DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and grin3bb

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_017213803.2	Gene:	grin3bb / 100333101	ZFINID:	ZDB-GENE-131122-77	Length:	1114	Species:	Danio rerio

Alignment Length:	962	Identity:	218/962 - (22%)
Similarity:	371/962 - (38%)	Gaps:	224/962 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ASFPLG---FILTSLLLAFPG------CR-----GERTNVG-LVYENTDPDLEKIFHLAISKANE 60
            |.|.||   |:|.:|||..|.      |.     |....:| |:.......:....|.|:|...|
Zfish    10 AYFYLGSQIFLLHTLLLLQPAHSHPQPCHILARIGHTVRLGALLPPRQSVRVRAALHRALSGLAE 74

  Fly    61 ENEDLQLHGVSVSI-----EPGNSFETSKKLCK-MLRQNLVAVFG-PTSNLAARHAMSICDAKEL 118
            ...:...:.:|:.:     :.|:.....:.:|: ::.|.:.||.. |.:.........:....|:
Zfish    75 SGNNFLPYNLSLDVVAREAQSGDPESLFRCVCQDIVVQGVSAVLAFPQTQEEIVQMEFMSSFLEI 139

  Fly   119 PFLDTRWDFGAQLPTINLHPHPATLGV---ALRDMVVAL----GWESFTIIYESGEYLPTVRELL 176
            ||:.. .:.|..|.|.|......|..:   .|.::::|:    |||....:...|.....:.:||
Zfish   140 PFISI-IEHGEPLKTQNRFHLQMTTRIPPSGLVELLLAVLQRSGWEESMAVLCHGWEDAGLLDLL 203

  Fly   177 QMYGTA--GPTVTVRRYELDLNGNYRNVLRRIRNADDF-------------SFVVVGSMATLPE- 225
            ::.|..  ||:....|..|:|:    :...|:.|..||             |.::.|:.   ||
Zfish   204 KLQGRFGWGPSQWHLRAALNLS----HSTARMANISDFLSEHFNLDHSPPASVLLFGAD---PEC 261

  Fly   226 ---FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYES 287
               ..:.|..:||......:|:|:         |             :|||:
Zfish   262 ASSVLRSAHDLGLTLPTVHWIMGH---------P-------------LSPDA------------- 291

  Fly   288 EEPFQNVSCPLTNSMALVY-------------DGVQLL--AETYKHVNFRPVALSCNDDSAWDK- 336
               ..::..||.   .|.|             |.:||:  |.|...|....:||..|..:.:||
Zfish   292 ---LHSIGLPLG---LLAYGEVDHKPLDFYISDALQLINRAVTAATVVRPDLALIQNMVNCFDKP 350

  Fly   337 --------GYTLVNYMKSLTLNGLTGP--IRFDYEGLRTDFKLEVIELAVSGMQK-----IGQWS 386
                    |..:..::.:.:..|||||  ::.:...:.|..|:.:..|....:.:     :|.|.
Zfish   351 NKHELPSSGQYIARFLSNTSFVGLTGPVIVQRNLSRVHTSHKVHIWSLRRDAVGQPTWVTVGSWE 415

  Fly   387 G------EDGFQENRPAPAHSLEPDMR--------------------SLVNKSFVVITAISE--- 422
            |      |.|..:. .:|....|..|.                    :||...||....:.|
Zfish   416 GGRLNVEEQGLWQG-SSPRQRTEGQMGREGRRWRAGFPVSGSRLRVVTLVEHPFVFTREVDEDGN 479

  Fly   423 -PYGML--------KET-----SEKLEGNDQF---------EGFGIELIDELSKKLGFSYTWRLQ 464
             |.|..        .||     :|:.:||..|         .|:.|:|:::||:.:.|.:...:.
Zfish   480 CPAGQYCLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEKLSEDMNFEFDLYIV 544

  Fly   465 EDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKE 529
            .|.|||.:  |.|:|.|::.:::...|||.:|..::.|.|...:|||.||.|..:|||.|.....
Zfish   545 GDGKYGAV--KGGQWTGLVGDLLSGVADMAVTSFSINSARSKVIDFTSPFFSTSLGILVRSKDTA 607

  Fly   530 PPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGR-LSPAEWDNPYPCIEEPTELENQFSFANCL 593
            .| :.:||.|....:|       ||:.:::.:... |:..||.:|:............||:::.|
Zfish   608 AP-IGAFMWPLHWSMW-------MGIFVALHITALFLTLYEWKSPFGMTPHGRNRVKVFSYSSAL 664

  Fly   594 WFSIGALL-QQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESL---VTPINDADD 654
            ......|. :..|...||.::.|.:...|..|.|:::|||||||||.:..|..   |:.|:|| .
Zfish   665 NLCYAILFGRTVSSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDA-K 728

  Fly   655 LSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSN---YAF 716
            |.....|..:|.....:..::.|:|    :..|:|:||   ::...|..:||..::...   .||
Zfish   729 LHHPSQGFRFGTVRESSAEDYMKKS----FPEMHEYMR---KFNEPTTPDGVATLKTDPPQLDAF 786

  Fly   717 LMESTTIEY--ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKW 779
            :|:...::|  ..:..|.|..||.....:||||.:.:|.|....:|:.|...:..|.:..:..||
Zfish   787 IMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNISEFVSRYKSDGYMDMLHDKW 851

  Fly   780 WQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLG 831
            ::....|.......|.               |.||:..|.|:||.|...|.|
Zfish   852 YKVVPCGKRVFAVTET---------------LQMGIRHFSGLFVLLCVGVTG 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	80/424 (19%)
		ANF_receptor	53..374	CDD:279440	72/379 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	108/405 (27%)
		Lig_chan	543..816	CDD:278489	68/282 (24%)
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372	84/447 (19%)
grin3bb	XP_017213803.2	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	109/412 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840