DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and LOC110438919

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_021328141.1	Gene:	LOC110438919 / 110438919	-ID:	-	Length:	1417	Species:	Danio rerio

Alignment Length:	824	Identity:	176/824 - (21%)
Similarity:	333/824 - (40%)	Gaps:	155/824 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 WESFTII--YESG--EYLPTVRELLQMYGTAGPTVTVRRYEL---DLNGNYRNVLRRIRNADDFS 213
            |..|:|:  |..|  :::..:|..::..........|...::   |.:...:|:|:::::.
Zfish    25 WYIFSIVTTYYPGYQDFVTKIRSTIENSFVGWELEEVLLLDMSVDDGDAKIQNLLKKLQSP---- 85

  Fly   214 FVVVGSMATLPE---FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSE 275
              |:...:|..|   .|:.|..|||....|.:|:.:|.....|..|.:..    ||:..||.|..
Zfish    86 --VILLYSTKEEANIIFQVAHSVGLTGYGYTWIVPSLVAGDADHIPAEFP----TGMISVSYDEW 144

  Fly   276 QVQEVAKALYESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWDKG-YT 339
            .        |..|              |.|.|||.::|             :.......|:| :|
Zfish   145 D--------YGLE--------------ARVRDGVAVIA-------------TATSTMMMDRGPHT 174

  Fly   340 L----------------------VNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGM-QK 381
            |                      :.|:.::|..|..  :.|..:|.:...||.:|.|..... .:
Zfish   175 LLKSECHGAPDKKSPMTGNNNEVLRYLMNVTFEGRN--LSFSEDGYQMHPKLVIILLDKERQWDR 237

  Fly   382 IGQWSGEDGFQENRPAPAHSL-------EPDMRSLV---NKSFVVITAISEPYGMLKETS----E 432
            :|:|.......:....|...|       |.|..|:|   ...||::..:....|.....:    :
Zfish   238 VGKWENGSLSMKYHVWPRFELYSGPEAREDDHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRK 302

  Fly   433 KLEGNDQFE-----------GFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREI 486
            :|:..:|.:           ||.|:::.:::|.:.|:|...|..:.|:|  ....|.||||:.|:
Zfish   303 QLKALNQTQDSAVYIKRCCKGFCIDILKKIAKNVKFTYDLYLVTNGKHG--KKINGTWNGMVGEV 365

  Fly   487 IDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGL 550
            :...|.|.:..||:..||...:||::||:..||.::. |......|.  :|:.|||.:||:.:.:
Zfish   366 VLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGTVSPS--AFLEPFSADVWIMMFV 428

  Fly   551 AYMGVS-ISMFVLGRLSPAEWDNPYPCIEEPTELEN-QFSFANCLWFSIGALLQQGSELA-PKAY 612
            ..:.|| |::|:....||..::.   |:.:..|... .|:....:|...|.:......:. |:..
Zfish   429 MLLLVSAIAVFIFEYFSPVGYNR---CLADGREAGGPSFTIGKAIWLLWGLVFNNSVPVQNPRGT 490

  Fly   613 STRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFK 677
            :::.:.:.|.||.:|.::|||||||||:..|..|..::...| .|.:...::     ...|.|..
Zfish   491 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSD-KKFQNPNDF-----SPPFRFGT 549

  Fly   678 ESNYPTYQRMYEFMRDNPQYMTNTNQ----EGVDRVENSNY-AFLMESTTIEYITER--RCTLTQ 735
            ..|..|.:.:....||...||...:|    |.::.::.... ||:.::..:.|:..|  .|.|..
Zfish   550 VPNGSTERNIRNNYRDMHSYMVKFHQRNVVEALESLKTGKLDAFIYDAAVLNYMAGRDEGCKLVT 614

  Fly   736 VGA--LLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGA 798
            :|:  :....|||||::|:..::..:..|:|::...|.:.:::..|..     |.|.....:..:
Zfish   615 IGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT-----GICHHEKNEVMS 674

  Fly   799 VALEISNLGGVFLVMGVGSFFGIFVSLLEMV---------LGVKERSDENQVSFKTELLDEIRFI 854
            ..|::.|:.|||.::|......:...:.|.|         :||.........:...|:...|..:
Zfish   675 SQLDVDNMAGVFYMLGAAMALSLITFIAEHVFYWHMRFCFMGVCSGKPGFTFTISREIYSCIHGV 739

  Fly   855 LQCSGNTKAVKYPK---NSSRSN-----ASSKSKGSSMSVDSLP 890
             :....:.|:..|.   |::.||     .::|:..|...|:..|
Zfish   740 -EIEDKSSALNSPSATMNNTHSNILRLLRTAKNMASLSGVNGSP 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	51/268 (19%)
		ANF_receptor	53..374	CDD:279440	48/250 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	96/397 (24%)
		Lig_chan	543..816	CDD:278489	66/284 (23%)
LOC110438919	XP_021328141.1	PBP1_iGluR_NMDA_NR2	<1..255	CDD:107373	51/276 (18%)
		PBP2_iGluR_NMDA_Nr2	267..667	CDD:270436	101/417 (24%)
		DUF4013	<389..478	CDD:315788	24/93 (26%)
		NMDAR2_C	704..1417	CDD:313729	14/80 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591267
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840