DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ktl and KCTD2

DIOPT Version :10

Sequence 1:NP_650926.1 Gene:Ktl / 42475 FlyBaseID:FBgn0038839 Length:228 Species:Drosophila melanogaster
Sequence 2:NP_056168.1 Gene:KCTD2 / 23510 HGNCID:21294 Length:263 Species:Homo sapiens


Alignment Length:222 Identity:51/222 - (22%)
Similarity:81/222 - (36%) Gaps:67/222 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 IELNVGGVSYTTTLATLLQDKSTLLAELFGEGRDSL--AKDSKGRYFLDRDGVLFRYILDFLRDK 67
            :.|||||..:.||..||.::..:.|..|..:....|  .||..|.|.:|||...|..||::||..
Human    74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHG 138

  Fly    68 ALHLPEGFRERQRLLREAEHFKLTAML----ECIRSERDARPPGCITIGYRGSFQFGKDGLADVK 128
            .|.:.:...| :.:|.|||.:.:.:::    |.||...:....|.:...|               
Human   139 KLIITKELAE-EGVLEEAEFYNIASLVRLVKERIRDNENRTSQGPVKHVY--------------- 187

  Fly   129 FRKLSRILVCGRVAQCRE--------------VFGDTLNESRDPDHGGTDRYTSRFFLKHCYIEQ 179
                       ||.||:|              .|...::.....::|..|:..   ||  |.:.:
Human   188 -----------RVLQCQEEELTQMVSTMSDGWKFEQLISIGSSYNYGNEDQAE---FL--CVVSR 236

  Fly   180 AFDN---------------LHDHGYRM 191
            ..:|               |.:.|.||
Human   237 ELNNSTNGIVIEPSEKAKILQERGSRM 263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KtlNP_650926.1 BTB_POZ_KCTD8-like 1..99 CDD:349676 32/99 (32%)
H1_KCTD12-like 106..227 CDD:409026 18/115 (16%)
KCTD2NP_056168.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..69
BTB_POZ_KCTD2 72..177 CDD:349697 33/103 (32%)
Blue background indicates that the domain is not in the aligned region.

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