DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and GLR1.3

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_199652.1	Gene:	GLR1.3 / 834896	AraportID:	AT5G48410	Length:	860	Species:	Arabidopsis thaliana

Alignment Length:	819	Identity:	169/819 - (20%)
Similarity:	324/819 - (39%)	Gaps:	199/819 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 GVAAIFGPQSSHTASHVQSICDNMEIP--HLENRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRH 154
            ||.||.|..|...|..:..:.:...:|  .|::.:...|.:.:.|:.......:.:|.....:..
plant   106 GVEAIIGGNSLLEAKLLGELGEKARVPMISLDSPFSLSLSKYTHLIQATHDSTSEAKGITSFINV 170

  Fly   155 WGWKTFTIIYENNDGIVRLQELLKAH------------GMTPFPITVRQLSDSGDY-RPLLKQIK 206
            :.|.:..::||::|......:||..|            |.|        :|.|.|: ...|:|:|
plant   171 FDWNSVALVYEDHDDWRESMQLLVEHFHENGVRVQSKVGFT--------VSSSEDFVMGRLQQLK 227

  Fly   207 NSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTV--NLDEF-RYGGTNITGFR- 267
            :......|:..|......:...|:::|:|.|...:::|:..:::.  |:|:| :.....:.||:
plant   228 DLGTTVFVVHLSEVIATHLFPCARRLGLMGDGFVWILTAKTMNSFHENIDDFTKQAMEGVVGFKS 292

  Fly   268 LINEKI-VSDVVRQWSIDEKGL-LRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPIS 330
            .|...| :.:...:|   .|.| :..|.||.                                :|
plant   293 YIPMSIELQNFTLRW---RKSLPVEEAELTR--------------------------------LS 322

  Fly   331 CDGQSTWQH--GFSLINYMKIVEMKGLTN-----VIKFDHQGFRTDFML----------DIVELT 378
            ..|  .|.|  .|:|....:::.|..:|:     :.|....|...||.|          :|:.:.
plant   323 ISG--IWAHDIAFALARAAEVIRMPNVTSTLLEEITKTRFNGLSGDFQLNDKKLLSNKFEIINMI 385

  Fly   379 PAGIRKIGTWNSTLPDGINFTRTFSQKQQEIE-------------------ANLKNKTLVVTTIL 424
            .:..|::|..||.  ...:..|..|....::|                   ::.|...::||:..
plant   386 GSSERRVGFLNSN--GSFSNRRHLSSTHNKLETIIWPGGSAQSPKGTSLIDSDRKKLRVLVTSSN 448

  Fly   425 SNPYCMRKESAIPLSGNDQFEGYAVDLIH-EISKSLGFNYKIQLVP--DGSYGSLNKLTGEWNGM 486
            ..|..|:.|:. |::.....||:.:::.. .||.   |||:::.:|  :||         .::.:
plant   449 RFPRLMKVETD-PVTNELIVEGFCIEVFRASISP---FNYEVEYIPWLNGS---------NYDNL 500

  Fly   487 IRELLEQ--RADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVW 549
            ...|..|  :.|.|:.|:|||..|...||||.||..:|:.|:   .:|: .:::.|..||:.|:|
plant   501 AYALHSQKDKYDAAVGDITITSNRSTYVDFTLPFTEMGLGIV---AVKE-RSMWVFFQPLTPDLW 561

  Fly   550 IYMATAYLGVSVLLFILAKFTPYE----WPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFL 610
            |..|..::...|:::::.:....|    ||           .|..::  :||...:|:....:.|
plant   562 ITSAFFFVLTGVIVWLIERAENKEFQGSWP-----------QQIGVV--LWFGFSTLVYAHREKL 613

  Fly   611 PKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAED--------LAKQTRIKYGA 667
            ...|| |.|..:|.|..||:.:||||.|.:.:||:::  ...|.||        |.....:...:
plant   614 KHNLS-RFVVTVWVFAVLILTASYTATLTSMMTVQQI--RFNSNEDYVGHLSGSLIANVALTSSS 675

  Fly   668 LK-----GGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSI 727
            |:     |.::||.:..:.::   :..||:....|.:          :|..|:....|.|..|.
plant   676 LRAMRSLGLNSAADYAQALLN---KTVSFVVDELPYL----------KVVLGENPTHFFMVKTQ- 726

  Fly   728 EYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGK 792
                    ..|...|.:..|.:.:.  ||      ::..|.||:...||:.::.:|:..:.
plant   727 --------STTNGFGFMFQKGFELV--PN------VSREISKLRTSEKLNEMEKRWFDNQL---- 771

  Fly   793 CRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAV 831
                ...:...:|.:.|....|:|:::  |:..|..:||
plant   772 ----PYTTDDTSNPITLYRFRGLFIII--GVSFAFALAV 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	65/342 (19%)
		ANF_receptor	42..378	CDD:279440	61/323 (19%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	92/391 (24%)
		Lig_chan	547..823	CDD:278489	59/292 (20%)
GLR1.3	NP_199652.1	PBP1_GABAb_receptor	43..405	CDD:107361	65/345 (19%)
		ANF_receptor	57..385	CDD:279440	61/323 (19%)
		GluR_Plant	438..767	CDD:270404	92/391 (24%)
		Lig_chan	559..798	CDD:278489	60/294 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.880