Protein Alignment Grik and grik2

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_017949808.1
• Gene: grik2 / 100495093
• XenbaseID: XB-GENE-5902331
• Length: 913
• Species: Xenopus tropicalis
• Alignment Length: 845
• Identity: 332/845 - (39%)
• Similarity: 497/845 - (58%)
• Gaps: 42/845 - (4%)

  Fly    48 EKIFHLAISKANEE-----NEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAAR 107
            |..|..|::..|..     |..|......:::.  :|||.|:|.|:.|...:.|:|||:.:.:|.
 Frog    59 ELAFRFAVNTINRNRTLLPNTTLTYDTQRINLY--DSFEASRKACEQLSLGVAAIFGPSHSSSAN 121

  Fly   108 HAMSICDAKELPFLDTRWDFGAQLPT------INLHPHPATLGVALRDMVVALGWESFTIIYESG 166
            ...|||:|..:|.:.|||..  |:..      ::|:|..::|..|:.|:|....|::.||.|:..
 Frog   122 AVQSICNALGVPHIQTRWKH--QVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTIAYDDS 184

  Fly   167 EYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQ 231
            ..|..::||::........:.:|:..:|.. :.:.:|:.::...:|..:...|........|||.
 Frog   185 TGLIRLQELIKAPSRYNLRLKIRQLPIDTK-DAKPLLKEMKRGKEFHVIFDCSHDMAAGILKQAL 248

  Fly   232 QVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSC 296
            .:|::|..|.||...||...:|:|||:::|.|:||.|:::.::.||..:.:..  |.|..|....
 Frog   249 AMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNIENSQVLSIIEKW--SMERLQAPPK 311

  Fly   297 P--------LTNSMALVYDGVQLLAETYKHVNFRPV-ALSCNDDSAWDKGYTLVNYMKSLTLNGL 352
            |        :|...||:||.|.:::...:......| :|.||....|..|...::.:|.....||
 Frog   312 PDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGARFISLIKEAHWEGL 376

  Fly   353 TGPIRFD-YEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQ--ENRPA-PAHSLEPDMRSLVNKS 413
            ||.|.|: ..||||||.|:||.|...|::|||.|....|..  ||:.. ||:..:    ||.|:|
 Frog   377 TGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPTSGLNMTENQKGKPANITD----SLSNRS 437

  Fly   414 FVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGE 478
            .:|.|.:.|||.|.|::.:.|.|..:|||:.|:|:::|||.|||.|..||.||.|||..|..|.:
 Frog   438 LIVTTILEEPYVMFKKSDKPLYGKARFEGYCIDLLEKLSKILGFEYEVRLVEDGKYGAKDDTTQQ 502

  Fly   479 WNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGE 543
            ||||:||::|.:||:.:..|.:|..||..:|||.|||:|||.||:|||....|.:|||::|.|.:
 Frog   503 WNGMVRELMDHKADLAVAPLAITYVREQVIDFTKPFMTLGISILYRKPNGTNPGVFSFLNPLSPD 567

  Fly   544 VWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELA 608
            :|:::.|||:|||..:||:.|.||.||.||:||..:...:||.|:..|..||.:|||:||||||.
 Frog   568 IWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM 632

  Fly   609 PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATF 673
            |||.|||.|...|||||||::||||||||||||||.:.:||:.||||:| :..:.|||...|||.
 Frog   633 PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAK-QTKIEYGAVQDGATM 696

  Fly   674 NFFKESNYPTYQRMYEFMRDNPQ-YMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVG 737
            .|||:|..|||::|:.||....| .:...|:||:.||..|:|||||||||||::|:|.|.|||:|
 Frog   697 TFFKKSRIPTYEKMWAFMNSRSQSVLVKNNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIG 761

  Fly   738 ALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALE 802
            .|:|.||||:......||||.::.|:|::||:|:|..||.|||   ||.| |.: :|...|.||.
 Frog   762 GLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGVLHMMKEKWW---RGNG-CPE-EESKEASALG 821

  Fly   803 ISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYP 867
            :.|:||:|:|:..|....:||::.|.:...|:.:...:.||.:.:::|:|..|:|....|....|
 Frog   822 VQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQP 886

  Fly   868  867
             Frog   887  886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	106/369 (29%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	194/370 (52%)
grik2	XP_017949808.1	PBP1_iGluR_Kainate	42..419	CDD:380605	105/366 (29%)
		Periplasmic_Binding_Protein_Type_2	435..805	CDD:473866	195/373 (52%)