DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ktl and KCTD7

DIOPT Version :9

Sequence 1:	NP_001303467.1	Gene:	Ktl / 42475	FlyBaseID:	FBgn0038839	Length:	228	Species:	Drosophila melanogaster
Sequence 2:	NP_694578.1	Gene:	KCTD7 / 154881	HGNCID:	21957	Length:	289	Species:	Homo sapiens

Alignment Length:	260	Identity:	68/260 - (26%)
Similarity:	110/260 - (42%)	Gaps:	75/260 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PEIIELNVGGVSYTTTLATLLQDKSTLLAELFGEGRDSLAKDSKGRYFLDRDGVLFRYILDFLRD 66
            ||::.||:||..:||.|:||...:.|:||.:| .||..:..||:||||:||||..|..:|:|||.
Human    50 PEVVPLNIGGAHFTTRLSTLRCYEDTMLAAMF-SGRHYIPTDSEGRYFIDRDGTHFGDVLNFLRS 113

  Fly    67 KALHLPEGFRERQR-LLREAEHFKLTAMLECIRSERDARPPGCITIGYRGSFQFGKDGLADV--- 127
            .  .||.  |||.| :.:||:::.:..:||.:.:.:..:... :...:.|...:.||.|..:
Human   114 G--DLPP--RERVRAVYKEAQYYAIGPLLEQLENMQPLKGEK-VRQAFLGLMPYYKDHLERIVEI 173

  Fly   128 -KFRKLSRILVCGRVAQCREVFGD-------------TLNESRDPDHGGTDRYTSRFFLKHCYIE 178
             :.|.:.|.....::..|  ||.:             :|...|....|       :.|..||.::
Human   174 ARLRAVQRKARFAKLKVC--VFKEEMPITPYECPLLNSLRFERSESDG-------QLFEHHCEVD 229

  Fly   179 QAF----------DNLH-------------DHGYRMAGSCGSGTAGSAAEPKPGVDTEENRWNHY 220
            .:|          |.||             ||  :..|.|                 :::..|||
Human   230 VSFGPWEAVADVYDLLHCLVTDLSAQGLTVDH--QCIGVC-----------------DKHLVNHY 275

Fly 221 220
Human 276 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ktl	NP_001303467.1	BTB	5..97	CDD:197585	40/92 (43%)
Ktl	NP_001303467.1	BTB	5..91	CDD:295341	38/86 (44%)
KCTD7	NP_694578.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
KCTD7	NP_694578.1	BTB_POZ_KCTD7	48..139	CDD:349675	40/93 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14499
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010