DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and GLR3.5

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001324013.1	Gene:	GLR3.5 / 817800	AraportID:	AT2G32390	Length:	953	Species:	Arabidopsis thaliana

Alignment Length:	930	Identity:	225/930 - (24%)
Similarity:	374/930 - (40%)	Gaps:	213/930 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AQSLPDIIKIGGLFHPADDH----QELAFRQAVDRINADRSILPRSKL--VAQIERISPFDSFHA 81
            :.|||..:.:|.|| ..|..    .:|||..|::.||||:|||..:||  |.|....|.|.....
plant    41 SSSLPSSVNVGALF-TYDSFIGRAAKLAFVAAIEDINADQSILRGTKLNIVFQDTNCSGFVGTMG 104

  Fly    82 GKRVCGLLNIGVAAIFGPQSS---HTASHVQSICDNMEIPHL----------ENRWDYRLRRESC 133
            ..:   |:...|.|..|||||   |..|||   .:.:.:|.|          ..::.|.||...
plant   105 ALQ---LMENKVVAAIGPQSSGIGHIISHV---ANELHVPFLSFAATDPTLSSLQYPYFLRTTQ- 162

  Fly   134 LVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENND----GIVRLQE-LLKAHGMTPFPITVRQLS 193
              |.|...|    |..|.|.::.|:....|:.:::    ||..|.: |.|......:.......:
plant   163 --NDYFQMN----AITDFVSYFRWREVVAIFVDDEYGRNGISVLGDALAKKRAKISYKAAFPPGA 221

  Fly   194 DSGDYRPLLKQIKNSAEAHI-VLDCSTERIHEVLKQAQQIGMMSDYH-----SYLVTSLD----L 248
            |:.....||..: |..|:.| |:..:.:....:...|:.:|||...:     .:|:|:||    |
plant   222 DNSSISDLLASV-NLMESRIFVVHVNPDSGLNIFSVAKSLGMMGSGYVWITTDWLLTALDSMEPL 285

  Fly   249 HTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTT---VRSETALMYDAVHL 310
            ....||..:    .:..||....:  ||..||:....|.|....:|.:   ..|.....||:|.|
plant   286 DPRALDLLQ----GVVAFRHYTPE--SDNKRQFKGRWKNLRFKESLKSDDGFNSYALYAYDSVWL 344

  Fly   311 FAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLIN-------------------YMKIV-EMK-- 353
            .|:|| |:..||...:         |:.:..||.|                   ::::: ||.
plant   345 VARAL-DVFFSQGNTV---------TFSNDPSLRNTNDSGIKLSKLHIFNEGERFLQVILEMNYT 399

  Fly   354 GLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNS----------TLPDGINFTRTFSQKQQE 408
            |||..|:|:.:..|.:...||:.:...|..::|.|::          ||....:.|....|:..|
plant   400 GLTGQIEFNSEKNRINPAYDILNIKSTGPLRVGYWSNHTGFSVAPPETLYSKPSNTSAKDQRLNE 464

  Fly   409 I----------------EANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISK 457
            |                |.....|..|...:....|..:.::  ||.    .:|:.:|:
plant   465 IIWPGEVIKPPRGWVFPENGKPLKIGVPNRVSYKNYASKDKN--PLG----VKGFCIDI------ 517

  Fly   458 SLGFNYKIQLVP-----------DGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQA 511
               |...|||:|           ||      |....::.:|.|:.....|:|:.|:||...|.:.
plant   518 ---FEAAIQLLPYPVPRTYILYGDG------KKNPSYDNLISEVAANIFDVAVGDVTIITNRTKF 573

  Fly   512 VDFTTPFMNLGVSILYRKPIK-QPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWP 575
            ||||.||:..|:.::  .|:| ...:.:|||.|.::::|......:|.|..:::||.
plant   574 VDFTQPFIESGLVVV--APVKGAKSSPWSFLKPFTIEMWAVTGALFLFVGAVIWILE-------- 628

  Fly   576 AYTDAHGEKVESQF------TLLNCMWFAIGSLMQQGCDFLPKALST--RMVAGIWWFFTLIMIS 632
                   .:...:|      .::...||:..::.   .......:||  |.|..:|.|..||:.|
plant   629 -------HRFNEEFRGPPRRQIITVFWFSFSTMF---FSHRENTVSTLGRFVLLVWLFVVLIINS 683

  Fly   633 SYTANLAAFLTVERMDSPIESAEDL-AKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFME--- 693
            ||||:|.:.|||:::.|.||..:.| |....|   .::.|:.|              |.|:.
plant   684 SYTASLTSILTVQQLTSRIEGMDTLIASNEPI---GVQDGTFA--------------WKFLVNEL 731

  Fly   694 SARPSVFTASNGE-----GVERVAKGKGSYAFLMESTSIE-YVTERNCELTQVGGMLDTKSYGIA 752
            :..||.......|     .::|..:|.|..|.:.|...|: .::..||:...||.......:|.|
plant   732 NIAPSRIIPLKDEEEYLSALQRGPRGGGVAAIVDELPYIKALLSNSNCKFRTVGQEFTRTGWGFA 796

  Fly   753 TPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFV 817
            ...:||....:::.||:|.|||||..::.||.....   :|.::.|.:.:  .::.:.:..|:|:
plant   797 FQRDSPLAVDMSTAILQLAEEGKLEKIRKKWLTYDH---ECTMQISDTEN--YQISVQSFWGLFL 856

  Fly   818 VLMGGMGVACVIAVCEFVWK 837
            :    .||...||:..|.||
plant   857 I----CGVVWFIALTLFCWK 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	108/434 (25%)
		ANF_receptor	42..378	CDD:279440	99/394 (25%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	98/399 (25%)
		Lig_chan	547..823	CDD:278489	66/293 (23%)
GLR3.5	NP_001324013.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830