Protein Alignment Ktl and KCTD12

DIOPT Version :10

• Sequence 1: NP_650926.1
• Gene: Ktl / 42475
• FlyBaseID: FBgn0038839
• Length: 228
• Species: Drosophila melanogaster
• Sequence 2: NP_612453.1
• Gene: KCTD12 / 115207
• HGNCID: 14678
• Length: 325
• Species: Homo sapiens
• Alignment Length: 297
• Identity: 114/297 - (38%)
• Similarity: 154/297 - (51%)
• Gaps: 74/297 - (24%)

  Fly     2 PEIIELNVGGVSYTTTLATLLQDKSTLLAELFGEGR-DSLAKDSKGRYFLDRDGVLFRYILDFLR 65
            |:|:||||||..|.|...|::....:||..:|.:.: ..||:|||||:||||||.|||||||:||
Human    33 PDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLR 97

  Fly    66 DKALHLPEGFRERQRLLREAEHFKLTAMLECIRS------------------------------- 99
            |..|.||:.|.||.||.||||:|:|..::..:.:
Human    98 DLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPSRRGVHKEGSLGDELLPLGYS 162

  Fly   100 -----------------ERDARPP---------------------GCITIGYRGSFQFGKDGLAD 126
                             |..:|.|                     |.||||||||:..|:|..||
Human   163 EPEQQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQAD 227

  Fly   127 VKFRKLSRILVCGRVAQCREVFGDTLNESRDPDHGGTDRYTSRFFLKHCYIEQAFDNLHDHGYRM 191
            .|||:::||.|||:.:..:||||||||||||||. ..:|||||::||..::|||||.|.:.|:.|
Human   228 AKFRRVARITVCGKTSLAKEVFGDTLNESRDPDR-PPERYTSRYYLKFNFLEQAFDKLSESGFHM 291

  Fly   192 AGSCGSGTAGSAAEPKPGVDTEENRWNHYNEFVFIRD 228
            .....:||...|:...   .:|:..|..|.|:||.|:
Human   292 VACSSTGTCAFASSTD---QSEDKIWTSYTEYVFCRE 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ktl	NP_650926.1	BTB_POZ_KCTD8-like	1..99	CDD:349676	51/97 (53%)
		H1_KCTD12-like	106..227	CDD:409026	60/141 (43%)
KCTD12	NP_612453.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		BTB_POZ	32..131	CDD:453885	51/97 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	129..202		3/72 (4%)
		H1_KCTD12	206..325	CDD:409028	59/122 (48%)