KNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFT 645

  Fly   512 IPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLG-RLSPAEWDNPYP 575
            .||.|..:|||.|......| :.:||.|....:||       |:.:::.:.. .|:..||.:|:.
Human   646 SPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWL-------GIFVALHITAVFLTLYEWKSPFG 702

  Fly   576 CIEEPTELENQFSFANCLWFSIGALLQQGSELA---PKAYSTRAVAASWWFFTLILVSSYTANLA 637
            ...:.......|||::.|  :|...|..|..:|   ||.::.|.:...|..|.:..:|:||||||
Human   703 LTPKGRNRSKVFSFSSAL--NICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLA 765

  Fly   638 AFLTVESLVTPINDADD--LSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTN 700
            |.:..|.:...::...|  |.....|..:|.....:..::.::|    :..|:|:||   :|...
Human   766 AVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQS----FPEMHEYMR---RYNVP 823

  Fly   701 TNQEGVDRVENSNY---AFLMESTTIEY--ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLS 760
            ...:||:.::|...   ||:|:...::|  ..:..|.|..||.....:||||.:..|.|....:|
Human   824 ATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANIS 888

  Fly   761 QAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSL 825
            :.:.:.:..|.:..:..||::....|.......|   .:.:.|.:..|:|:::.:|....|..::
Human   889 ELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTE---TLQMGIKHFSGLFVLLCIGFGLSILTTI 950

  Fly   826 LEMVL------GVKERS---------------------DENQVSFKTELLDE 850
            .|.::      .:|.:|                     :|.|..|||:.:::
Human   951 GEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEK 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	68/406 (17%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	100/405 (25%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	78/432 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	101/414 (24%)
		Lig_chan	674..941	CDD:459656	65/285 (23%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		3/35 (9%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1062..1095