DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and grin2aa

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_021329529.1	Gene:	grin2aa / 563297	ZFINID:	ZDB-GENE-070424-129	Length:	1460	Species:	Danio rerio

Alignment Length:	917	Identity:	209/917 - (22%)
Similarity:	373/917 - (40%)	Gaps:	169/917 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLVLPLLLLQLILNCRKAQSLP--DIIKIGGLFHPADDHQELAFRQAVDRINADRSIL------P 62
            :|.|| .||.||.....|:.:|  :|..|.|......|....|.....|.|:.:...|      |
Zfish    13 LLTLP-ALLTLISISHAAEKVPILNIAVILGQTRYISDRDIRALWSKDDPIDVNVVTLLVNETDP 76

  Fly    63 RSKLVAQIERISPFDSFHAGKRVCGLL------NIGVAAIFGPQSSHTASHV-------QSICDN 114
            :|.:....:.:|       |.::.|::      ...:|.|....||.|...:       ..|..:
Zfish    77 KSIITHVCDLMS-------GTKIHGVVFGDGTDQEAIAQILDFISSQTLIPILGIHGGSSMIMAD 134

  Fly   115 MEIPHLENRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKA 179
            .::.....::...:::|:.|:             ::|:..:.|..|:|:.....|......:||.
Zfish   135 KDVKSTFFQFGASIQQEALLM-------------LNIMEEYDWHVFSIVTSKFPGYQDFIAILKT 186

  Fly   180 HGMTPFP-------ITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSD 237
            .....|.       ||:..:  .||.|..: |:|......::|.||.:....:|::|:.:|:...
Zfish   187 TVDNSFVGWDLQHIITLDAV--DGDSRTQI-QLKKVQSPVVLLYCSKDEAAYILEEARSLGLTGF 248

  Fly   238 YHSYLVTSLDLHT--VNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTTVRSE 300
            .:.::|.||....  :..|.|..|             ::|.....|....:..:|. .|..:.:.
Zfish   249 GYIWIVPSLTTGNPEITPDTFPSG-------------MISVSYDDWDYPLEARVRD-GLGIITTA 299

  Fly   301 TALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQ--STWQHGFSLINYMKIVEMKGLTNVIKFDH 363
            .|.|             |:....|.....||.||  .|.....:|..||..|...|  ..:.|..
Zfish   300 AAAM-------------LEEFGDIPEAKTSCYGQMEKTKLPPSALHKYMMNVTWDG--KDLSFTE 349

  Fly   364 QGFRTDFMLDIVELT-PAGIRKIGTW-NSTL----PDGINFTRTFSQKQQEIEANLKNKTLVVTT 422
            .|::....|.::.|. .....|:|.| |.:|    |....| .:|.      :|...:..|.:.|
Zfish   350 DGYQVHPKLVVIVLNKDREWEKMGKWENQSLTLKYPVWPRF-NSFG------DAETDDNHLTIVT 407

  Fly   423 ILSNPY------------CMRKESAIP---------LSGNDQF-----EGYAVDLIHEISKSLGF 461
            :...|:            |||  :::|         ..|...:     :|:.:|::.:|::::.|
Zfish   408 LEEKPFVIVENVERLTGTCMR--NSVPCRKHIKDNTTEGGGTYIKKCCKGFCIDILKKIARNVKF 470

  Fly   462 NYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSIL 526
            .|.:.||.:|.:|  .|:...||||:.|::.::|.:|:..|||..||.:.:||:.||:..|:|::
Zfish   471 TYDLYLVTNGKHG--KKINNVWNGMVGEVVNKKAVMAVGSLTINEERSEVIDFSVPFVETGISVM 533

  Fly   527 Y-RKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVL-LFILAKFTPYEW----PAYTDAHGEKV 585
            . |......|:  :||.|.|..||:.|....|.|:.: :|:....:|..:    ....|.||
Zfish   534 VSRSNGTVSPS--AFLEPFSASVWVMMFVMLLLVTAMAVFMFEYISPLGFNRNLAQGKDPHG--- 593

  Fly   586 ESQFTLLNCMWFAIGSLMQQGCDFL-PKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDS 649
             ..||:...:|...|.:........ ||..:::.:..:|.||.:|.::|||||||||:..|....
Zfish   594 -PSFTMGKAVWLLWGLVFNNSVPVQNPKGTTSKFIVSVWAFFAVIFLASYTANLAAFMIQEEFVD 657

  Fly   650 PIESAEDLAKQTRIKY------GALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGV 708
            .:....|...|:...|      |.:..|||....|.:....:|.|..:.:       |..| :.:
Zfish   658 QVTGLSDKKFQSPYSYSPPFRFGTVPNGSTERNIRKNYPDMHQYMVKYHQ-------TGVN-DAL 714

  Fly   709 ERVAKGKGSYAFLMESTSIEYVTERN--CELTQVGG--MLDTKSYGIATPPNSPYRTAINSVILK 769
            ..:..||.. ||:.::..:.|:..|:  |:|..:|.  :..|..||||....|.::..::..||.
Zfish   715 VSLKTGKLD-AFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIALQKGSLWKRPVDLAILA 778

  Fly   770 LQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCE- 833
            :..:|::..|:.:|..     |.|..|  |:...:::|.:.|:.|||.:|...||::.:..|.|
Zfish   779 IIGDGEMEELEAQWLT-----GICHNE--KNEVMSSQLDVDNMAGVFYMLATAMGLSLITFVWEH 836

  Fly   834 -FVWKSR 839
             |.|:.|
Zfish   837 LFYWRLR 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	75/401 (19%)
		ANF_receptor	42..378	CDD:279440	65/365 (18%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	104/412 (25%)
		Lig_chan	547..823	CDD:278489	72/291 (25%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373	77/407 (19%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	106/422 (25%)
		NMDAR2_C	836..1460	CDD:313729	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810