DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and grik1b

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	871	Identity:	417/871 - (47%)
Similarity:	584/871 - (67%)	Gaps:	60/871 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LQLILNCRKAQ---SLPDIIKIGGLFHPADDH----QELAFRQAVDRINADRSILPRSKLVAQIE 71
            :..||.|..|:   |...:::|||:|...::.    :||||:.||..||.:|:::|.:.|...|:
Zfish    45 VSFILLCLMAEVGLSAQQVLRIGGIFETLENEPISVEELAFKFAVTNINRNRTLMPNTTLTYDIQ 109

  Fly    72 RISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRL--RRESCL 134
            ||:.||||.|.:|.|..|.:||||:|||..|.:.|.|||||:.:|:||::.||.:..  .::|..
Zfish   110 RINLFDSFEASRRACDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDSFY 174

  Fly   135 VNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQL-SDSGDY 198
            :||||...::|:|.:|||:.:.||..|::||:..|::|||||:||.......|.:||| :.|.|.
Zfish   175 INLYPDYASISRAVLDIVQFYKWKAVTVVYEDATGLIRLQELIKAPSRYSIKIKIRQLPTGSKDA 239

  Fly   199 RPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNI 263
            |||||::|...|..::.|||.:...:||||...:|||::|:.:..|:|||::::|:.|||.|.|:
Zfish   240 RPLLKEMKKGKEFCVIFDCSYQTAADVLKQLLSMGMMTEYYHFFFTTLDLYSLDLEPFRYSGVNM 304

  Fly   264 TGFRLIN--EKIVSDVVRQWSID--------EKGLLRSANLTTVRSETALMYDAVHLFAKALHDL 318
            |||||:|  ...|:.||.:||::        |.| |:...:||   |.|||||||::.|.|   .
Zfish   305 TGFRLLNIDNPQVASVVEKWSMERLQAPPKPETG-LQDGMMTT---EAALMYDAVYMVAAA---S 362

  Fly   319 DTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVI---KFDHQGFRTDFMLDIVELTPA 380
            ..:.||.:..:.|.....|:.|...|:..|..:..|||..|   |.|  |.|.||.|||:.|...
Zfish   363 QRASQITVSSLQCHRHKPWRFGSRFISMFKEAQWNGLTGQIIINKTD--GLRKDFDLDIISLKED 425

  Fly   381 GI-------------RKIGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRK 432
            |:             :|||.|||.  .|:|.|.:...|...:..::.|:||:|||||.|||.|.|
Zfish   426 GLEKPLESGRFNKVWKKIGVWNSN--TGLNLTDSNKDKNTNVTDSMANRTLIVTTILENPYVMYK 488

  Fly   433 ESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADL 497
            :|..||.|||:||||.:||:.|:|..|||:|:::||.||.||:.|. .||||||:|||::..|||
Zfish   489 KSDKPLYGNDRFEGYCLDLLKELSNILGFSYEVKLVTDGKYGAQND-KGEWNGMVRELIDHVADL 552

  Fly   498 AIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVL 562
            |:|.||||:.||:.:||:.|||.||:||||.||....|.:||||:|||.|:|:|:..|.||||.:
Zfish   553 AVAPLTITYVREKVIDFSKPFMTLGISILYHKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCV 617

  Fly   563 LFILAKFTPYEW--PAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWF 625
            ||::|:||||||  |...:...:.||:.|||:|.:||.:|:|||||.:.:|||||||:|.|||||
Zfish   618 LFVIARFTPYEWYNPHPCNPDSDVVENNFTLINSVWFGVGALMQQGSELMPKALSTRIVGGIWWF 682

  Fly   626 FTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWS 690
            ||||:|||||||||||||||||||||:||:||||||:|:|||::.|||..||:.||||||::||:
Zfish   683 FTLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWA 747

  Fly   691 FMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPP 755
            ||.|.:.:....:|.||::||.  ...||.|||||||||:::|||.|||:||::|:|.||:.||.
Zfish   748 FMSSRKNTALVKNNREGIQRVL--TTDYALLMESTSIEYISQRNCNLTQIGGLIDSKGYGVGTPI 810

  Fly   756 NSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLM 820
            .||||..:...||:||||||||::|.|||   ||.| |..|.||.:||   ||:.|:||:|:||.
Zfish   811 GSPYRDKVTIAILQLQEEGKLHMMKEKWW---RGNG-CPEEDSKEASA---LGVENIGGIFIVLA 868

  Fly   821 GGMGVACVIAVCEFVWKSRK-VAVEE 845
            .|:.::..:|:.||::|||| :.:||
Zfish   869 AGLVLSVFVAIGEFIYKSRKNLDIEE 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	157/398 (39%)
		ANF_receptor	42..378	CDD:279440	144/355 (41%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	224/371 (60%)
		Lig_chan	547..823	CDD:278489	163/277 (59%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	158/403 (39%)
		ANF_receptor	80..423	CDD:279440	144/351 (41%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	225/374 (60%)
		Lig_chan	602..871	CDD:278489	163/277 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1884
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	800	1.000	Inparanoid score	I479
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm24781
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880