DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and grik5

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_002936446.1	Gene:	grik5 / 100497490	XenbaseID:	XB-GENE-953974	Length:	995	Species:	Xenopus tropicalis

Alignment Length:	957	Identity:	330/957 - (34%)
Similarity:	507/957 - (52%)	Gaps:	123/957 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGFILTSLLLAF--PG------------------C-RGERTNVGLVYENTDPDLEKIFHLAISKA 58
            ||..|..|||:|  ||                  | ||||..:.|..|          |:
Frog     6 LGAPLLLLLLSFTSPGVSLLSSLRVAAILDDQTVCGRGERLALALARE----------HI----- 55

  Fly    59 NEENEDLQLHGVSVSI---EPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMS-ICDAKELP 119
            |...:......|.|.|   :..:.:||:..:|::|.:.:|:|.||:::.|:...:| ||..||:|
Frog    56 NSHTQGSASGRVEVEIFELQKDSQYETTDTMCQILPKGVVSVLGPSTSPASASTVSHICGEKEIP 120

  Fly   120 FLDTRWDFGAQL-----PTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMY 179
            .:....:...:|     .:::|:|....:.:|:..::.:....|.::|....|.|..:.||::.:
Frog   121 HIKVGPEEAPKLQYLRFASVSLYPSNEDISLAVSHILKSFHNPSTSLICAKAECLLRLEELVRQF 185

  Fly   180 GTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPE-FFKQAQQVGLVTSDYRYI 243
            ..:..|::||.  ||.:.:...:|:.||: |..|.:::.:.||:.. ..|:|.::|:.::.|:||
Frog   186 LISKDTLSVRM--LDESNDPTPLLKEIRD-DKVSTIIIDANATVSHLILKKASELGMTSAHYKYI 247

  Fly   244 IGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQ-------NVS----CP 297
            :..:|:..:.||......:||.|.               ::|.|..||.       |:|    |.
Frog   248 LTTMDFPLLSLEGIVSDQSNILGF---------------SMYNSSHPFYLEFLRSLNMSWRENCE 297

  Fly   298 LTN------SMALVYDGVQLLAETYKHVN----FRPVALSCNDDSAWDKGYTLVNYMKSLTLNGL 352
            |:.      |.||::|.|.::....:.:|    .....|||:....|..|.:|:||::.:..:||
Frog   298 LSTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKQLSCSTSQIWQHGTSLMNYLRMVEYDGL 362

  Fly   353 TGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDM---RSLVNKSF 414
            ||.:.|:.:|.||::.|.::|.|..|.::||.|      ..||....::...|:   .:|.||:.
Frog   363 TGRVEFNSKGQRTNYTLRILEKAGDGHREIGVW------YSNRTLAMNATSLDLSTSETLENKTL 421

  Fly   415 VVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEW 479
            ||.|.:..||.|.|.....|.||||:|||..|::.||:..|.|:|..:|.||..||..:| .|.|
Frog   422 VVTTILENPYMMRKSNYRSLSGNDQYEGFCAEMLMELAALLRFNYKIKLVEDGLYGAPEP-NGSW 485

  Fly   480 NGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEV 544
            .||:.|:|:.:||:.:...|:|:|||..:||:.|||:|||.||:|..|...|..|||:.|||..|
Frog   486 TGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVQMGRKPGYFSFLDPFSPAV 550

  Fly   545 WLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTE-LENQFSFANCLWFSIGALLQQGSELA 608
            ||::.|||:.||..:|:..||||.||.||:||:.|... ||||::..|.|||.:|..:|||||:.
Frog   551 WLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRERHHILENQYTLGNSLWFPVGGFMQQGSEVM 615

  Fly   609 PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATF 673
            |:|.|||.|:..||.||||::|||||||||||||:.:..||..||||: ::..:.||...||:|.
Frog   616 PRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESADDLA-DQTNIEYGTIHGGSTM 679

  Fly   674 NFFKESNYPTYQRMYEFMRD-NPQYMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVG 737
            .||:.|.|.|||||:.:|.. .|.....:.:||:.||.||.||||:|||..||.....|.|||:|
Frog   680 TFFQNSRYQTYQRMWNYMNSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIG 744

  Fly   738 ALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALE 802
            .|||.|||||.|....||||.::.|:|::||...|..:|.|||:    ||.| ..:||..|..|.
Frog   745 GLLDTKGYGIGMPLGSPYRDEITLAILQLQENNRLEILKRKWWE----GGKC-PKEEDHRAKGLG 804

  Fly   803 ISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYP 867
            :.|:||:|:|:..|....:||:::|.|...:...|..::|...|:|.|:|..:.|
Frog   805 MENIGGIFVVLICGLIIAVFVAIMEFVWSTRRSVDNEEISVCQEMLSELRSAVSC---------- 859

  Fly   868 KNSSRSNASSKSK-----GSSMSVDSLPEDTSEAD-ASGK----HNH 904
            |.:|||....:..     .:.:|:...|..|.|.. .:|:    |.|
Frog   860 KKTSRSRHRRRPPRHLHGRTLLSLSRPPRSTRETRLCNGRLYQTHQH 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	93/384 (24%)
		ANF_receptor	53..374	CDD:279440	84/351 (24%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	183/371 (49%)
		Lig_chan	543..816	CDD:278489	135/274 (49%)
grik5	XP_002936446.1	PBP1_iGluR_Kainate_KA1_2	27..405	CDD:380616	100/416 (24%)
grik5	XP_002936446.1	Periplasmic_Binding_Protein_Type_2	418..788	CDD:389745	183/371 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930