Protein Alignment Grik and grin2a

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_031749422.1
• Gene: grin2a / 100489006
• XenbaseID: XB-GENE-992741
• Length: 1450
• Species: Xenopus tropicalis
• Alignment Length: 998
• Identity: 214/998 - (21%)
• Similarity: 390/998 - (39%)
• Gaps: 229/998 - (22%)

  Fly    36 VGLVYENTDPDLEKIFHLAISKANEENEDL----QLHGVSVSIEPGNSFETSKKLCKMLRQNLVA 96
            |.|:...|||. ..|.|:.         ||    ::|||..    |:..: .:.:.::|......
 Frog    62 VTLLVNQTDPK-SIITHVC---------DLMSGTKIHGVVF----GDDTD-QEAIAQILDFVSSQ 111

  Fly    97 VFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTI 161
            .|.|...:....:|.:.|..|   :.|.:.|||.:         ....:.:.:::....|..|:|
 Frog   112 TFIPILGIHGGSSMIMADKDE---MSTFFQFGASI---------KQQAIVMLNIMEEYDWHVFSI 164

  Fly   162 IYESGEYLPTVRELLQMYGTAGPTVTVR---RYELDLNGNYRNV-----LRRIRNA--------D 210
            |..:   .|..|:.:....|......|.   :..:.|:.:|.:.     |::|.::        |
 Frog   165 ITST---FPGYRDFISFIKTTVDNSFVGWEVQNVITLDTSYTDARTLTQLKKIHSSVILLYCSKD 226

  Fly   211 DFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSE 275
            :.:::           |.:|:.:||:...:.:|:.:|.....|:.||:..    :||..||.|..
 Frog   227 EANYI-----------FVEARSLGLMGYGFVWIVPSLVTGNTDIIPYEFP----SGLVSVSYDDW 276

  Fly   276 QVQEVAKALYESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWDKG--Y 338
            .               .|:...:.:.:.::......:.|  ||........||...:..::.  :
 Frog   277 D---------------YNIEARVRDGLGIITTAASAMLE--KHSVIPEAKTSCYAQNERNEPPLH 324

  Fly   339 TLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVS-GMQKIGQWSGEDGFQENR------- 395
            ||..:|.::|.:|  ..:.|..:|.:.:.||.|:.|.:. ..:|:|:|       ||:
 Frog   325 TLHKFMINVTWDG--KDLSFTEDGYQANPKLVVLLLNMDREWEKVGKW-------ENKSLNMKYP 380

  Fly   396 --PAPAHSLEPD-------MRSLVNKSFVVITAIS--------------EPYGMLKETSEKLEGN 437
              |....||:.|       :.:|....||::..:.              :.:.:...|:|.....
 Frog   381 VWPRITASLDSDPDDNHLSIVTLEEAPFVIVENVDYLTGTCVRNTVPCRKYFRLNNSTTEGTSVK 445

  Fly   438 DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTS 502
            ...:||.|:::.:|||.:.|:|...|..:.|:|  ......||||:.|::..||.|.:..||:..
 Frog   446 KCCKGFCIDILKKLSKTVKFTYDLYLVTNGKHG--KKIKNVWNGMIGEVVYKRAVMAVGSLTINE 508

  Fly   503 ERESGVDFTIPFMSLGIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVS-ISMFVLGRL 565
            ||...|||::||:..||.::. |......|.  :|:.|||..||:.:.:..:.|| :::||....
 Frog   509 ERSEAVDFSVPFVETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLLVSAVAVFVFEYF 571

  Fly   566 SPAEW-----DNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELA-PKAYSTRAVAASWWFF 624
            ||..:     |...|  ..|:     |:....:|...|.:......:. ||..:::.:.:.|.||
 Frog   572 SPVGYNRNLADGKAP--HGPS-----FTIGKAVWLLWGLVFNNSVPVQNPKGTTSKIIVSIWAFF 629

  Fly   625 TLILVSSYTANLAAFLTVESLVTPINDADDLSKNK-----GGVNYGAKIGGATFNFFKESNYPTY 684
            .:|.::|||||||||:..|..|..:....|....:     ....:|....|:|....: :|||
 Frog   630 AVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR-NNYP-- 691

  Fly   685 QRMYEFMRDNPQYMTNTNQEGV-DRVENSNY----AFLMESTTIEYITER--RCTLTQVGA--LL 740
                    |..|||...:|:|| |.:.:...    ||:.::..:.|:..|  .|.|..:|:  :.
 Frog   692 --------DMHQYMVKFHQKGVQDALVSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIF 748

  Fly   741 DEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISN 805
            ...|||||::|...::..:..|:|:....|.:.:::..|..     |.|.....:..:..|:|.|
 Frog   749 ATTGYGIALQKGSRWKRPIDLALLQFVGDGEMEELEKLWLT-----GICHTEKNEVMSSQLDIDN 808

  Fly   806 LGGVFLVM--------------------------GV-----GSFFGIFVSLLEMVLGV--KERSD 837
            :.|||.::                          ||     |..|.|...:...:.||  :|:..
 Frog   809 MAGVFYMLAAAMALSLITFVWEHLFYWKLRYCFTGVCTGTPGLLFSISRGIYSCIHGVHIEEKKK 873

  Fly   838 ENQVSF---KTELLDEIRFI-----------LQCSGNTKAVKYPKNSS--------RSNASSKSK 880
            ....||   :|.:|..:|..           .||:...:...|.:.:|        :.|.|....
 Frog   874 SPDFSFTASQTNMLKLLRASKNIANLSNLNQSQCNSPKRTSDYIQRNSLLMDMVLDKGNLSYSDN 938

  Fly   881 GSSMSVDSLPEDTSE-ADASGKH 902
            ......|...|:|.: |..||.|
 Frog   939 RPFQQKDVYSENTYDLAMLSGNH 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	71/381 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	103/405 (25%)
grin2a	XP_031749422.1	PBP1_iGluR_NMDA_NR2	26..379	CDD:380601	72/387 (19%)
		PBP2_iGluR_NMDA_Nr2	395..793	CDD:270436	105/424 (25%)
		NMDAR2_C	831..1450	CDD:463148	26/131 (20%)