DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and grik2

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_017949808.1	Gene:	grik2 / 100495093	XenbaseID:	XB-GENE-5902331	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	845	Identity:	332/845 - (39%)
Similarity:	497/845 - (58%)	Gaps:	42/845 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 EKIFHLAISKANEE-----NEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAAR 107
            |..|..|::..|..     |..|......:::.  :|||.|:|.|:.|...:.|:|||:.:.:|.
Frog    59 ELAFRFAVNTINRNRTLLPNTTLTYDTQRINLY--DSFEASRKACEQLSLGVAAIFGPSHSSSAN 121

  Fly   108 HAMSICDAKELPFLDTRWDFGAQLPT------INLHPHPATLGVALRDMVVALGWESFTIIYESG 166
            ...|||:|..:|.:.|||..  |:..      ::|:|..::|..|:.|:|....|::.||.|:..
Frog   122 AVQSICNALGVPHIQTRWKH--QVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTIAYDDS 184

  Fly   167 EYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQ 231
            ..|..::||::........:.:|:..:|.. :.:.:|:.::...:|..:...|........|||.
Frog   185 TGLIRLQELIKAPSRYNLRLKIRQLPIDTK-DAKPLLKEMKRGKEFHVIFDCSHDMAAGILKQAL 248

  Fly   232 QVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSC 296
            .:|::|..|.||...||...:|:|||:::|.|:||.|:::.::.||..:.:..  |.|..|....
Frog   249 AMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNIENSQVLSIIEKW--SMERLQAPPK 311

  Fly   297 P--------LTNSMALVYDGVQLLAETYKHVNFRPV-ALSCNDDSAWDKGYTLVNYMKSLTLNGL 352
            |        :|...||:||.|.:::...:......| :|.||....|..|...::.:|.....||
Frog   312 PDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGARFISLIKEAHWEGL 376

  Fly   353 TGPIRFD-YEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQ--ENRPA-PAHSLEPDMRSLVNKS 413
            ||.|.|: ..||||||.|:||.|...|::|||.|....|..  ||:.. ||:..:    ||.|:|
Frog   377 TGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPTSGLNMTENQKGKPANITD----SLSNRS 437

  Fly   414 FVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGE 478
            .:|.|.:.|||.|.|::.:.|.|..:|||:.|:|:::|||.|||.|..||.||.|||..|..|.:
Frog   438 LIVTTILEEPYVMFKKSDKPLYGKARFEGYCIDLLEKLSKILGFEYEVRLVEDGKYGAKDDTTQQ 502

  Fly   479 WNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGE 543
            ||||:||::|.:||:.:..|.:|..||..:|||.|||:|||.||:|||....|.:|||::|.|.:
Frog   503 WNGMVRELMDHKADLAVAPLAITYVREQVIDFTKPFMTLGISILYRKPNGTNPGVFSFLNPLSPD 567

  Fly   544 VWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELA 608
            :|:::.|||:|||..:||:.|.||.||.||:||..:...:||.|:..|..||.:|||:||||||.
Frog   568 IWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM 632

  Fly   609 PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATF 673
            |||.|||.|...|||||||::||||||||||||||.:.:||:.||||:| :..:.|||...|||.
Frog   633 PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAK-QTKIEYGAVQDGATM 696

  Fly   674 NFFKESNYPTYQRMYEFMRDNPQ-YMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVG 737
            .|||:|..|||::|:.||....| .:...|:||:.||..|:|||||||||||::|:|.|.|||:|
Frog   697 TFFKKSRIPTYEKMWAFMNSRSQSVLVKNNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIG 761

  Fly   738 ALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALE 802
            .|:|.||||:......||||.::.|:|::||:|:|..||.|||   ||.| |.: :|...|.||.
Frog   762 GLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGVLHMMKEKWW---RGNG-CPE-EESKEASALG 821

  Fly   803 ISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYP 867
            :.|:||:|:|:..|....:||::.|.:...|:.:...:.||.:.:::|:|..|:|....|....|
Frog   822 VQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQP 886

Fly 868 867
Frog 887 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	104/363 (29%)
		ANF_receptor	53..374	CDD:279440	96/341 (28%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	194/370 (52%)
		Lig_chan	543..816	CDD:278489	143/273 (52%)
grik2	XP_017949808.1	PBP1_iGluR_Kainate	42..419	CDD:380605	105/366 (29%)
grik2	XP_017949808.1	Periplasmic_Binding_Protein_Type_2	435..805	CDD:419667	195/373 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010