Protein Alignment Grik and grin3bb

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_017213803.2
• Gene: grin3bb / 100333101
• ZFINID: ZDB-GENE-131122-77
• Length: 1114
• Species: Danio rerio
• Alignment Length: 962
• Identity: 218/962 - (22%)
• Similarity: 371/962 - (38%)
• Gaps: 224/962 - (23%)

  Fly    11 ASFPLG---FILTSLLLAFPG------CR-----GERTNVG-LVYENTDPDLEKIFHLAISKANE 60
            |.|.||   |:|.:|||..|.      |.     |....:| |:.......:....|.|:|...|
Zfish    10 AYFYLGSQIFLLHTLLLLQPAHSHPQPCHILARIGHTVRLGALLPPRQSVRVRAALHRALSGLAE 74

  Fly    61 ENEDLQLHGVSVSI-----EPGNSFETSKKLCK-MLRQNLVAVFG-PTSNLAARHAMSICDAKEL 118
            ...:...:.:|:.:     :.|:.....:.:|: ::.|.:.||.. |.:.........:....|:
Zfish    75 SGNNFLPYNLSLDVVAREAQSGDPESLFRCVCQDIVVQGVSAVLAFPQTQEEIVQMEFMSSFLEI 139

  Fly   119 PFLDTRWDFGAQLPTINLHPHPATLGV---ALRDMVVAL----GWESFTIIYESGEYLPTVRELL 176
            ||:.. .:.|..|.|.|......|..:   .|.::::|:    |||....:...|.....:.:||
Zfish   140 PFISI-IEHGEPLKTQNRFHLQMTTRIPPSGLVELLLAVLQRSGWEESMAVLCHGWEDAGLLDLL 203

  Fly   177 QMYGTA--GPTVTVRRYELDLNGNYRNVLRRIRNADDF-------------SFVVVGSMATLPE- 225
            ::.|..  ||:....|..|:|:    :...|:.|..||             |.::.|:.   ||
Zfish   204 KLQGRFGWGPSQWHLRAALNLS----HSTARMANISDFLSEHFNLDHSPPASVLLFGAD---PEC 261

  Fly   226 ---FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYES 287
               ..:.|..:||......:|:|:         |             :|||:
Zfish   262 ASSVLRSAHDLGLTLPTVHWIMGH---------P-------------LSPDA------------- 291

  Fly   288 EEPFQNVSCPLTNSMALVY-------------DGVQLL--AETYKHVNFRPVALSCNDDSAWDK- 336
               ..::..||.   .|.|             |.:||:  |.|...|....:||..|..:.:||
Zfish   292 ---LHSIGLPLG---LLAYGEVDHKPLDFYISDALQLINRAVTAATVVRPDLALIQNMVNCFDKP 350

  Fly   337 --------GYTLVNYMKSLTLNGLTGP--IRFDYEGLRTDFKLEVIELAVSGMQK-----IGQWS 386
                    |..:..::.:.:..|||||  ::.:...:.|..|:.:..|....:.:     :|.|.
Zfish   351 NKHELPSSGQYIARFLSNTSFVGLTGPVIVQRNLSRVHTSHKVHIWSLRRDAVGQPTWVTVGSWE 415

  Fly   387 G------EDGFQENRPAPAHSLEPDMR--------------------SLVNKSFVVITAISE--- 422
            |      |.|..:. .:|....|..|.                    :||...||....:.|
Zfish   416 GGRLNVEEQGLWQG-SSPRQRTEGQMGREGRRWRAGFPVSGSRLRVVTLVEHPFVFTREVDEDGN 479

  Fly   423 -PYGML--------KET-----SEKLEGNDQF---------EGFGIELIDELSKKLGFSYTWRLQ 464
             |.|..        .||     :|:.:||..|         .|:.|:|:::||:.:.|.:...:.
Zfish   480 CPAGQYCLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEKLSEDMNFEFDLYIV 544

  Fly   465 EDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKE 529
            .|.|||.:  |.|:|.|::.:::...|||.:|..::.|.|...:|||.||.|..:|||.|.....
Zfish   545 GDGKYGAV--KGGQWTGLVGDLLSGVADMAVTSFSINSARSKVIDFTSPFFSTSLGILVRSKDTA 607

  Fly   530 PPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGR-LSPAEWDNPYPCIEEPTELENQFSFANCL 593
            .| :.:||.|....:|       ||:.:::.:... |:..||.:|:............||:::.|
Zfish   608 AP-IGAFMWPLHWSMW-------MGIFVALHITALFLTLYEWKSPFGMTPHGRNRVKVFSYSSAL 664

  Fly   594 WFSIGALL-QQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESL---VTPINDADD 654
            ......|. :..|...||.::.|.:...|..|.|:::|||||||||.:..|..   |:.|:|| .
Zfish   665 NLCYAILFGRTVSSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDA-K 728

  Fly   655 LSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSN---YAF 716
            |.....|..:|.....:..::.|:|    :..|:|:||   ::...|..:||..::...   .||
Zfish   729 LHHPSQGFRFGTVRESSAEDYMKKS----FPEMHEYMR---KFNEPTTPDGVATLKTDPPQLDAF 786

  Fly   717 LMESTTIEY--ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKW 779
            :|:...::|  ..:..|.|..||.....:||||.:.:|.|....:|:.|...:..|.:..:..||
Zfish   787 IMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNISEFVSRYKSDGYMDMLHDKW 851

  Fly   780 WQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLG 831
            ::....|.......|.               |.||:..|.|:||.|...|.|
Zfish   852 YKVVPCGKRVFAVTET---------------LQMGIRHFSGLFVLLCVGVTG 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	81/430 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	108/405 (27%)
grin3bb	XP_017213803.2	Periplasmic_Binding_Protein_type1	39..427	CDD:471960	82/436 (19%)
		PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	109/412 (26%)
		Lig_chan	618..885	CDD:459656	73/296 (25%)