Protein Alignment KaiR1D and Gria3

DIOPT Version :10

• Sequence 1: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_058582.4
• Gene: Gria3 / 53623
• MGIID: 95810
• Length: 888
• Species: Mus musculus
• Alignment Length: 856
• Identity: 331/856 - (38%)
• Similarity: 512/856 - (59%)
• Gaps: 54/856 - (6%)

  Fly    27 PDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRS-KLVAQIERISPFDSFHAGKRVCGLLN 90
            |:.|.|||||......:..|||.||...|.:::...:. .|...::.:...:||......|...:
Mouse    25 PNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFS 89

  Fly    91 IGVAAIFGPQSSHTASHVQSICDNME----IPHLENRWDYRLRRESCLVNLYPHPNTLSKAYVDI 151
            .||.||||.....:.:.:.|.|..:.    .|......|.:.     ::.:.|   .|..|.:.:
Mouse    90 RGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQF-----VIQMRP---ALKGAILSL 146

  Fly   152 VRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVR---QLSDSGDYRPLLKQIKNSAEAHI 213
            :.::.|:.|..:|:...|...||.:::|.....:.:|.|   .:.|..::|.:::::....|...
Mouse   147 LGYYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDIQEFRRIIEEMDRRQEKRY 211

  Fly   214 VLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLINEK--IVSD 276
            ::||..|||:.:|:|...:|..|..:.|::.:|....:.|:...:||.|||||:::|.:  :|..
Mouse   212 LIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDIVLERVMHGGANITGFQIVNNENPMVQQ 276

  Fly   277 VVRQW-SIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQS----- 335
            .:::| .:||:....:.| ..::..:||.:||:.:.|:|...| ..|::|:......|..
Mouse   277 FIQRWVRLDEREFPEAKN-APLKYTSALTHDAILVIAEAFRYL-RRQRVDVSRRGSAGDCLANPA 339

  Fly   336 -TWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDGINFT 399
             .|..|..:...:|:|:::|:|..|:||..|.||::.:|:.|:..:|.||.|.||       .:.
Mouse   340 VPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWN-------EYE 397

  Fly   400 RTFSQKQQEI---EANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGF 461
            |......|:|   .::.:|:|:||||||.:||.|.|::...|.||:::|||.|||.:||:|.:..
Mouse   398 RFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRI 462

  Fly   462 NYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSIL 526
            .||:.:|.||.||:.:..|..||||:.||:..|||:|:|.||||..||:.:||:.|||:||:||:
Mouse   463 KYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIM 527

  Fly   527 YRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVE----- 586
            .:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||  :.:.:.|:..
Mouse   528 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW--HLEDNNEEPRDPQSP 590

  Fly   587 ----SQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERM 647
                ::|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:|||||||||||||||||
Mouse   591 PDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 655

  Fly   648 DSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVA 712
            .|||||||||||||.|.||.|..|||..|||.|||:.|::|||:|:||.|||||.:..:||.||.
Mouse   656 VSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVR 720

  Fly   713 KGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKL 776
            |.||.:|||:|||..||:.:|. |:..:|||.||:|.||:|||..|..||.:|..:|||.|:|.|
Mouse   721 KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGIL 785

  Fly   777 HILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKV 841
            ..||.|||.:|   |:|..:.|.|....:.|.|:||.|||.:|:||:|:|.::|:.||.:|||
Mouse   786 DKLKNKWWYDK---GECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSR-- 845

  Fly   842 AVEERLSAILN 852
            |..:|:....|
Mouse   846 AESKRMKLTKN 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	95/385 (25%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	204/379 (54%)
Gria3	NP_058582.4	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	96/390 (25%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	207/387 (53%)