DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ktl and kctd12.2

DIOPT Version :9

Sequence 1:	NP_001303467.1	Gene:	Ktl / 42475	FlyBaseID:	FBgn0038839	Length:	228	Species:	Drosophila melanogaster
Sequence 2:	NP_001029191.1	Gene:	kctd12.2 / 553403	ZFINID:	ZDB-GENE-060117-4	Length:	271	Species:	Danio rerio

Alignment Length:	263	Identity:	115/263 - (43%)
Similarity:	158/263 - (60%)	Gaps:	43/263 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EIIELNVGGVSYTTTLATLLQDKSTLLAELFGEGRDS-LAKDSKGRYFLDRDGVLFRYILDFLRD 66
            |||||||||..|.|..:|||...::||..:|.:.:.: |..|||||:||||||.|||||||:|||
Zfish    15 EIIELNVGGQVYVTRHSTLLSVPNSLLWTMFSQKKPAELTTDSKGRFFLDRDGFLFRYILDYLRD 79

  Fly    67 KALHLPEGFRERQRLLREAEHFKLTAMLECIR---------SER--------------------- 101
            :.|.||:.|:|:..||:|||:|:|..:.:.::         ||.
Zfish    80 QTLVLPDYFKEKASLLKEAEYFQLQDLAKRLKPAVSKENSISEEVCQSDPEEAALAGTSMTCTGP 144

  Fly   102 -----DARPPGCITIGYRGSFQFGKDGLADVKFRKLSRILVCGRVAQCREVFGDTLNESRDPDHG 161
                 |||..|.||||||||:..|:|...|.|||:::||.|||:.:..:||||:|||||||||.
Zfish   145 RSPSLDARKTGFITIGYRGSYTIGRDLQQDAKFRRVARITVCGKTSLAKEVFGETLNESRDPDR- 208

  Fly   162 GTDRYTSRFFLKHCYIEQAFDNLHDHGYRMAGSCGSGTAGSAA-EPKPGVDTEENRWNHYNEFVF 225
            ..:|||||::||:.::|||||.|.:.|:.|.....:||...|: :|     .|:..|..|.|:||
Zfish   209 PPERYTSRYYLKYNFLEQAFDRLAEVGFHMVACSSTGTCAYASNDP-----NEDKIWTSYTEYVF 268

  Fly   226 IRD 228
            .|:
Zfish   269 CRE 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ktl	NP_001303467.1	BTB	5..97	CDD:197585	49/92 (53%)
Ktl	NP_001303467.1	BTB	5..91	CDD:295341	48/86 (56%)
kctd12.2	NP_001029191.1	BTB	17..108	CDD:197585	49/90 (54%)
kctd12.2	NP_001029191.1	BTB	17..107	CDD:295341	49/89 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593957
Domainoid	1	1.000	124	1.000	Domainoid score	I5445
eggNOG	1	0.900	-	-		E1_KOG2723
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3746
OMA	1	1.010	-	-		QHG49144
OrthoDB	1	1.010	-	-		D1579292at2759
OrthoFinder	1	1.000	-	-		FOG0001212
OrthoInspector	1	1.000	-	-		otm25414
orthoMCL	1	0.900	-	-		OOG6_106901
Panther	1	1.100	-	-	O	PTHR14499
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2965
SonicParanoid	1	1.000	-	-		X239
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800