DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and GLR5

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_565744.1	Gene:	GLR5 / 817801	AraportID:	AT2G32400	Length:	921	Species:	Arabidopsis thaliana

Alignment Length:	962	Identity:	202/962 - (20%)
Similarity:	363/962 - (37%)	Gaps:	222/962 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSGVLVLPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDH-----QELAFRQAVDRINADRSILP 62
            |..:..|.:::|.:.::|::    |.::.||.:|  |.|.     .::|...||..:|.|:|.|.
plant     8 SVAITALIVVILVVPMDCQR----PQLVNIGAVF--AFDSVIGRAAKVALEAAVSDVNNDKSFLK 66

  Fly    63 RSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYR 127
            .::|...:|. |..:.|........||...|.|:.||.||..|..:..|...:..|
plant    67 ETELRLLMED-SACNVFRGSFGAFELLEKEVVAMIGPISSSVAHTISDIAKGLHFP--------- 121

  Fly   128 LRRESCLVNLYPHPNTLS------------------KAYVDIVRHWGWKTFTIIYENND----GI 170
                  ||:......|||                  .|.||::..:|||....:|.:::    |:
plant   122 ------LVSFAATDPTLSALQFPFFLRTTPNDAHQMSALVDLINFYGWKEVISVYSDDELGRNGV 180

  Fly   171 VRL-QELLKAHGMTPFPITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGM 234
            ..| .||.|......:.:.:...||.......|.:.|:......:|....:.:..:...||::.|
plant   181 SALDDELYKKRSRISYKVPLSVHSDEKFLTNALNKSKSIGPRVYILHFGPDPLLRIFDIAQKLQM 245

  Fly   235 MSDYHSYLVTSLDLHTVNLDEFRYGGT-----NITGFRLINEKIVSDVVRQWSIDEKGLLRSANL 294
            |:  |.|:..:.|..:|.||.....||     .:.|.|   :.|...|..:....:....||.|.
plant   246 MT--HEYVWLATDWLSVTLDSLSDKGTLKRLEGVVGLR---QHIPESVKMEHFTHKLQSNRSMNA 305

  Fly   295 TTVRSETALMYDAVHLFAKALHDL---------DTSQQIDIHPISCDGQSTWQH---------GF 341
            ..:.:     ||.|.:.|..:.:|         ..|::: :|     .:.|..|         |.
plant   306 YALHA-----YDTVWMIAHGIEELLNEGINITFSYSEKL-LH-----ARGTKLHLEKIKFFNSGE 359

  Fly   342 SLINYMKIVEMKGLT---------NVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDGIN 397
            .|:..:..|...|:.         |||..|:         :|:.:....:..:|.|:..  .|.:
plant   360 LLLEKLLKVNFTGIAGQVQFGSGRNVIGCDY---------EIINVNKTDVHTVGFWSKN--GGFS 413

  Fly   398 FTRTFSQKQQEIEANLKNKTLVVTT------------ILSNPYCMRKESAIPL------------ 438
            .....::..|:..:.:.::.|...|            :::       :||.||
plant   414 VVAPKTRHSQKKTSFVSDEKLGDITWPGGGREKPRGWVIA-------DSADPLKIVVPRRVSFVE 471

  Fly   439 ------SGNDQFEGYAVDLIHEISK------------------SLGFNYKIQLVPDGSYGSLNKL 479
                  :.:.:.:|:.:|:..|..|                  |..:|:.||:|.||.|
plant   472 FVTEEKNSSHRIQGFCIDVFIEALKFVPYSVPYIFEPFGNGHSSPNYNHLIQMVTDGVY------ 530

  Fly   480 TGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPL 544
                            |.|:.|:.|...|.:.|||:.|:.:.|:.::.  |.......:.||.|.
plant   531 ----------------DAAVGDIAIVPSRSKLVDFSQPYASTGLVVVI--PANDDNATWIFLRPF 577

  Fly   545 SLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDF 609
            :..:|..:..::|.::|:::||      |.....|..|.......|:|   .|:..:|.::..:.
plant   578 TSRLWCVVLVSFLVIAVVIWIL------EHRINEDFRGPPRRQLSTML---LFSFSTLFKRNQED 633

  Fly   610 LPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDL-AKQTRIKYGALKGGST 673
            ....|: |:|..:|.|..:::.:||||||.:.|||:::.|.|...:.| |.:..|.|.|  |..|
plant   634 TISNLA-RLVMIVWLFLLMVLTASYTANLTSILTVQQLPSAITGIDSLRASEVPIGYQA--GTFT 695

  Fly   674 AAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAK-----GKGSYAFLMESTSIEYVTER 733
            ..:.      ||.     :..||..:....:.|..|:..|     ..|..|.:.|...||.....
plant   696 LEYL------TYS-----LGMARSRLVPLDSTEEYEKALKLGPTNWGGVAAIVDELPYIELFLAE 749

  Fly   734 NCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETS 798
            ......||.....:.:|.|...:||....:::.||||.|..||..::.||..:....||     |
plant   750 RTGFKIVGEPFMHRGWGFAFKRDSPLAIDMSTAILKLSETRKLQEIRKKWLCKTNCAGK-----S 809

  Fly   799 KSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKVAVEERLSAI 850
            ..:...|:|.|.:..|:::|.:.....|.::.|...:.:..:....||.|::
plant   810 NWNPEPNQLHLKSFKGLYLVCIAITVSAFLVFVLRMIRQFVRYRRMERTSSM 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	89/425 (21%)
		ANF_receptor	42..378	CDD:279440	81/395 (21%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	94/423 (22%)
		Lig_chan	547..823	CDD:278489	70/281 (25%)
GLR5	NP_565744.1	PBP1_GABAb_receptor	32..416	CDD:107361	89/428 (21%)
		ANF_receptor	46..396	CDD:279440	81/390 (21%)
		GluR_Plant	458..800	CDD:270404	89/388 (23%)
		Lig_chan	581..832	CDD:278489	70/278 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830