DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KaiR1D and CG11155

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	847	Identity:	372/847 - (43%)
Similarity:	526/847 - (62%)	Gaps:	41/847 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQ---ELAFRQAVDRINADRSILPRSKLVA 68
            ::|.:|::        :.:||.:|::|.:| ..|:.:   |.||:.|:.|||.::::||.::||.
  Fly    28 IILSILVI--------SNALPPVIRVGAIF-TEDERESSIESAFKYAIYRINKEKTLLPNTQLVY 83

  Fly    69 QIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESC 133
            .||.:...|||...|:||..|..||.|||||..:..||||||||:..:|||:|.|.|.....:..
  Fly    84 DIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEF 148

  Fly   134 LVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLS-DSGD 197
            .:||||....|:.||.||:.:..|....||||.:.|   |..|:.:...|...:.:||.| ||
  Fly   149 SINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYG---LFNLMHSSTETKAEMYIRQASPDS-- 208

  Fly   198 YRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTN 262
            ||.:|:.|:......|::|.:...|....:...|:.|....:.|:.|:.||.|.:|::|||...|
  Fly   209 YRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVN 273

  Fly   263 ITGFRL--INEKIVSDVVRQW-SIDEKGLLRSANLTTVRSETALMYDAVHLFAKALH--DLDTSQ 322
            ||.|||  ::.|...:|:.|. .:...||........:::|:|||:|:|:.||..||  :||..|
  Fly   274 ITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDNHQ 338

  Fly   323 QIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGT 387
            ...|..:||....||..|.||.|.:......|||..::| .:|.|..|.|||::|....|:|:|.
  Fly   339 NFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF-VEGRRNIFKLDILKLKQEKIQKVGY 402

  Fly   388 WNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLI 452
            |:.  .||:|    .|......::|:.|.||||.|....||.|.||.. .|:||.:|||:.:||:
  Fly   403 WHP--DDGVN----ISDPTAFYDSNIANITLVVMTREERPYVMVKEDK-NLTGNLRFEGFCIDLL 460

  Fly   453 HEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTP 517
            ..|:..:||.|||:||||..||.....|..|||:::||:|:|||||:|.:||.:.||..:|||.|
  Fly   461 KAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKP 525

  Fly   518 FMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEW----PAYT 578
            |||||:.||::.|..||..||||::||::::|:|:..||:.||..||::|:|:||||    |.|.
  Fly   526 FMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYK 590

  Fly   579 DAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLT 643
            :.  :.||:||::.|..||..|:.::||....|||.|||:|.|.|:||.||:|||||||||||||
  Fly   591 ET--DIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLT 653

  Fly   644 VERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGV 708
            ||||.||||||.|||:||.|.||.|:||||..|||||||..||:||.:||:.:.:||..:..:|:
  Fly   654 VERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGI 718

  Fly   709 ERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEE 773
            :||.  :||||||||||.::|..:|:|.|||:||:||:|.||||||..||:|..|:..||:|||:
  Fly   719 KRVM--EGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEK 781

  Fly   774 GKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKS 838
            |.:.||..||||..  |..|..:.....|.||.||:.|:|||||||:.|:.:|.|:|:.||.|.|
  Fly   782 GIIQILYDKWWKNT--GDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNS 844

  Fly   839 RK 840
            ||
  Fly   845 RK 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	135/374 (36%)
		ANF_receptor	42..378	CDD:279440	125/344 (36%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	202/373 (54%)
		Lig_chan	547..823	CDD:278489	151/279 (54%)
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	135/374 (36%)
		ANF_receptor	61..393	CDD:279440	124/337 (37%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	202/373 (54%)
		Lig_chan	555..829	CDD:278489	151/279 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I765
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.870