DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ktl and Kctd6

DIOPT Version :9

Sequence 1:	NP_001303467.1	Gene:	Ktl / 42475	FlyBaseID:	FBgn0038839	Length:	228	Species:	Drosophila melanogaster
Sequence 2:	NP_001292865.1	Gene:	Kctd6 / 71393	MGIID:	1918643	Length:	237	Species:	Mus musculus

Alignment Length:	105	Identity:	44/105 - (41%)
Similarity:	66/105 - (62%)	Gaps:	1/105 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPEIIELNVGGVSYTTTLATLLQDKSTLLAELFGEGRDSLAKDSKGRYFLDRDGVLFRYILDFLR 65
            |.:.:.|||||..|||:|.||.:...::|..:|| |....|:|.:|.||:||||.||||:|:|||
Mouse    10 MSDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFG-GDFPTARDPQGNYFIDRDGPLFRYVLNFLR 73

  Fly    66 DKALHLPEGFRERQRLLREAEHFKLTAMLECIRSERDARP 105
            ...|.||..|:|...|.:||:.:::..:::|:...|...|
Mouse    74 TSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPRPLYP 113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ktl	NP_001303467.1	BTB	5..97	CDD:197585	40/91 (44%)
Ktl	NP_001303467.1	BTB	5..91	CDD:295341	40/85 (47%)
Kctd6	NP_001292865.1	Interaction with ANK1 isoform Mu7. /evidence=ECO:0000250\|UniProtKB:Q8NC69	1..104		41/94 (44%)
		BTB_POZ	10..113	CDD:365784	43/103 (42%)
		Interaction with CUL3. /evidence=ECO:0000250\|UniProtKB:Q8NC69	10..110		42/100 (42%)
		Interaction with USP21. /evidence=ECO:0000250\|UniProtKB:Q8NC69	113..187		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14499
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X239
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910