DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and gria1a

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	894	Identity:	345/894 - (38%)
Similarity:	515/894 - (57%)	Gaps:	88/894 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLQLILNCRKAQSLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISPF 76
            ||....|......|.|..|.||||| |.:.|:...||.|:    :....:|  |||.|::.:...
Zfish     7 LLCTSFLGLCFGSSFPSNINIGGLF-PTESHEYEVFRFAL----SHHQDIP--KLVPQVDMVKLG 64

  Fly    77 DSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL--------ENRWDYRLRRESC 133
            :||......|...:.||.||.|.....|.:.:.|.|..:.:..:        .|::..:||.|
Zfish    65 NSFSMTYAFCSQFSKGVYAIIGVYDRKTVNMLMSFCGALHVCFVTPSFPMENSNQFVIQLRPE-- 127

  Fly   134 LVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKA---HGMTPFPITVRQLSDS 195
                      |..|.|.::.|:.|..|..:|.::.|:..||::|..   |......:.|..::::
Zfish   128 ----------LQDALVGVIEHYRWSKFVYMYSSDSGLSVLQKVLDTAAEHNWLVTSVNVETMTEA 182

  Fly   196 GDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYG 259
             .:..:.:.:....|..|::||..||:..:||:..::|. :..|| |::.:|....::|.||:.|
Zfish   183 -SFLKVFQDLDKKKEGQIIIDCELERLTSILKKIIELGKNVKSYH-YILANLGFLDIDLTEFKKG 245

  Fly   260 GTNITGFRLIN--EKIVSDVVRQW----SIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDL 318
            ..|:|||:|:|  :..||..|:||    :.|.|...|....|     .||.||.|.:.:.|..:|
Zfish   246 EANVTGFQLVNYADPNVSRTVQQWMEFDNKDAKVPKRRLKYT-----GALTYDGVKVMSTAFQNL 305

  Fly   319 DTSQQIDIHPISCDGQ------STWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVEL 377
             ..|:|||......|:      :.|..|..:...::.|.::|||..|:|:.:|.||::.:.::||
Zfish   306 -RRQRIDISRRGNAGECLANPPAPWGQGIDIQRALQQVRIEGLTGHIQFNEKGRRTNYSISVMEL 369

  Fly   378 TPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIEA-NLKNKTLVVTTILSNPYCMRKESAIPLSGN 441
            .|.|.:|:|.||    :...|..|.:......|. .|:|:|.:|||||.:||.|.|::....:||
Zfish   370 RPTGPKKVGYWN----EDEKFVSTAAYMPGSNETYGLQNRTYIVTTILESPYVMLKKNHEHFTGN 430

  Fly   442 DQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITF 506
            |::|||.|:|..||:|.:|::|.:::|.||.||:.:..|..||||:.||:..:||:|:|.||||.
Zfish   431 DKYEGYCVELAAEIAKHVGYHYILKIVADGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITL 495

  Fly   507 EREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTP 571
            .||:.:||:.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:|
Zfish   496 VREEVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSP 560

  Fly   572 YEW---------------PAYTDAH-GEKVESQ----------FTLLNCMWFAIGSLMQQGCDFL 610
            |||               |:.:.|. |:..::|          |.:.|.:||::|:.||||||..
Zfish   561 YEWHADDCEDGAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGCDIS 625

  Fly   611 PKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAA 675
            |::||.|:|.|:|||||||:|||||||||||||||||.|||||||||||||.|.||.|..|||..
Zfish   626 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKE 690

  Fly   676 FFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQ 739
            |||.|||:.:::|||:|:||.||||..:..|||.||.|.||.||:|:|||..||:.:|. |:..:
Zfish   691 FFRRSKIAVFEKMWSYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMK 755

  Fly   740 VGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAA 804
            |||.||:|.||||||..||.|..:|..:|||.|:|.|..||.|||.:|   |:|......|....
Zfish   756 VGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKDKT 817

  Fly   805 NELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKVAVEERLSAILNE 853
            :.|.|:||.|||.:|:||:|:|.::|:.||.:|||  ....|:...:|:
Zfish   818 SALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSR--TESRRMKQSIND 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	106/389 (27%)
		ANF_receptor	42..378	CDD:279440	93/359 (26%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	204/396 (52%)
		Lig_chan	547..823	CDD:278489	153/302 (51%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	106/391 (27%)
		ANF_receptor	36..369	CDD:279440	92/358 (26%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	207/404 (51%)
		Lig_chan	536..836	CDD:278489	153/302 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820