DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and LOC100334689

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_017206939.1	Gene:	LOC100334689 / 100334689	-ID:	-	Length:	991	Species:	Danio rerio

Alignment Length:	902	Identity:	330/902 - (36%)
Similarity:	510/902 - (56%)	Gaps:	66/902 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VGLVYENTDPDL------EKIFHLAISKANEENEDLQLHGVSVSIEPGN---SFETSKKLCKMLR 91
            :|.::|.||..:      |..|..|::..|.....|....::..|:..|   |||.|:|.|..|.
Zfish    33 IGGIFEQTDGPVALVSSEELAFKFAVNNINRNRTLLPNTTLTYDIQRINIYDSFEASRKACDQLS 97

  Fly    92 QNLVAVFGPTSNLAARHAMSICDAKELPFLDTRW---------DFGAQLPTINLHPHPATLGVAL 147
            ..:||:|||:.:.::....|||:|.|:|.:..||         .|.|     ||:|..::|..|:
Zfish    98 LGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWKHHPMDNRDTFYA-----NLYPDYSSLSYAI 157

  Fly   148 RDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDF 212
            .|:|..|.|::.|::|:....|..::||:.........:.:|:..:| ..:.|.:|:.::.:.:|
Zfish   158 LDLVQFLKWKTATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPMD-TVDTRPLLKEMKRSREF 221

  Fly   213 SFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQV 277
            ..:...|.....:..||||.:|::|..|.||...||...::||||:..|.|:||.|:::.|:.||
Zfish   222 RIIFDCSHTMAAQILKQAQMMGMMTEYYHYIFTTLDLMAINLEPYRFCGVNMTGFRILNVDNPQV 286

  Fly   278 QE-VAKALYESEEP-------FQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPV-ALSCNDDSA 333
            .. |.|...|.:.|       .:.:   :|...||.||.|.:::.:|:|.....| :|.|:....
Zfish   287 ASIVEKWSLERQIPPKPDSGLLEGI---MTTDAALTYDAVHIVSVSYQHAPQMTVNSLQCHRHKP 348

  Fly   334 WDKGYTLVNYMKSLTLNGLTGPIRFD-YEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPA 397
            |..|...::::|....:||||.:.|: ..||||||.|:::.|...|:||:|:||...|..... .
Zfish   349 WRFGGRFMSFIKESHWDGLTGRLCFNRTTGLRTDFDLDIVSLKEDGLQKVGKWSASGGLNITE-V 412

  Fly   398 PAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWR 462
            |..:......||.|:|.|:.|.:.|||.|||::.:.|.|||:||||.|:|:.||:..|||||...
Zfish   413 PRQNGMNITDSLSNRSLVITTILEEPYVMLKKSDKALVGNDRFEGFCIDLLKELASILGFSYEIH 477

  Fly   463 LQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPM 527
            |..|.|||..|.| |:||||:||:::.|||:.:..||:|..||..:||:.||::.||.||:|||.
Zfish   478 LVPDGKYGFQDDK-GQWNGMIRELMEHRADLAVAPLTITFMREKAIDFSKPFLNTGISILYRKPN 541

  Fly   528 KEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANC 592
            ......|||::|.:.::|:::.|||:|||..:||:.|.||.||.:.:||......:||.|:..|.
Zfish   542 STNSGFFSFLNPMTPDIWVYILLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSDVVENNFTLLNS 606

  Fly   593 LWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSK 657
            .||.:|:|:||||||.|||.|||.:...|||||||::||||||||||||||.:.:|::.||||:|
Zfish   607 FWFGVGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMDSPVDSADDLAK 671

  Fly   658 NKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFM--RDNPQYMTNTNQEGVDRVENSNYAFLMES 720
             :..:.||....|||.:|||:|...|:::|:.||  |.:..::.:. ::|:.||..|:||.||||
Zfish   672 -QTKIEYGVVKDGATMSFFKKSRVSTFEKMWAFMSSRQSTSFVKSI-EDGIQRVLKSDYALLMES 734

  Fly   721 TTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRG 785
            |||||:|.|.|.|||||.::|.|||||...|..||||.::.|:|.:.|.|.|..:|.|||    .
Zfish   735 TTIEYVTRRNCNLTQVGGIIDSKGYGIGTPKGSPYRDKITIAILGILEDGRLHMLKEKWW----S 795

  Fly   786 GGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDE 850
            |.:|.: ||......:.|.||||:|:|:..|....:||::.|.:..:::.::..||
Zfish   796 GSSCLE-DERYETGPMGIQNLGGIFIVLASGLVLSVFVAIGEFIYKLRKTAEREQV--------- 850

  Fly   851 IRFILQC-SGNTKAVKYPKNSSRSN----ASSKSKGSSMSVDSLPEDTSEADASGKH 902
               .||| .|..:.|.:.:.:..:.    |:|.::.......:|.:..|.| ..|:|
Zfish   851 ---FLQCGDGRDQTVVHVRETGEAQAPPAAASHAEDGRSDQHALLQRPSPA-RKGQH 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	113/381 (30%)
		ANF_receptor	53..374	CDD:279440	100/342 (29%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	183/371 (49%)
		Lig_chan	543..816	CDD:278489	131/274 (48%)
LOC100334689	XP_017206939.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591305
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760