DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and grid2

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	901	Identity:	266/901 - (29%)
Similarity:	423/901 - (46%)	Gaps:	149/901 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LPD-IIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLL 89
            ||| ||.||.:|..:....:..||.||..:|.:..||...|:...:|.:...:.|.|.:..|.|:
Zfish    22 LPDSIIHIGAIFDESAKKDDEVFRMAVADLNLNNEILETEKITVSVEFVDGNNPFQAVQEACELM 86

  Fly    90 NIGVAAIFGPQSSHTASHVQSICDNMEIPHL-ENRWDYRLRRESCLVNLYPHPNT---------- 143
            |.|:.|:.......:|..:||:.|.|.|||| ..|......|.||.......|:.
Zfish    87 NRGILALVSSIGCMSAGSLQSLADAMHIPHLFIQRAPAGTPRSSCPPTTRAQPDDYTLFVRPPVY 151

  Fly   144 LSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSD------SGDYRPLL 202
            |:.....:|..:.|:.|.|.|:.:..|..::..|.........::::::..      :|.:|.:.
Zfish   152 LNDVIFQVVMEYTWQKFIIFYDTDYDIRGIENFLDQTSQQGMDVSLQKVESNINMMITGMFRTMR 216

  Fly   203 KQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFR 267
            .:     |.|        |..:.|::|......:...:::...::             ||:..|.
Zfish   217 VE-----ELH--------RYRDTLRRAVLFMSPATAKAFITEVVE-------------TNLVAFD 255

  Fly   268 ----LINEKIVSDVVRQWSIDEKGLLRSANLTTVRS-------------------ETAL------ 303
                :|||:| ||:    .:.|..:.....||.||.                   .|:|
Zfish   256 CQWIIINEEI-SDM----DVQELVMKSIGRLTLVRQTFPLPQNTSQRCVRNNHRINTSLCDPKDP 315

  Fly   304 -----------MYDAVHLFAKALH-DLDTSQQIDIHPISC--DGQSTWQHGFSLINYMKIVEMKG 354
                       :||.|.|.|...| .|:..:...:..:||  .|...||.|.|::..:|...:.|
Zfish   316 KAQMLEITNRYIYDTVLLLANTFHRKLEDRKWHSMASLSCIRKGSKPWQGGKSMLETVKKGGVSG 380

  Fly   355 LTNVIKFDHQGFRTDFMLDIV-----ELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLK 414
            ||::::|:..|...:...:|:     |....|:.::.||:..  .|:|.|.|    .:::|.|::
Zfish   381 LTSLLEFNDNGSNPNIHFEILGTNYGEDRGRGVSRLATWDPI--HGLNGTLT----DRKLENNMR 439

  Fly   415 NKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKL 479
            ...|.|.|:|..|:.|..|:.  |....:::|:::|::..::..|||.|:|.:.||..||| .:.
Zfish   440 GVVLRVVTVLEEPFVMVSENV--LGKPKKYQGFSIDVLDALANYLGFKYEIYVAPDHKYGS-QQA 501

  Fly   480 TGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPL 544
            .|.|||:|.||:.:|||:.::.||||.|||..|||||.:|:..|.:|.|| .::..::|:.|:|.
Zfish   502 DGTWNGLIGELVFKRADVGLSALTITPERESVVDFTTRYMDYSVGVLLRK-AERTVDMFACLAPF 565

  Fly   545 SLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDF 609
            .|.:|..:|...|.|..|:::|....|...|..:       .|..||.|.|||..||.:|||.:.
Zfish   566 DLSLWACIAGTVLLVGTLVYLLNWLNPPRLPMGS-------VSSTTLYNSMWFVYGSFVQQGGEV 623

  Fly   610 LPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGAL------ 668
            ....|:|||:.|:||.|.||:|||||||||||||:.|:::.|:|.:||||||.:.||.:
Zfish   624 PYTTLATRMMMGVWWLFALIVISSYTANLAAFLTISRIENSIQSLQDLAKQTDLPYGTVLDSAVY 688

  Fly   669 -----KGGSTAAFFRDSKISTYQRMWSFME---SARPSVFTASNGEGVERVAKGKGSYAFLMEST 725
                 ||.:  .|.||   ..|.:||..:.   .|..:|  ..:.||:.:|..|:  :||:.::.
Zfish   689 DQVRSKGMN--PFERD---PMYSQMWRMINRTGGAENNV--EESKEGIRKVKYGR--FAFVWDAA 744

  Fly   726 SIEYV--TERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKR 788
            .:|||  .:.:|.|..|...:..:.||:|....||||...:..||:||:.|.:.|||.|||..
Zfish   745 VLEYVAINDEDCSLYTVSNNVADRGYGMAMQHGSPYRDIFSQRILELQQNGDMDILKLKWWPR-- 807

  Fly   789 GGGKC----RVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRK 840
             ...|    .|.|.||.||   |.:.:..|||.||..|:.::|:||..|..|..||
Zfish   808 -DSPCDLYSPVGTRKSGSA---LDIHSFAGVFFVLAAGVVLSCLIATVETWWTRRK 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	90/430 (21%)
		ANF_receptor	42..378	CDD:279440	83/400 (21%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	144/385 (37%)
		Lig_chan	547..823	CDD:278489	107/295 (36%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	90/431 (21%)
		ANF_receptor	42..404	CDD:279440	82/392 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	144/385 (37%)
		Lig_chan	568..841	CDD:278489	107/294 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810