DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KaiR1D and gria1b

DIOPT Version :9

Sequence 1:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	890	Identity:	353/890 - (39%)
Similarity:	514/890 - (57%)	Gaps:	87/890 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISP 75
            :|||..:|......|.|..|.||||| |.|.|:...||.|:.:.|.    :|  |||.|::.:..
Zfish     6 VLLLTGLLGLCSCSSFPSNINIGGLF-PTDSHEYDVFRFALSQHND----VP--KLVPQVDMVDT 63

  Fly    76 FDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL--------ENRWDYRLRRES 132
            ..||......|...:.||.||.|.....|.:.:.|.|..:.:..:        .|::..:||.|
Zfish    64 GSSFAMTYAFCSQFSKGVYAIIGLYDRKTMNMLMSFCGALHVCFVTPSFPIDTNNQFVIQLRPE- 127

  Fly   133 CLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPIT---VRQLSD 194
                       |..|.:.:|.|:.|..|..:|.::.|:..||::|.......:.:|   ...|::
Zfish   128 -----------LQDALIALVEHYKWNKFVYMYSSDSGLTVLQKILDTAAEKTWQVTSINFDTLTE 181

  Fly   195 SGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQ-AQQIGMMSDYHSYLVTSLDLHTVNLDEFRY 258
            :. :...::.:.|..|..|:|||..||::.:|.. |.|...:.:|| |::.:|....:||.|||.
Zfish   182 AA-FLKAIQDLDNKKEFKIILDCELERLNSILNLIAAQKKNLKNYH-YILANLGFLDLNLTEFRK 244

  Fly   259 GGTNITGFRLIN--EKIVSDVVRQW-SIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDT 320
            ||.|:|||:|:|  ...||..::.| ..|.|.|  .:....::...||.||.|.:.|.|..:| .
Zfish   245 GGANVTGFQLMNYTNPTVSRTIQDWLEFDSKDL--KSPKRRLKYTGALTYDGVTVMATAFQNL-R 306

  Fly   321 SQQIDIHPISCDGQ------STWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTP 379
            .|:|||......|:      :.|..|..:...::.|:.:|||..::|:.:|.||:|.:.::|..|
Zfish   307 KQRIDISRRGNAGECLANPPAPWGQGIDIQRALQQVQFEGLTGHVQFNDKGHRTNFTVSVMEFGP 371

  Fly   380 AGIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQF 444
            :|.:|:|.||..  :....|.|:|....| ...|:|:|.||||||..||.|.|::...|.|||::
Zfish   372 SGPKKVGYWNQR--EKYVSTATYSNMLNE-TFGLQNRTYVVTTILEAPYVMLKKNHEQLVGNDKY 433

  Fly   445 EGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFERE 509
            |||.|:|..||:|.:|::|:::||.||.||:.:..|..||||:.||:..:||:|:|.||||..||
Zfish   434 EGYCVELAAEIAKHVGYSYRLELVGDGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVRE 498

  Fly   510 QAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEW 574
            :.:||:.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||
Zfish   499 EVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW 563

  Fly   575 PA--------------------------YTDAHGEKVESQ------FTLLNCMWFAIGSLMQQGC 607
            .|                          ..:...||.|.|      |.:.|.:||::|:.|||||
Zfish   564 HADDEEETADQQNQNQPPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIFNSLWFSLGAFMQQGC 628

  Fly   608 DFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGS 672
            |..|::||.|:|.|:|||||||:|||||||||||||||||.|||||||||||||.|.||.|.|||
Zfish   629 DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDGGS 693

  Fly   673 TAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CE 736
            |..|||.|||:.:::|||:|:||.|:||..:..|||.||.|.||.||:|:|||..||:.:|. |:
Zfish   694 TKEFFRRSKIAVFEKMWSYMKSAEPTVFVKTTDEGVVRVRKSKGKYAYLLESTMNEYIEQRKPCD 758

  Fly   737 LTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSS 801
            ..:|||.||:|.||:|||..|..|..:|..:|||.|:|.|..||.|||.:|   |:|......|.
Zfish   759 TMKVGGNLDSKGYGVATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSK 820

  Fly   802 SAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKVAVEER 846
            ...:.|.|:||.|||.:|:||:|:|.::|:.||.:|||   :|.|
Zfish   821 DKTSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSR---IESR 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	110/386 (28%)
		ANF_receptor	42..378	CDD:279440	97/356 (27%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	206/402 (51%)
		Lig_chan	547..823	CDD:278489	152/308 (49%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	110/386 (28%)
		ANF_receptor	41..368	CDD:279440	95/349 (27%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	209/410 (51%)
		Lig_chan	536..842	CDD:278489	152/308 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820