DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and GLR1.1

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_187061.1	Gene:	GLR1.1 / 819566	AraportID:	AT3G04110	Length:	808	Species:	Arabidopsis thaliana

Alignment Length:	895	Identity:	177/895 - (19%)
Similarity:	352/895 - (39%)	Gaps:	213/895 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PADD--HQELAFRQAVDRINADRSILPRS----------------KLVAQIERISPFDSFHAGKR 84
            |:||  .:|:.....||..:....||..|                ..|:.:.|.|..|...|...
plant    21 PSDDDVFEEVRVGLVVDLSSIQGKILETSFNLALSDFYGINNGYRTRVSVLVRDSQGDPIIALAA 85

  Fly    85 VCGLL-NIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESCLVNLYPHPNTLS--- 145
            ...|| |....||.|.||...|..:.:|.:..::|               :::.: .|||||
plant    86 ATDLLKNAKAEAIVGAQSLQEAKLLATISEKAKVP---------------VISTF-LPNTLSLKK 134

  Fly   146 ---------------KAYVDIVRHWGWKTFTIIYENND----GIVRLQELLKAHGMTPFPITVRQ 191
                           |....:::.:..|:..:|||:.|    .:..|.|..:..|:.........
plant   135 YDNFIQWTHDTTSEAKGITSLIQDFSCKSVVVIYEDADDWSESLQILVENFQDKGIYIARSASFA 199

  Fly   192 LSDSGDYRPL--LKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVN-L 253
            :|.||:...:  |:::|.|..:..|:..|...:..:.:..:::|:|.:..::::|:   .|:| |
plant   200 VSSSGENHMMNQLRKLKVSRASVFVVHMSEILVSRLFQCVEKLGLMEEAFAWILTA---RTMNYL 261

  Fly   254 DEFRYGGT--NITGFRL---INEKI--VSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLF 311
            :.|....:  .:.||:.   ::|::  .:..:|:...|:.....|:.:..:|:     :|...:.
plant   262 EHFAITRSMQGVIGFKSYIPVSEEVKNFTSRLRKRMGDDTETEHSSVIIGLRA-----HDIACIL 321

  Fly   312 AKALHDLDTSQQIDIHP-ISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIV 375
            |.|:.....|.:::... :|.|...|.:|.          ..|||:..|:.....|.:: ..:||
plant   322 ANAVEKFSVSGKVEASSNVSADLLDTIRHS----------RFKGLSGDIQISDNKFISE-TFEIV 375

  Fly   376 ELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQEI----------------EANLKNKTLVVTTIL 424
            .:.....|:||.|:.         .:|||::|.:                :...|...::||...
plant   376 NIGREKQRRIGLWSG---------GSFSQRRQIVWPGRSRKIPRHRVLAEKGEKKVLRVLVTAGN 431

  Fly   425 SNPY--CMRKESAIPLSGNDQFEGYAVDLIHEISKS--LGFNYKIQLVPDGSYGSLNKLTGEWNG 485
            ..|:  .:|.:   |.:|.:...|:.|    |:.|:  ..|||:::.:|         ..|..:.
plant   432 KVPHLVSVRPD---PETGVNTVSGFCV----EVFKTCIAPFNYELEFIP---------YRGNNDN 480

  Fly   486 MIRELLEQR--ADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDV 548
            :...|..||  .|.|:.|:|||..|...||||.|:.::|:.||..|  |:...:::|..|....:
plant   481 LAYLLSTQRDKYDAAVGDITITSNRSLYVDFTLPYTDIGIGILTVK--KKSQGMWTFFDPFEKSL 543

  Fly   549 WIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKA 613
            |:.....::...::::::.:...   |.:..:.|:::...      :||...:::....:.|.|
plant   544 WLASGAFFVLTGIVVWLVERSVN---PEFQGSWGQQLSMM------LWFGFSTIVFAHREKLQK- 598

  Fly   614 LSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFR 678
            :|:|.:..:|.|..||:.|||:|||.:..|:.||              ::.:..:.||||.:
plant   599 MSSRFLVIVWVFVVLILTSSYSANLTSTKTISRM--------------QLNHQMVFGGSTTS--- 646

  Fly   679 DSKISTYQRMWSFMESARPSVFTASNG--EGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVG 741
                                 .||..|  ..||       :||.|:...::.:|......|:.:.
plant   647 ---------------------MTAKLGSINAVE-------AYAQLLRDGTLNHVINEIPYLSILI 683

  Fly   742 G-----------MLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKE-----KRGG 790
            |           :.:|..:|......|.....::..|.||:..|.|..::.||:::     ....
plant   684 GNYPNDFVMTDRVTNTNGFGFMFQKGSDLVPKVSREIAKLRSLGMLKDMEKKWFQKLDSLNVHSN 748

  Fly   791 GKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRK 840
            .:....|:....|:.......:.|:|::    .|.|.|:.:...::.:|:
plant   749 TEEVASTNDDDEASKRFTFRELRGLFII----AGAAHVLVLALHLFHTRQ 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	80/410 (20%)
		ANF_receptor	42..378	CDD:279440	73/385 (19%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	84/388 (22%)
		Lig_chan	547..823	CDD:278489	51/293 (17%)
GLR1.1	NP_187061.1	PBP1_GABAb_receptor	31..397	CDD:107361	79/409 (19%)
		ANF_receptor	45..377	CDD:279440	70/366 (19%)
		Periplasmic_Binding_Protein_Type_2	421..737	CDD:304360	84/388 (22%)
		Lig_chan	542..781	CDD:278489	52/297 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.880