DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and GLR1.4

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	855	Identity:	180/855 - (21%)
Similarity:	346/855 - (40%)	Gaps:	184/855 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VAQIERISPFDSFHAGKRVCGLLNI-GVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRR 130
            |:.:.|.|..|...|......||.. .|.|:.|.||...|.::..:.:..::|
plant    84 VSVLSRDSHGDPLQALAAAMDLLQTEQVEALVGGQSLLEAKNLAELGEKTKVP------------ 136

  Fly   131 ESCLVNLYPHPNTLS------------------KAYVDIVRHWGWKTFTIIYENNDG-IVRLQEL 176
               :::.:..|::||                  |....:..::.|:|..:|||::|. ...:|.|
plant   137 ---VISSFQVPSSLSLAKYNYFIQATHDTSSEAKGIAALFSNFDWRTAVLIYEDDDDWRESIQPL 198

  Fly   177 LKAHGMTPFPITVR-QLSDSGDYRPLLKQIKNSAE-------AHIVLDCSTERI-HEVLKQAQQI 232
            :.........|..: :.|.|.:...::||::....       |||     :||| :.:...|:::
plant   199 VGHFQQNAIHIEYKAEFSVSSNEECIMKQLRKFKASGIRIFVAHI-----SERIANRLFPCARRL 258

  Fly   233 GMMSDYHSYLVTSLDLHTVNLDEFRYGG----TNITGFRL---INEKIVSDVVRQWSIDEKGLLR 290
            |||.:.:::::|:..::  |..:..|..    ..:.||:.   :.|::.:..:| |    |..||
plant   259 GMMEEGYAWILTARSMN--NFQDTNYLAKEEMEGVIGFKSYIPLTEELHNFTLR-W----KRSLR 316

  Fly   291 SANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIV----E 351
            ...:.|..|..::.          .||:..|       ::...:.....|.|:.:.::.:    :
plant   317 LEEVVTRMSVCSIW----------AHDIAWS-------LARAAEVAKLPGLSVYDLLEAIPESAK 364

  Fly   352 MKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNS------------------TL--PDG- 395
            .|||:..|||..:.|.:| ..:||.:...|.|.:|.|||                  |:  |.|
plant   365 HKGLSGDIKFIDKKFISD-KFEIVNMIGRGERSVGLWNSGSFISNRRRRLSSTKALETIIWPGGS 428

  Fly   396 --INFTRTFSQKQQEIEANLKNKTLVVTTILSN--PYCMRKESAIPLSGNDQFEGYAVDLIHEIS 456
              |...|:..:|:..     |.|.|.|.....|  |..:..::... :|.....||.:|:..  :
plant   429 TRIPKIRSLKEKRHG-----KKKKLRVLVPAGNITPQILEVKTDFK-TGVTAATGYCIDVFE--T 485

  Fly   457 KSLGFNYKIQLVP-DGSYGSLNKLTGEWNGMIRELLEQ--RADLAIADLTITFEREQAVDFTTPF 518
            ..|.|||:::.:| .|:....|     :|.::..|..|  :.|.|:.|:|||..|...||||.||
plant   486 SILPFNYEVEYIPWPGAINYKN-----YNDLVYTLYSQKDKYDAAVGDITITDNRSLYVDFTLPF 545

  Fly   519 MNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGE 583
            .::|::::..|    ..:::....||:|.:|:.:|:.::....:::::.:..      ..|..|.
plant   546 TDMGLAVVTAK----DKSMWIIFKPLTLSLWLTIASFFILTGAIVWLIERHD------NADFQGS 600

  Fly   584 KVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMD 648
            ..:...||| |  |...:|:....:.|...:| |.|..:|.|..||:.|:|||.|.:.:||:::
plant   601 CFQQIGTLL-C--FGFSTLVFAHRERLQHNMS-RFVVIVWIFAVLILTSNYTATLTSVMTVQQI- 660

  Fly   649 SPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERV-- 711
                             ..||......||..|..:.       :.:..|: |.....:|::..
plant   661 -----------------RGLKSNENIGFFSASIAAN-------VVNDNPT-FQGPRYKGLKTADD 700

  Fly   712 ---AKGKGSYAFLMESTSIE--YVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQ 771
               |...|:.:|:::.....  :|.:...|...|.....|..:|.|....||....::..|.||:
plant   701 FTNALRNGTISFIVDEVPYVKLFVAKHPSEFVIVETESVTNGFGFAFQKGSPLVQKVSREIEKLR 765

  Fly   772 EEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVW 836
            ...||..:: .||.::      :..::.|....:.|.:....|:|::.  |:..|..:.|....|
plant   766 RTEKLKAIE-NWWFQR------QTTSATSEDTFHPLTVYTFRGLFMIT--GVSFAFALIVYLIPW 821

  Fly   837 --KSRKVAVE 844
              :.|:|.::
plant   822 NREQRQVVLK 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	78/392 (20%)
		ANF_receptor	42..378	CDD:279440	69/350 (20%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	87/381 (23%)
		Lig_chan	547..823	CDD:278489	55/282 (20%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	75/370 (20%)
		ANF_receptor	64..390	CDD:279440	69/350 (20%)
		GluR_Plant	448..778	CDD:270404	86/378 (23%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	54/201 (27%)
		Lig_chan	570..810	CDD:278489	56/284 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.870