DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and Grid2

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	905	Identity:	270/905 - (29%)
Similarity:	426/905 - (47%)	Gaps:	164/905 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGV 93
            ||.||.:|..:....:..||.||..:|.:..||...|:...:..:...:.|.|.:..|.|:|.|:
  Rat    26 IIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGI 90

  Fly    94 AAIFGPQSSHTASHVQSICDNMEIPHL------------------ENR-WDYRLRRESCLVNLYP 139
            .|:.......:|..:||:.|.|.||||                  .|| .||.|       ::.|
  Rat    91 LALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTL-------SVRP 148

  Fly   140 HPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSDSGDYRPLLKQ 204
             |..|::..:.:|..:.|:.|.|.|::...|..:||.|.            ::|..| ....|::
  Rat   149 -PVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLD------------KVSQQG-MDVALQK 199

  Fly   205 IKNSAEAHIVLDCSTERIHE-------------VLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEF 256
            ::|:....|.....|.||.|             |:..|.....:|:.....:.:.|.|.:.::|
  Rat   200 VENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINE- 263

  Fly   257 RYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLR--------------------SANLTTVRSET 301
                       .||:..|.::||: ||....::|                    |:.|...:...
  Rat   264 -----------EINDVDVQELVRR-SIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPF 316

  Fly   302 A--------LMYDAVHLFAKALH-DLDTSQQIDIHPISC--DGQSTWQHGFSLINYMKIVEMKGL 355
            |        .:||.|.|.|.|.| .|:..:...:..:||  .....||.|.|::..:|...:.||
  Rat   317 AQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGL 381

  Fly   356 TNVIKFDHQGFRTDFMLDIV-----ELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLKN 415
            |..::|...|...:...:|:     |....|:||:|.||..  .|:|.:.|    .:::|.|::.
  Rat   382 TGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPV--TGLNGSLT----DKKLENNMRG 440

  Fly   416 KTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLT 480
            ..|.|.|:|..|:.|..|:.  |....:::|:::|::..:|..|||||:|.:.||..|||..: .
  Rat   441 VVLRVVTVLEEPFVMVSENV--LGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQE-D 502

  Fly   481 GEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLS 545
            |.|||::.||:.:|||:.|:.||||.:||..|||||.:|:..|.:|.|: .::..::|:.|:|..
  Rat   503 GTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRR-AEKTVDMFACLAPFD 566

  Fly   546 LDVWIYMATAYLGVSVLLFILAKFTP--YEWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCD 608
            |.:|..:|...|.|.:|:::|....|  .:..:.|..         ||.|.|||..||.:|||.:
  Rat   567 LSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTST---------TLYNSMWFVYGSFVQQGGE 622

  Fly   609 FLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGA------ 667
            .....|:|||:.|.||.|.||:|||||||||||||:.|::|.|:|.:||:|||.|.||.
  Rat   623 VPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAV 687

  Fly   668 -----LKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGE---------GVERVAKGKGSY 718
                 :||  ...|.||   |.|.:||        .:...|||.         |:::|.  .|:|
  Rat   688 YQHVRMKG--LNPFERD---SMYSQMW--------RMINRSNGSENNVLESQAGIQKVK--YGNY 737

  Fly   719 AFLMESTSIEYV--TERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKT 781
            ||:.::..:|||  .:.:|....||..:..:.||||....||||...:..||:||:.|.:.|||.
  Rat   738 AFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKH 802

  Fly   782 KWWKEKRGGGKCRVETS-KSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRK 840
            |||.:   .|:|.:.:| .:......|.:.::.|||.:|..|:.::|:|||.|..|..||
  Rat   803 KWWPK---NGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRK 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	99/433 (23%)
		ANF_receptor	42..378	CDD:279440	89/403 (22%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	147/393 (37%)
		Lig_chan	547..823	CDD:278489	105/300 (35%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		80/352 (23%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	100/436 (23%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	147/393 (37%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810