DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ktl and Kctd8

DIOPT Version :9

Sequence 1:	NP_001303467.1	Gene:	Ktl / 42475	FlyBaseID:	FBgn0038839	Length:	228	Species:	Drosophila melanogaster
Sequence 2:	NP_780728.3	Gene:	Kctd8 / 243043	MGIID:	2443804	Length:	476	Species:	Mus musculus

Alignment Length:	288	Identity:	116/288 - (40%)
Similarity:	158/288 - (54%)	Gaps:	68/288 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PEIIELNVGGVSYTTTLATLLQDKSTLLAELFGEG--------RDSLAKDSKGRYFLDRDGVLFR 58
            ||::||||||..|.|..:|||....:.||.:|...        |..|.:||:.|:|:||||.|||
Mouse    43 PEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGGARRRGDLPRDSRARFFIDRDGFLFR 107

  Fly    59 YILDFLRDKALHLPEGFRERQRLLREAEHFKLTAML---------------ECIRSE-------- 100
            |:||:||||.|.|||.|.|::|||||||.|:||.::               ||.:|:
Mouse   108 YVLDYLRDKQLALPEHFPEKERLLREAEFFQLTDLVKLLSPKVTKQNSLNDECCQSDLEDNVSQG 172

  Fly   101 -RDA------------------------------RPPGCITIGYRGSFQFGKDGLADVKFRKLSR 134
             .||                              :..|.:|:|||||:...:|..||.|||:::|
Mouse   173 SSDALLLRGAAAGAPSGSGAHGVSGVVGGGSAPDKRSGFLTLGYRGSYTTVRDNQADAKFRRVAR 237

  Fly   135 ILVCGRVAQCREVFGDTLNESRDPDHGGTDRYTSRFFLKHCYIEQAFDNLHDHGYRMAGSCGSGT 199
            |:||||:|..:||||||||||||||. ..::|||||:||..|:|||||.|.:.|:.|.....|||
Mouse   238 IMVCGRIALAKEVFGDTLNESRDPDR-QPEKYTSRFYLKFTYLEQAFDRLSEAGFHMVACNSSGT 301

  Fly   200 AGSAAEPKPGVDTEENRWNHYNEFVFIR 227
            |....:.:     ::..|:.|.|::|.|
Mouse   302 AAFVNQYR-----DDKIWSSYTEYIFFR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ktl	NP_001303467.1	BTB	5..97	CDD:197585	51/114 (45%)
Ktl	NP_001303467.1	BTB	5..91	CDD:295341	48/93 (52%)
Kctd8	NP_780728.3	BTB	46..145	CDD:197585	50/98 (51%)
		BTB	46..142	CDD:295341	50/95 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5438
eggNOG	1	0.900	-	-		E1_KOG2723
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18464
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3509
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001212
OrthoInspector	1	1.000	-	-		otm43437
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14499
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2965
SonicParanoid	1	1.000	-	-		X239
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.950