DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and grik3

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_031752773.1	Gene:	grik3 / 100498426	XenbaseID:	XB-GENE-6050069	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	887	Identity:	336/887 - (37%)
Similarity:	509/887 - (57%)	Gaps:	65/887 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 CRG--ERTNVGLVYENTDPDL-------EKIFHLAISKANEENEDLQLHGVSVSIEPGN---SFE 81
            |:|  ....:|.::|:.:...       |:.|..:.|..|.....|....::..|:..|   |||
Frog    29 CQGMPHVIRIGGIFEHLEGPTGQLVSAEEQAFRFSASIINRNRTLLPNTTLTYDIQRINLYDSFE 93

  Fly    82 TSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRW---------DFGAQLPTINLH 137
            .::|.|..|...:||:|||:.:.::....|||:|.|:|.:..||         .|     .:||:
Frog    94 ANRKACDQLALGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWKHHPLDNRDSF-----YVNLY 153

  Fly   138 PHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDL------- 195
            |..|:|..|:.|:|..|.|.|.|::|:....|..::||:         :...||.:.|
Frog   154 PDYASLSHAILDLVQFLKWRSATVVYDDSTGLIRLQELI---------MAPARYNIRLKIRQLPP 209

  Fly   196 -NGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQH 259
             :.:.|.:|:.::...:|..:...|.....:..:||..:|::|..|.||...||.:.:|||||::
Frog   210 ESEDARPLLKEMKRGREFRIIFDCSHTMAAQILRQAMAMGMMTEYYHYIFTTLDLYALDLEPYRY 274

  Fly   260 AGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCP--------LTNSMALVYDGVQLLAETY 316
            :|.|:||.|:::.|:..|..:....  |.|..|....|        :|...||.||.|.:::..|
Frog   275 SGVNLTGFRILNVDNPYVSSIVDKW--SMERHQATPKPESGLLDGIMTTDAALTYDAVHIVSVCY 337

  Fly   317 KHVNFRPV-ALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFD-YEGLRTDFKLEVIELAVSGM 379
            :......| :|.|:...||..|...:|::|.....||||.|.|: ..||||||.|::|.|...|:
Frog   338 QRAPQMTVNSLQCHRHKAWRFGSRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGL 402

  Fly   380 QKIGQWSGEDGFQENRPAPAHSLEPDM-RSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGF 443
            :|:|.|:..||.  |....|....|:: .||.|::.:|.|.:.|||.|.|.:...|.|.|:||||
Frog   403 EKVGTWNPSDGL--NITETARGRGPNISESLTNRTLIVTTVLEEPYVMFKRSDTPLFGKDRFEGF 465

  Fly   444 GIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGV 508
            .|:|:.::::.|||.|..||.||.|||..|.| |:|||:::|:||.:||:.:..||:|..||..:
Frog   466 CIDLLKKIAEILGFDYDIRLVEDAKYGSQDEK-GQWNGLVKELIDHKADLAVAPLTITHVREKVI 529

  Fly   509 DFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNP 573
            ||:.|||:|||.||:||.....|.:|||::|.|.::|:::.|||:|||..:||:.|.||.||.:.
Frog   530 DFSKPFMTLGISILYRKANGTAPSVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYDA 594

  Fly   574 YPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAA 638
            :||......:||.|:..|..||::|||:||||||.|||.|||.:...|||||||::|||||||||
Frog   595 HPCNPGTDVVENNFTLLNSFWFAVGALMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAA 659

  Fly   639 FLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQ 703
            |||||.:.:.|:.||||:| :..:.|||.:.|||.||||:|:..|:::|:.||...|..:..:|:
Frog   660 FLTVERMESAIDSADDLAK-QTKIEYGAVVDGATMNFFKKSHISTFEKMWAFMSSRPSALVKSNE 723

  Fly   704 EGVDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQE 768
            ||:.||.:::||.|||||.|||||:|.|.|||:|.|:|.|||||......||||.:|.|:|::||
Frog   724 EGIQRVLSADYALLMESTAIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDRISIAILQLQE 788

  Fly   769 QGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVK 833
            ...:.|||.:||   |.|| |.: :::..|.||.|.|:||:|:|:..|....:.|::.|.|..::
Frog   789 ADEIHKMKERWW---RSGG-CPE-EKNKEASALGIQNMGGIFIVLAGGLILSVVVAMAEFVYKLR 848

  Fly   834 ERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNA 875
            :.::..|.||.:.:.||||..|.|....|....|....:|:|
Frog   849 KTAEREQRSFCSTMADEIRLSLTCQRRVKHKPQPPVMVKSDA 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	112/390 (29%)
		ANF_receptor	53..374	CDD:279440	102/350 (29%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	185/369 (50%)
		Lig_chan	543..816	CDD:278489	137/272 (50%)
grik3	XP_031752773.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930