DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and GLR3.4

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001030971.1	Gene:	GLR3.4 / 839268	AraportID:	AT1G05200	Length:	959	Species:	Arabidopsis thaliana

Alignment Length:	920	Identity:	210/920 - (22%)
Similarity:	368/920 - (40%)	Gaps:	195/920 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RKAQSLPDIIKIGGLF----------HPADDHQELAFRQAVDRINADRSILPRSKL--VAQIERI 73
            |..:..|..:.:|.||          .|       |.:.|:|.:|||:|:|...||  :.|....
plant    52 RPLRQRPSSVNVGALFTYDSFIGRAAKP-------AVKAAMDDVNADQSVLKGIKLNIIFQDSNC 109

  Fly    74 SPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL----------ENRWDYRL 128
            |.|.......:   |:...|.|..|||||..|..:..:.:.:.:|.|          ..::.|.|
plant   110 SGFIGTMGALQ---LMENKVVAAIGPQSSGIAHMISYVANELHVPLLSFGATDPTLSSLQFPYFL 171

  Fly   129 RRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENND----GIVRLQELL-KAHGMTPFPIT 188
            |...   |.|...:    |..|.:.:.||:....|:.:::    ||..|.::| |......:...
plant   172 RTTQ---NDYFQMH----AIADFLSYSGWRQVIAIFVDDECGRNGISVLGDVLAKKRSRISYKAA 229

  Fly   189 VRQLSDSGDYRPLLKQIKNSAEAHI-VLDCSTERIHEVLKQAQQIGMMSDYHSYLVTS------- 245
            :...:||...|.||..: |..|:.: |:..:.:....|...|:.:|||:..:.::.|.
plant   230 ITPGADSSSIRDLLVSV-NLMESRVFVVHVNPDSGLNVFSVAKSLGMMASGYVWIATDWLPTAMD 293

  Fly   246 ----LDLHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYD 306
                :|..|::|.:      .:..||  :..|.|.|.||:....|.|..:...   .|.....||
plant   294 SMEHVDSDTMDLLQ------GVVAFR--HYTIESSVKRQFMARWKNLRPNDGF---NSYAMYAYD 347

  Fly   307 AVHLFAKAL-------HDLDTSQQIDIHPISCDGQSTWQHGFSLIN----YMKIV---EMKGLTN 357
            :|.|.|:||       :::..|...::|  ..:|.:......|:.|    :|||:   ...|:|.
plant   348 SVWLVARALDVFFRENNNITFSNDPNLH--KTNGSTIQLSALSVFNEGEKFMKIILGMNHTGVTG 410

  Fly   358 VIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDGINFTR---TFSQKQQEIEANLKNKTLV 419
            .|:||....|.:...:::.|.....|.:|.|::  ..|::...   .:|:......||.:.|.::
plant   411 PIQFDSDRNRVNPAYEVLNLEGTAPRTVGYWSN--HSGLSVVHPETLYSRPPNTSTANQRLKGII 473

  Fly   420 VTTILSNPYCMRKESAIPLSG------------------NDQ----FEGYAVDLIHEISKSLGFN 462
            ....::.|   .:....|.:|                  .|:    ..||.:|:         |.
plant   474 YPGEVTKP---PRGWVFPNNGKPLRIGVPNRVSYTDYVSKDKNPPGVRGYCIDV---------FE 526

  Fly   463 YKIQLVP-----------DGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTT 516
            ..|:|:|           ||      |....::.::.|::....|:|:.|:||...|.:.||||.
plant   527 AAIELLPYPVPRTYILYGDG------KRNPSYDNLVNEVVADNFDVAVGDITIVTNRTRYVDFTQ 585

  Fly   517 PFMNLGVSILYRKPIKQPPNL-FSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDA 580
            ||:..|:.::  .|:|:..:. :|||.|.::::|......:|.|..:::||.
plant   586 PFIESGLVVV--APVKEAKSSPWSFLKPFTIEMWAVTGGFFLFVGAMVWILE------------- 635

  Fly   581 HGEKVESQF------TLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLA 639
              .:...:|      .|:...||:..::.....:....:|. |.|..||.|..||:.|||||:|.
plant   636 --HRFNQEFRGPPRRQLITIFWFSFSTMFFSHRENTVSSLG-RFVLIIWLFVVLIINSSYTASLT 697

  Fly   640 AFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFME-SARPSVFTAS 703
            :.||:.::.|.||..:.|..... ..|...|             |:.|.:...| :..||.....
plant   698 SILTIRQLTSRIEGIDSLVTSNE-PIGVQDG-------------TFARNYLINELNILPSRIVPL 748

  Fly   704 NGE-----GVERVAKGKGSYAFLMESTSIE-YVTERNCELTQVGGMLDTKSYGIATPPNSPYRTA 762
            ..|     .::|.....|..|.:.|...|| .:|..||:...||.......:|.|...:||....
plant   749 KDEEQYLSALQRGPNAGGVAAIVDELPYIEVLLTNSNCKFRTVGQEFTRTGWGFAFQRDSPLAVD 813

  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827
            :::.||:|.|||:|..:..||...|.   :|.::.|.|..  ::|.|.:..|:|::    .|:.|
plant   814 MSTAILQLSEEGELEKIHRKWLNYKH---ECSMQISNSED--SQLSLKSFWGLFLI----CGITC 869

  Fly   828 VIAVCEFVWK 837
            .:|:..|.|:
plant   870 FMALTVFFWR 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	96/418 (23%)
		ANF_receptor	42..378	CDD:279440	87/378 (23%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	96/416 (23%)
		Lig_chan	547..823	CDD:278489	69/288 (24%)
GLR3.4	NP_001030971.1	PBP1_GABAb_receptor_plant	62..450	CDD:380645	96/420 (23%)
		Periplasmic_Binding_Protein_Type_2	<518..591	CDD:389745	23/87 (26%)
		Lig_chan	615..869	CDD:365843	70/292 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830