DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ktl and KCTD1

DIOPT Version :9

Sequence 1:	NP_001303467.1	Gene:	Ktl / 42475	FlyBaseID:	FBgn0038839	Length:	228	Species:	Drosophila melanogaster
Sequence 2:	NP_001136202.1	Gene:	KCTD1 / 284252	HGNCID:	18249	Length:	865	Species:	Homo sapiens

Alignment Length:	238	Identity:	73/238 - (30%)
Similarity:	118/238 - (49%)	Gaps:	45/238 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IELNVGGVSYTTTLATLLQDKSTLLAELFGEGRDSLAKDS-KGRYFLDRDGVLFRYILDFLRDKA 68
            :.::|||..||::||||.:...:.:..|| :|.:.:..|| |..||:||||.:|||||:|||...
Human   640 VHIDVGGHMYTSSLATLTKYPESRIGRLF-DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSK 703

  Fly    69 LHLPEGFRERQRLLREAEHFKLTAM-LECIRSERD------ARPPGCITIGYRGSFQFGKDGLAD 126
            |.:|:.|::...|..||::|:|..| ||..|.::|      :||..|:.:  |.:...|:
Human   704 LLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETGRFSRPCECLVV--RVAPDLGE----- 761

  Fly   127 VKFRKLSRILVCGRVAQCREVF---GDTLNESRDPDHGGTDRYTSRFFLK-HCYIE--QAFDNLH 185
                   ||.:.|..:...|||   ||.:..|.:........:..||.|. :|::.  |..:.|.
Human   762 -------RITLSGDKSLIEEVFPEIGDVMCNSVNAGWNHDSTHVIRFPLNGYCHLNSVQVLERLQ 819

  Fly   186 DHGYRMAGSCGSGTAGSAAEPKPGVDTEENRWNHYNEFVFIRD 228
            ..|:.:.||||.           |||:.:     ::|:|..|:
Human   820 QRGFEIVGSCGG-----------GVDSSQ-----FSEYVLRRE 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ktl	NP_001303467.1	BTB	5..97	CDD:197585	40/93 (43%)
Ktl	NP_001303467.1	BTB	5..91	CDD:295341	36/86 (42%)
KCTD1	NP_001136202.1	DUF3504	284..439	CDD:288835
		BTB	640..735	CDD:197585	40/95 (42%)
		BTB	640..732	CDD:295341	39/92 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810