DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and grin1b

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001137603.1	Gene:	grin1b / 100005675	ZFINID:	ZDB-GENE-051202-2	Length:	937	Species:	Danio rerio

Alignment Length:	1011	Identity:	238/1011 - (23%)
Similarity:	406/1011 - (40%)	Gaps:	218/1011 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTSLLLAFPGCRGERTNVGLVYENTDPDLEKIFHLAISKANE--ENEDLQLHGVSVSIEPGNSFE 81
            |.|...|..||..:..|:|.|.  :....|::|..|:::||.  ..:..:::.:||:.:| |:.:
Zfish     9 LISCSCARGGCEPKTVNIGAVL--SQKRYEQVFKDAVTQANNIYGKDKFKMNAISVTHKP-NAIQ 70

  Fly    82 TSKKLCKMLRQN----LVAVFGPTSN---------------------LAARHAMSICDAKELPFL 121
            .:..:|:.|..|    ::....|.||                     |..|  |||...|.:..
Zfish    71 MALSVCEDLISNQVYAILVSHPPQSNDHLTPTPVSYTAGFYRIPVVGLTTR--MSIYSDKSIHL- 132

  Fly   122 DTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTV 186
                   :.|.|:..:.|.|.:..   ||:....|....:|..........::.|:       |:
Zfish   133 -------SFLRTVPPYSHQAQVWF---DMMREFQWNHIILIVSDDHEGRAAQKRLE-------TL 180

  Fly   187 TVRRYELDLNGNYRNVLRRIRNADDFSF----------VVVGSM-----ATLPE----------- 225
            ...|.....|.||.|:       |..||          |::.|.     |.|.|
Zfish   181 LEERETKSKNRNYENL-------DQLSFDNKRGPKAEKVLLFSQDTNLTALLQEAKELEARVIIL 238

  Fly   226 ---------FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVA 281
                     .:|.|:|:.:..|.|.:::|..:   |..:....|...:.||:|::..:|.
Zfish   239 SASEDEAAAIYKVARQLNMTGSGYVWLVGERE---MSGKALSEAPDGLLGLQLINGKNES----- 295

  Fly   282 KALYESEEPFQNVSCPLTNSMALVYDGVQLLA----ETYKHVNFRPVALSC-NDDSAWDKGYTLV 341
                                 |.:||.|.::|    |.::..|.......| .:.:.|..|....
Zfish   296 ---------------------AHIYDAVAVVAQSIQELFEKENITEPPRGCVGNTNIWKTGPLFK 339

  Fly   342 N-YMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGED---GFQENRPAPAHSL 402
            . .|.|...:||||.:.|:.:|.|......::....:.:.::|.::|..   ..|.....|....
Zfish   340 RVLMSSKYPDGLTGRVEFNDDGDRRFAHYSILNYQKTRLVQVGVYNGSQVVMNAQRKIIWPGGET 404

  Fly   403 EPDMRSLVNKSFVVITAISEPYGMLKET-------------------------SEKLEGNDQFE- 441
            |......::....::|...||:..:|.|                         :|.:.|.....
Zfish   405 EKPKGYQMSTRLKIVTIHQEPFVYVKPTLRDGTCKEEHTVNGVKIKKVICTGPNETIPGRPIVPQ 469

  Fly   442 ---GFGIELIDELSKKLGFSYTWRLQEDNKYGGID----PKTGEWNGMLREIIDSRADMGITDLT 499
               ||.|:|:.:|:..:.|:|...|..|.|:|..:    ....|||||:.|::...|||.:..||
Zfish   470 CCYGFCIDLLIKLAFTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGLADMIVAPLT 534

  Fly   500 MTSERESGVDFTIPFMSLGIGILFRKPMKEPPK--LFSFMSPFSGEVWLWLGLAYMGVSISMFVL 562
            :.:||...::|:.||...|:.||.:   ||.|:  |.|||.||...:||.:||:...|::.:::|
Zfish   535 INNERAQYIEFSKPFKYQGLTILVK---KEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLL 596

  Fly   563 GRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQG-SELAPKAYSTRAVAASWWFFTL 626
            .|.||.....    :....|.|:..:.::.:|||.|.||..| .|.||:::|.|.:...|..|.:
Zfish   597 DRFSPFGRFK----VNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAM 657

  Fly   627 ILVSSYTANLAAFLTV---ESLVTPINDADDLSKNKGGVNYGAKIGGATFNFF----KESNYPTY 684
            |:|:||||||||||.:   |..:|.|||              .::...:..|.    |:|:...|
Zfish   658 IIVASYTANLAAFLVLDRPEERITGIND--------------PRLRNPSDKFIYATVKQSSVDIY 708

  Fly   685 QR-------MYEFMRDNPQYMTNTNQEGVDRV-ENSNYAFLMESTTIEYITERRCTLTQVGALLD 741
            .|       ||..|.   ::...:..|.:..| :|..:||:.:|..:|:...::|.|...|.|..
Zfish   709 FRRQVELSTMYRHME---KHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFF 770

  Fly   742 EKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKW--WQEKRGGGACSDADEDSGAVA-LEI 803
            ..|:||.|||:.|::..:|.|:|...|.|.:..:...|  :||         .|..|.|.| |..
Zfish   771 RSGFGIGMRKDSPWKQNVSLAILSSHENGFMEDLDKTWVRYQE---------CDSRSNAPATLTF 826

  Fly   804 SNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPK 868
            .|:.|||:::..|...|||:..:|:.....:.:...|:......::..|..||...:.:|...||
Zfish   827 ENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPK 891

  Fly   869 NSSRSNASSKSKGSSMSVDSLPEDTS-EADASGKHN 903
            ..:...:.|.:..|::......:||. ..|.:|:.|
Zfish   892 KKASFRSISTNLASNIKRRRSSKDTPYPTDITGQLN 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	79/424 (19%)
		ANF_receptor	53..374	CDD:279440	73/388 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	120/422 (28%)
		Lig_chan	543..816	CDD:278489	85/291 (29%)
grin1b	NP_001137603.1	PBP1_iGluR_NMDA_NR1	5..401	CDD:107374	86/450 (19%)
		ANF_receptor	36..372	CDD:279440	75/392 (19%)
		PBP2_iGluR_NMDA_Nr1	413..815	CDD:270437	122/434 (28%)
		Lig_chan	577..840	CDD:278489	85/292 (29%)
		CaM_bdg_C0	851..879	CDD:287524	2/27 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910