DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and grik1a

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	863	Identity:	406/863 - (47%)
Similarity:	574/863 - (66%)	Gaps:	59/863 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IIKIGGLFHPADDH----QELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLL 89
            :|:|||:|...::.    .||||:.||..||.:|:::|.:.|...|:|::.||||.|.:|||..|
Zfish    38 VIRIGGIFETRENEPVSMDELAFKFAVTSINRNRTLMPNTTLTYDIQRVNLFDSFEASRRVCDQL 102

  Fly    90 NIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRL--RRESCLVNLYPHPNTLSKAYVDIV 152
            .:||||:|||..|.:.|.|||||:.:|:||::.||.:..  .:::..:||||...::|:|.:|||
Zfish   103 ALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDNFYINLYPEYTSISRAILDIV 167

  Fly   153 RHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQL-SDSGDYRPLLKQIKNSAEAHIVLD 216
            ..:.||..|::||::.|::|:|||:||.......|.:||| |..||.|||||::|...|.:::.|
Zfish   168 IFYKWKCVTVVYEDSTGLMRMQELIKAPSKNNLKIRIRQLPSGGGDSRPLLKEMKKEKEFYVIFD 232

  Fly   217 CSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLIN--EKIVSDVVR 279
            ||.:...|:|||...:|||::|:.:..|:|||..::|:.:||.|.|:|.|||:|  :..|:.|::
Zfish   233 CSYQVAAELLKQLMSMGMMTEYYHFFFTTLDLFALDLEPYRYSGVNMTAFRLLNLDDSYVASVIQ 297

  Fly   280 QWSID--------EKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQST 336
            :||::        |.||: |..:||.   .|||||||.:.|.|   ...:.|:.:..:.|.....
Zfish   298 KWSMERQLAPPKPESGLM-SGIMTTA---AALMYDAVFMVAVA---SQRATQMTVSSLQCHRHKP 355

  Fly   337 WQHGFSLINYMKIVEMKGLTNVIKFDH-QGFRTDFMLDIVELTPAGI---------------RKI 385
            |::|...:|..|..:..|||..|..:. .|.|.:|.||::.|...|.               .||
Zfish   356 WRYGPRFMNLFKEAQWDGLTGRIVLNKTDGLRKEFNLDLISLKEDGTAKRVADGASRPNKLWTKI 420

  Fly   386 GTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVD 450
            |.|||.  .|:|.|.....|  .|..:|.|:||:|||||.|||.|.|:|...|.|||:||||.:|
Zfish   421 GVWNSY--TGLNLTEIKDNK--NITDSLANRTLIVTTILENPYVMYKKSDKVLYGNDRFEGYCLD 481

  Fly   451 LIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFT 515
            |:.|:|..|||.|:::||.||.||:.|. .||||||:|||::..||||:|.||||:.||:.:||:
Zfish   482 LLKELSNILGFTYEVKLVTDGKYGAQND-KGEWNGMVRELIDHIADLAVAPLTITYVREKVIDFS 545

  Fly   516 TPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEW--PAYT 578
            .|||.||:|||||||....|.:||||:||:.|:|:|:..|.||||.:||::|:||||||  |...
Zfish   546 KPFMTLGISILYRKPNGTNPGVFSFLNPLTPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPC 610

  Fly   579 DAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLT 643
            :...|.||:.|||||.:||.:.:||:||.:.:|||||||::.|||||||||:|||||||||||||
Zfish   611 NPSSEVVENNFTLLNSLWFGVAALMRQGSELMPKALSTRILGGIWWFFTLIIISSYTANLAAFLT 675

  Fly   644 VERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGV 708
            ||||||||:||:||||||||:|||::.|||..||:.||||||::||:||.|.:.:....::.:|:
Zfish   676 VERMDSPIDSADDLAKQTRIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRKNTALVKNSKDGI 740

  Fly   709 ERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEE 773
            .||.  ...||.|||||||||:|:|||.||||||::|:|.||:.||..||||..:...||:||||
Zfish   741 TRVL--TTDYALLMESTSIEYITQRNCNLTQVGGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEE 803

  Fly   774 GKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKS 838
            ||||::|.|||   ||.| |..|.||.:||   ||:.|:||:|:||..|:.::..:|:.||::||
Zfish   804 GKLHMMKEKWW---RGNG-CPEEDSKEASA---LGVENIGGIFIVLAAGLVLSVFVAIGEFIYKS 861

  Fly   839 RKVA-VEE--RLSAILNE 853
            .|.: :||  ..||::.:
Zfish   862 HKNSDIEECVSFSAVMED 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	148/398 (37%)
		ANF_receptor	42..378	CDD:279440	135/353 (38%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	223/371 (60%)
		Lig_chan	547..823	CDD:278489	163/277 (59%)
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141	150/402 (37%)
		ANF_receptor	57..398	CDD:279440	135/347 (39%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	224/374 (60%)
		Lig_chan	577..846	CDD:278489	163/277 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1884
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	800	1.000	Inparanoid score	I479
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm24781
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.780