DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and LOC100149482

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	835	Identity:	176/835 - (21%)
Similarity:	315/835 - (37%)	Gaps:	225/835 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 PATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLR 204
            |.||...|.|::.|...:.  ::||....||.         ..||...:..:.....|
Zfish   103 PRTLLSQLCDLLAARPLQG--LVYEDERPLPL---------ATGPLAPMLEFVSAQTG------- 149

  Fly   205 RIRNADDFSFVVVGSMATL---PE-----FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAG 261
                   ...|.||..|.|   |:     |.:.:....|.......::...||....:...:|.|
Zfish   150 -------LPIVAVGGGAALGRVPQESGSIFLQFSSSTALQLEVIFEVLEEYDWTAFSVVSTRHHG 207

  Fly   262 --------------------------TNITG-----------------LRLVSPDSEQVQEVAKA 283
                                      .|:|.                 :||:....|:.::|..|
Zfish   208 YQDFLSVVEGLTDGSFIGWEKKSIVMLNLTDDPGGVRTQRLLKENEAQVRLLYCSQEEAEQVFLA 272

  Fly   284 LYES-------------------------------------EEPFQNVSCPLTNSMALVYDGVQL 311
            .:.:                                     :||.:.::    ..::::..|...
Zfish   273 AWAAGQAGASHIWFAVGPALSELGLTGLPKRLFAVRPQGWRDEPRRRIA----RGVSILTHGAVA 333

  Fly   312 LAETYKHVNFRPVALSC-NDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELA 375
            |.:.|..........:| .|.:...:....:.|..::||.|  ....|..||...:..|:||...
Zfish   334 LRKDYGATGGPHFVTNCQTDGNRTQRIRGRMRYFSNITLGG--RDYSFSNEGYLANPFLDVISYT 396

  Fly   376 V-SGMQKIGQWSGEDGFQENRPAPAHS-----LEPD-------MRSLVNKSFVVI---------- 417
            . ||.:.:|.|  |:|....| .||.|     |:|.       :.:|..:.||::
Zfish   397 PGSGWEDVGWW--ENGVLRLR-YPAWSRYGPFLQPPDDAQHLRVVTLEERPFVIVELADAASGTC 458

  Fly   418 -------------TAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKY 469
                         :|:.|....:|:..         :||.|:::..|::.:||:|...|..:.|:
Zfish   459 IRDSVPCRRPLNASALQEGVAPVKQCC---------KGFCIDILKRLARIVGFTYDLYLVTNGKH 514

  Fly   470 G-GIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILF-RKPMKEPPK 532
            | .||   |.||||:.|::..||||.|..||:..||...|||::||:..||.::. |......|.
Zfish   515 GKKID---GVWNGMVGEVVYKRADMAIGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 576

  Fly   533 LFSFMSPFSGEVWLWLGLAYMG-VSISMFVLGRLSPAEWDNPYPCIEEPTELE-------NQFSF 589
              :|:.|:|..||:.:.:..:. |::::|:....||..::.         .|:       ::|:.
Zfish   577 --AFLEPYSPAVWVMMFVMCLTVVAVTVFIFEFFSPVGYNR---------SLQSGKKAGGSKFTI 630

  Fly   590 ANCLWFSIGALLQQGSELA--PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDA 652
            ...:|. :.||:...|...  ||..:::.:...|.||.:|.::|||||||||:..|..:..::..
Zfish   631 GKSIWL-LWALVFNNSVPVENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYIDTVSGL 694

  Fly   653 DDL-----SKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGV-DRVEN 711
            .|.     ::....:.:|....|:|....: ||||          |..|||...||:.| |.:.:
Zfish   695 SDKKFQHPTEQYPPLKFGTVPNGSTEKNIR-SNYP----------DMHQYMVKYNQKSVEDAISH 748

  Fly   712 SNY----AFLMESTTIEYIT--ERRCTLTQVGA--LLDEKGYGIAMRKNWPYRDTLSQAVLEMQE 768
            ...    ||:.::..:.|:.  :..|.:..:|:  :....|||||:.||..::..|..|:|::..
Zfish   749 LKTGKLDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGIALIKNSRWKRPLDLALLQLVG 813

  Fly   769 QGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFV 823
            ...:..::..|.     .|.|.:...:..:..|:|.|:.|||.::.|.....:.|
Zfish   814 DDEIEMLERLWL-----SGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	54/340 (16%)
		ANF_receptor	53..374	CDD:279440	49/322 (15%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	104/418 (25%)
		Lig_chan	543..816	CDD:278489	68/296 (23%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	58/351 (17%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	107/437 (24%)
		HisJ	<487..>570	CDD:223904	35/85 (41%)
		Lig_chan	585..857	CDD:278489	69/297 (23%)
		NMDAR2_C	868..>900	CDD:287527
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591294
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840