Protein Alignment Ktl and KCTD10

DIOPT Version :10

• Sequence 1: NP_650926.1
• Gene: Ktl / 42475
• FlyBaseID: FBgn0038839
• Length: 228
• Species: Drosophila melanogaster
• Sequence 2: NP_001304324.1
• Gene: KCTD10 / 83892
• HGNCID: 23236
• Length: 314
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 61/319 - (19%)
• Similarity: 94/319 - (29%)
• Gaps: 127/319 - (39%)

  Fly   371 PVTLRRAHLRESLSSHEEAQRLQRMCRELKNKV----------ALSKVLNYAHERTAEELEELEL 425
            |.||            |..:::.....|||.|:          |:::::     ..||||::...
Human   393 PTTL------------ESTEKIVETIEELKVKIPSNPLEADILAMAEMI-----AEAEELDKASS 440

  Fly   426 DRTGTVGSRS------------------------HLSALDEPDLD--------QLDVTLNATSKF 458
            |....|.::|                        ..:.||||..|        .||:..:....|
Human   441 DLCDLVSNQSAEGLLEDCDLFGTARDDVLAMAVKMANVLDEPGQDLEADFPKNPLDINPSVDFLF 505

  Fly   459 TISLTGPDFTMHRCDDPFRKLGPIAIFSARRHWTAPRSVRLQKGGPSFLLGGGTLDRRQSPYGGG 523
            ...|.||:......|                   .||::|  ||....:|.
Human   506 DCGLVGPEDVSTEQD-------------------LPRAMR--KGQKRLMLS-------------- 535

  Fly   524 CANKTNYYNDSRACEVCLKDVCNVSEREFRELKLQDGGGGGGGGEQQQHGTDGTGADDGRGDISS 588
                          |.|.:|..: |:.....|....|........|.::....|    .:||...
Human   536 --------------ESCSRDSLS-SQPSCTGLNYSYGVNAWKCWVQSKYANGET----SKGDELR 581

  Fly   589 FG---FNIRGDAPVMISTVEIN-SLADL--------GGIKEGDFIVELCGVDVKWYTLQ 635
            ||   ..|:.|. :..|..|:| .||..        |...|.|.|..|| :.::.|.|:
Human   582 FGPKPMRIKEDI-LACSAAELNYGLAQFVREITRPNGERYEPDSIYYLC-LGIQQYLLE 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ktl	NP_650926.1	BTB_POZ_KCTD8-like	1..99	CDD:349676
		H1_KCTD12-like	106..227	CDD:409026
KCTD10	NP_001304324.1	BTB_POZ_KCTD10_BACURD3	26..136	CDD:349707
		PCNA-binding. /evidence=ECO:0000250	240..246