DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and grin2bb

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	876	Identity:	206/876 - (23%)
Similarity:	358/876 - (40%)	Gaps:	187/876 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PRSKLVAQIERISPFDSFHAGKRVCGLL--NIGVAAIFGPQSSHTASHVQSICD----NMEIPHL 120
            |:.:||...|.    |......|:|.|:  |.....:||..:...|  :..|.|    ...||.|
Zfish   140 PKVELVTMNET----DPKSIINRICALMSRNWLQGVVFGDDTDQEA--IAQILDFISAQTHIPIL 198

  Fly   121 ENRWDYRL-----RRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTII---YENNDGIV------ 171
            ..|....:     ...|......|.....:...::|:..:.|..|:|:   |..:...|
Zfish   199 GIRGGSSMIMAAKDDHSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYYPGHQDFVNRIRST 263

  Fly   172 --------RLQELLKAHGMTPFPITVRQLS-DSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLK 227
                    .|:|:|           :..:| |.||.: :..|:|......|:|.|:.|....:.:
Zfish   264 VDNSFVGWELEEVL-----------LLDMSVDDGDSK-IQNQMKKLQSPVILLYCTKEEATTIFE 316

  Fly   228 QAQQIGMMSDYHSYLVTSL--------------DLHTVNLDEFRYGGTNITGFRLINEKIVSDVV 278
            .|..:|:....::::|.||              .|.:|:.||:.||          .|..|.|.|
Zfish   317 VAHSVGLTGYGYTWIVPSLVAGDTDNVPNVFPTGLISVSYDEWDYG----------LEARVRDAV 371

  Fly   279 RQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFS- 342
            .              :..:.:.|.::....|...|:               .|.|....:...|
Zfish   372 A--------------IIAMATSTMMLDRGPHTLLKS---------------GCHGAPDKKGSKSG 407

  Fly   343 ----LINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELT-PAGIRKIGTW-NSTLPDGINFTRT 401
                ::.|:..|..:|..  :.|...||:....|.|:.|. .....::|.| |.:|....:....
Zfish   408 NPNEVLRYLMNVTFEGRN--LSFSEDGFQMHPKLVIILLNKERQYERVGKWENGSLAMKYHVWPR 470

  Fly   402 FSQKQQEIEANLKNKT---LVVTTILSNPY------------CMRKESAIP---------LSGND 442
            |     |:.::.:.:.   |.:.|:...|:            |||  :.:|         |:|:.
Zfish   471 F-----ELYSDAEEREDDHLSIVTLEEAPFVIVEDVDPLSGTCMR--NTVPCRKQLKLQNLTGDS 528

  Fly   443 QF------EGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIAD 501
            ..      :|:.:|::.:|:||:.|.|.:.||.:|.:|  .|:.|.||||:.|::.:.|.:|:..
Zfish   529 GIYIKRCCKGFCIDILKKIAKSVKFTYDLYLVTNGKHG--KKINGTWNGMVGEVVLKNAHMAVGS 591

  Fly   502 LTITFEREQAVDFTTPFMNLGVSILY-RKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVS-VLLF 564
            |||..||.:.:||:.||:..|:|::. |......|:  :||.|.|.|||:.|....|.|| |.:|
Zfish   592 LTINEERSEVIDFSVPFIETGISVMVSRSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVF 654

  Fly   565 ILAKFTPYEWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFL-PKALSTRMVAGIWWFFTL 628
            :...|:|..:........|.....||:...:|...|.:........ ||..:::::..:|.||.:
Zfish   655 VFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAV 719

  Fly   629 IMISSYTANLAAFLTVER--------MDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTY 685
            |.::|||||||||:..|.        .|...:...|.:...|  :|.:..|||....|::    |
Zfish   720 IFLASYTANLAAFMIQEEYVDQVTGLSDKKFQHPNDFSPPFR--FGTVPNGSTERNIRNN----Y 778

  Fly   686 QRMWSFMESARPSVFTASN-GEGVERVAKGKGSYAFLMESTSIEYVTERN--CELTQVGG--MLD 745
            :.|.|:|.|     |...| .|.:..:..||.. ||:.::..:.|:..|:  |:|..:|.  :..
Zfish   779 KEMHSYMTS-----FHQKNVNEALHSLKSGKLD-AFIYDAAVLNYMAGRDEGCKLVTIGSGYIFA 837

  Fly   746 TKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLA 810
            |..||||...:|.::.|::..||:|..:|::..|:..|..     |.|..|  |:...:::|.:.
Zfish   838 TTGYGIAIQKDSGWKRAVDLAILQLFGDGEMEELEALWLT-----GICHNE--KNEVMSSQLDVD 895

  Fly   811 NVGGVFVVLMGGMGVACVIAVCE--FVWKSR 839
            |:.|||.:|...|.::.:..:.|  |.|:.|
Zfish   896 NMAGVFYMLGAAMALSLITFIAEHLFYWQLR 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	73/384 (19%)
		ANF_receptor	42..378	CDD:279440	68/363 (19%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	116/415 (28%)
		Lig_chan	547..823	CDD:278489	80/290 (28%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373	73/388 (19%)
		ANF_receptor	138..442	CDD:279440	67/360 (19%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	118/422 (28%)
		Lig_chan	636..908	CDD:278489	80/290 (28%)
		NMDAR2_C	919..1770	CDD:287527	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810