Protein Alignment Grik and grin2b

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 1037
• Identity: 214/1037 - (20%)
• Similarity: 407/1037 - (39%)
• Gaps: 229/1037 - (22%)

  Fly     6 MISTEASFPLGFILTSLLLAFPGCRGER---TNVGLVYENTDPDLEKIFHLAISKANEENEDLQL 67
            |..|||...|...|  ::|.:.||..::   .::.::...|..:      :||...:|:::   .
 Frog     1 MRPTEACCYLKISL--IILFYMGCYAQKHPNMDIAVILVGTTDE------VAIKDVHEKDD---F 54

  Fly    68 HGVSVSIEPGNSFETSK---------KLCKMLRQNLV--AVFG---------------------P 100
            |.:.|:  |..:..|..         ::|.::....|  .|||                     |
 Frog    55 HHLPVT--PRVALVTMNESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTP 117

  Fly   101 TSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTII--Y 163
            ...:....:|.:.|.:|....   :.||   |:|...      ...:.:::....|..|:|:  |
 Frog   118 ILGIHGGSSMIMADKEEASMF---FQFG---PSIEQQ------ASVMLNIMEEYDWYIFSIVTTY 170

  Fly   164 ESG--EYLPTVRELLQMYGTAGPTVTVRRYELDLNGN---YRNVLRRIRNADDFSFVVVGSMATL 223
            ..|  ::...||..::..........|...::.|:.|   .:|.|:::::.      |:....|.
 Frog   171 FPGYQDFENKVRSTIENSFVGWELEEVIHLDMSLDDNDSKIQNQLKKLQSP------VILLYCTK 229

  Fly   224 PE---FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALY 285
            .|   .|:.|..|||....|.:|:.:|.....|..|.:..    |||..||.|.          :
 Frog   230 EEATYIFEVAHSVGLTGYGYTWIVPSLVAGDTDTVPAEFP----TGLISVSYDE----------W 280

  Fly   286 ESEEPFQNVSCPLTNSMALVYDGVQLL---AETY--KHVNFRPVALSCND--DSAWDKGYTLVNY 343
            :.:.|            |.|.||:.::   |.|.  :|.:......||.:  :|...:.:.|..|
 Frog   281 DYDLP------------ARVRDGIAIITTAASTMLSEHNSIPQSKSSCYNIQESRVYEAHMLKRY 333

  Fly   344 MKSLTLNGLTGPIRFDYEGLRTDFKLEVIEL-AVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMR 407
            :.::|..|..  :.|..:|.:...||.:|.| .....:::|::.......:....|...|.|:..
 Frog   334 LINVTFEGRN--LSFSEDGYQMHPKLVIILLNQQRKWERVGKYKDRSLKMKYYVWPVFELYPNSE 396

  Fly   408 SLVNKSFVVITAISEPYGMLKE--------------------TSEKLEGNDQF-----EGFGIEL 447
            ...::...::|....|:.::::                    |..:.|....:     :||.|::
 Frog   397 EHKDEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIRTENRTEEGGNYIKRCCKGFCIDI 461

  Fly   448 IDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTI 512
            :.:::|.:.|:|...|..:.|:|  ....|.||||:.|::..||.|.:..||:..||...|||::
 Frog   462 LKKIAKTVKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSV 524

  Fly   513 PFMSLGIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVS-ISMFVLGRLSPAEWDNPYP 575
            ||:..||.::. |......|.  :|:.|||.:||:.:.:..:.|| :::||....||..::.
 Frog   525 PFIETGISVMVSRSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNR--- 584

  Fly   576 CIEEPTELEN-QFSFANCLWFSIGALLQQGSELA-PKAYSTRAVAASWWFFTLILVSSYTANLAA 638
            |:.:..|... .|:....:|...|.:......:. ||..:::.:.:.|.||.:|.::||||||||
 Frog   585 CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAA 649

  Fly   639 FLTVESLVTPINDADDLSKNK-----GGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYM 698
            |:..|..|..::...|....:     ....:|....|:|....:.:    |..|:       .||
 Frog   650 FMIQEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNN----YLEMH-------SYM 703

  Fly   699 TNTNQEGVD---------RVENSNYAFLMESTTIEYITER--RCTLTQVGA--LLDEKGYGIAMR 750
            ...||..|.         :::    ||:.::..:.|:..|  .|.|..:|:  :....|||||::
 Frog   704 VKFNQRSVQDALLSLKTGKLD----AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQ 764

  Fly   751 KNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGV 815
            |:..::..:..|:|::...|.:.:::..|..     |.|.:...:..:..|:|.|:.|||.::..
 Frog   765 KDSGWKRQVDLAILQLFGDGEMEELEALWLT-----GICHNEKNEVMSSQLDIDNMAGVFYMLAA 824

  Fly   816 GSFFGIFVSLLEMV---------LGVKERSDENQVSFKTELLDEIRFILQC------SGNTKAVK 865
            .....:...::|.:         :||  .|.:..|.|...     |.|..|      .....|:.
 Frog   825 AMALSLITFIMEHLFFWQLRHCFMGV--CSGKPGVVFSIS-----RGIYSCIHGVPIEDRQSAMN 882

  Fly   866 YPK---NSSRSN-----ASSKSKGSSMSVDSLPE-------------DTSEADASGKHNHGK 906
            .|.   |::.||     .::|:..:...|:..|:             |.||...|..|:..|
 Frog   883 SPSATMNNTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCK 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	74/409 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	97/416 (23%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	74/411 (18%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	99/426 (23%)
		NMDAR2_C	837..1449	CDD:463148	22/115 (19%)