DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and grin2da

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	857	Identity:	191/857 - (22%)
Similarity:	348/857 - (40%)	Gaps:	178/857 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PRSKLVAQIER--------ISPFDSFHAGKRVCGLLNIGVAAIFG--PQSSHTASHVQSICDNME 116
            |...||.:.|:        ::|...|.:.:....::.:|..|..|  ||.|.:. ::|..|..
Zfish   138 PLQGLVFEEEKPPPPNRAPLAPMLEFVSAQTGVPVIAVGGGAGLGREPQESGSV-YLQFSCST-- 199

  Fly   117 IPHLENRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTII------YENNDGIVRLQE 175
                    |.:|                 :...:::..:.|..|:::      ||  |.:..::.
Zfish   200 --------DLQL-----------------EVIFEVLEEFDWTAFSVVTTRHHGYE--DFLAMVEG 237

  Fly   176 LLKAH--GMTPFPITVRQLSD---SGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMM 235
            ::...  |.....:.:..|:|   ....|.|||:  |.|:..: |.||.|...::.|.|...|..
Zfish   238 MIDGSFIGWERKSVVMLNLTDDPGGARTRRLLKE--NEAQVRL-LYCSQEEAEQIFKAAWASGQA 299

  Fly   236 SDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTTVRSE 300
            :..|.:...               |..::|..|.........||.....::...|.|...:|.:.
Zfish   300 TPSHMWFAV---------------GPGLSGLGLEGLPKALFAVRPQGWRDEPRRRIAKGVSVLTH 349

  Fly   301 TALMYDAVHLFAKALHDLDTSQQIDIHPISC--DGQSTWQHGFSLINYMKIVEMKGLTNVIKFDH 363
            .|:.....:..|:.     ||     ...:|  ||..| |.....|.:...:.:.|  ....|::
Zfish   350 GAMALRREYGGARG-----TS-----FAGNCMMDGNQT-QRVPGRIRFFSNITLSG--RDYSFNN 401

  Fly   364 QGFRTDFMLDIVELTPA-GIRKIGTWNSTLPDGI------------NFTRTFSQKQQEIEANLKN 415
            .|:..:.:||::..|.. |..::|.|.    :|:            .|.:.....|.
Zfish   402 DGYLANPLLDVISYTAGRGWEEVGWWE----NGVLRLRYPPWSRYGPFLKPLDDSQH-------- 454

  Fly   416 KTLVVTTILSNPY------------CMRKE--SAIPLSGNDQFE----------GYAVDLIHEIS 456
              |.|.|:...|:            |:|..  ..:||:.:...|          |:.:|::..::
Zfish   455 --LRVVTLEERPFVIVEPADPGTGSCIRDSVPCRLPLNNSMVVEGIQSMKHCCKGFCIDVLKRLA 517

  Fly   457 KSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNL 521
            |.:||.|.:.||.:|.:|  ..:.|:||||:.|::.:|||:||..|||..||.:.|:|:.||:..
Zfish   518 KIVGFTYDLYLVTNGRHG--KNIDGQWNGMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFVET 580

  Fly   522 GVSILY-RKPIKQPPNLFSFLSPLSLDVWIYMATAYLG-VSVLLFILAKFTPYEWPAYTDAHGEK 584
            |:|::. |......|:  :||.|.|..||:.|....|. |:|.:||...|:|..:.....:....
Zfish   581 GISVMVSRSNGTVSPS--AFLEPYSPAVWVMMFVMCLSVVAVTVFIFEFFSPVGYNRSLQSGKTA 643

  Fly   585 VESQFTLLNCMWFAIGSLMQQGCDF-LPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMD 648
            ..|:||:...:|.....:....... .|:..:::::..:|.||.:|.::|||||||||:..|...
Zfish   644 GGSKFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYI 708

  Fly   649 SPIESAEDLAKQ------TRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEG 707
            ..:....|...|      ..:::|.:..|||....|    |.|..|..:|        ..:|..|
Zfish   709 DTVSGLSDKKFQHPTEQYPPLRFGTVPNGSTEENIR----SNYPNMHQYM--------VRNNQRG 761

  Fly   708 V----ERVAKGKGSYAFLMESTSIEYVTERN--CELTQVGG--MLDTKSYGIATPPNSPYRTAIN 764
            |    |.:..||.. ||:.::..:.|:..::  |::..:|.  :..|..||:|...||.::..::
Zfish   762 VEDAIENLKTGKLD-AFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGVALHKNSRWKRPLD 825

  Fly   765 SVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVI 829
            ..:|:|..:.::.:|:..|.     .|.|  ...|....:::|.:.|:.|||.:|:..||::.::
Zfish   826 LALLQLVGDDEIDMLERLWL-----SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 883

  Fly   830 AVCEFV--WKSR 839
            ...|.:  ||.|
Zfish   884 FAWEHLVYWKLR 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	66/370 (18%)
		ANF_receptor	42..378	CDD:279440	61/338 (18%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	108/410 (26%)
		Lig_chan	547..823	CDD:278489	70/291 (24%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	66/367 (18%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	111/432 (26%)
		HisJ	<507..>590	CDD:223904	33/84 (39%)
		Lig_chan	605..877	CDD:278489	70/291 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810